Compositions and methods for treating pathological infections
The present invention relates to compositions and methods for treating pathological infections. An embodiment of the present invention is directed to a topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment which includes a pharmaceutically effective amount of an anti-yeast, anti-fungal or antibacterial pharmaceutically active agent; and a pharmaceutically acceptable carrier.
1 . A topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment comprising a pharmaceutically effective amount of a anti-yeast, anti-fungal or antibacterial pharmaceutically active agent selected from the group consisting of ketones, aldehydes and enantiomers, derivatives and combinations thereof and a pharmaceutically acceptable carrier.
2 . The composition of claim 1 , wherein said pharmaceutically active agent is selected from the group consisting of dihydroxyacetone, dihydroxyacetone phosphate, glyceraldehyde, 3-phosphoglyceraldehyde and enantiomers, derivatives and combinations thereof.
3 . The composition of claim 2 , wherein said pharmaceutically active agent is selected from the group consisting of dihydroxyacetone, dihydroxyacetone phosphate and enantiomers, derivatives and combinations thereof.
4 . The composition of claim 2 , wherein said pharmaceutically active agent is selected from the group consisting of glyceraldehyde, 3-phosphoglyceraldehyde and enantiomers, derivatives and combinations thereof.
5 . The composition of claim 2 , wherein said pharmaceutically active agent is present in an amount from about 0.005% to about 50% by weight.
6 . The composition of claim 2 , wherein said pharmaceutically active agent is present from about 0.005 to about 10% by weight.
7 . The composition of claim 2 , wherein said pharmaceutically active agent is present from about 0.005 to about 5% by weight.
8 . The composition of claim 2 , further comprising at least one additional pharmaceutically active agents selected from the group consisting of analgesics, anesthetics, antibiotics, anti-psoriatic agents, biocides, botanicals, fungicides, insecticides, keratolytic agents, nail conditioners, nail growth agents, nutrients, sunscreens, vitamins and combinations thereof.
9 . The composition of claim 2 , further comprising at least one additional pharmaceutical active agent selected from the group consisting of wherein said at least one active agent is selected from the group consisting of miconazole, econazole, ketoconazole, itraconazole, fluconazole, bifoconazole, terconazole, butoconazole, tioconazole, oxiconazole, sulconazole, saperconazole, clotrimazole, butenafine, undecylenic acid, haloprogin, tolnaftate, nystatin, ciclopirox olamine, terbinafine, amorolfine, naftifine, elubiol, griseofulvin, corticosteroids, calcipotriene, anthraline, minoxidil, minoxidil sulfate, retinoids, cysteine, acetyl cysteine, methionine, glutathione, biotin, finasteride and ethocyn, tea tree oil, mupirocin, neomycin sulfate bacitracin, polymyxin B, 1-ofloxacin, chlortetracycline hydrochloride, oxytetracycline hydrochloride, tetrachcycline hydrochoride, clindamycin phsphate, gentamicin sulfate, benzalkonium chloride, benzethonium chloride, hexylresorcinol, methylbenzethonium chloride, phenol, quaternary ammonium compounds, triclocarbon, triclosan, vitamins, amino acids, betamethasone dipropionate, betamethasone valerate, clobetasol propionate, corticosteroids, hydrogen peroxide, sodium hyperchloridehydroxy acids, keto acids, urea, retinoids, glycols, glycol ethers, dimethyl sufoxide, caprolactam, benzocaine, pramoxine, lidocaine, dyclonine, bupivacaine, prilocaine, ropivacaine, and pharmaceutically acceptable salts thereof and combinations thereof.
10 . The composition of claim 1 , further comprising at least one second pharmaceutical active agent selected from the group consisting of terbinafine, fluconazole, micanozole, doconosol and derivatives, enantiomers, pharmaceutically acceptable salts and combinations thereof.
11 . The composition of claim 1 , further comprising fluconazole or pharmaceutically acceptable salt thereof.
12 . The composition of claim 1 , wherein said composition is a formulation selected from the group consisting of lotions, topical creams, mousses, ointments, solutions, liquids, sprayable liquids, emulsions, lacquers, gels, stand-alone single layer films, multiple layer films, bioadhesive films, patches, bandages with an ointment or gel attached thereto, nail polish and combinations thereof.
13 . A product comprising the composition of claim 1 , wherein said product is in a package selected from the group consisting of a hard tube, squeezable flexible tube, non-aerosolized spray, aerosolized spray, containers with integrated pump, dispensers with an integrated brush or foam attached thereto.
14 . A method for the treatment of yeast, bacterial or fungal infections comprising administering a pharmaceutically effective amount of a pharmaceutically active agent selected from the group consisting of a ketones, aldehydes and derivatives, enantiomers and combinations thereof to a patient in need of such treatment.
15 . The method of claim 14 , wherein said pharmaceutically active agent is selected from the group consisting of dihydroxyacetone, dihydroxyacetone phosphate, glyceraldehyde, 3-phosphoglyceraldehyde and enantiomers, derivatives and combinations thereof.
16 . The method of claim 15 , wherein said pharmaceutically active agent is administered topically to infected skin, nail or mucous membranes.
17 . The method of claim 15 , wherein said pharmaceutically active agent is present in an amount from about 0.005% to about 15%.
18 . The method of claim 14 , further comprising concurrently administering at least one pharmaceutically active agent selected from the group consisting of terbinafine, fluconazole, micanozole, doconosol and a derivatives, enantiomers, pharmaceutically acceptable salts and combinations thereof.
19 . The method of claim 14 , wherein said composition is administered via a brush, spray, felt pad, foam pad, dauber applicator, rubber pad, sponge pad, roll on applicator, stick applicator, pen applicator and combinations thereof.
20 . A composition comprising at least one first pharmaceutically effective amount of a pharmaceutically active agent selected from the group consisting of dihydroxyacetone, dihydroxyacetone phosphate, glyceraldehyde, 3-phosphoglyceraldehyde and enantiomers, derivatives and combinations thereof and at least one second pharmaceutically active agent in a pharmaceutically effective amount selected from the group consisting of terbinafine, fluconazole, micanozole, doconosol and a derivative, enantiomer, pharmaceutically acceptable salt and combination thereof; and a pharmaceutically acceptable carrier.