Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives
View Patent ↗This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R 1 is a radical of the formula —O—SO 2 —R 3 in which R 3 is optionally substituted C 1-6 -alkyl, optionally substituted C 3-8 -cycloalkyl, or optionally substituted phenyl; R 2 is H, optionally substituted C 1-6 -alkyl-CO— or optionally substituted C 1-6 -alkyl-SO 2 —; as well as salts, stereoisomers, tautomers, and hydrates thereof.
1. A method for inhibiting platelet aggregation in a subject in need thereof, comprising administering an effective amount of a compound of general-formula (I):
wherein
R 1 is a radical of the formula —O—SO 2 —R 3 , and
R 3 is a radical selected from the group consisting of optionally substituted C 1-6 -alkyl, optionally substituted C 3-8 -cycloalkyl, and optionally substituted phenyl;
and R 2 is H, optionally substituted C 1-6 -alkyl-CO or optionally substituted C 1-6 -alkyl-SO 2 —;
or a salt, stereoisomer, tautomer, or hydrate thereof.
2. A method of increasing coronary blood flow in a subject in need thereof, comprising administering an effective amount of a compound of general-formula (I):
wherein
R 1 is a radical of the formula —O—S 2 —R 3 , and
R 3 is a radical selected from the group consisting of optionally substituted C 1-6 -alkyl, optionally substituted C 3-8 -cycloalkyl, and optionally substituted phenyl;
and R 2 is H, optionally substituted C 1-6 -alkyl-CO or optionally substituted C 1-6 -alkyl-SO 2 —;
or a salt, stereoisomer, tautomer, or hydrate thereof.