Carbohydrate conjugates to prevent abuse of controlled substances
View Patent ↗The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.
1. An oral pharmaceutical composition comprising:
hydrocodone; and
a disaccharide covalently bound to the hydrocodone via an ester or carbonate bond through a hydroxyl group of the disaccharide and an oxygen atom in the hydrocodone in a manner that renders the hydrocodone pharmacologically inactive or substantially diminishes its activity until unbound hydrocodone is released.
2. An oral pharmaceutical composition comprising a disaccharide covalently bound to hydrocodone via an ester or carbonate group through a hydroxyl group of the disaccharide and an oxygen atom in the hydrocodone in a manner that renders the hydrocodone pharmacologically inactive or substantially diminishes its activity until the unbound hydrocodone is released, wherein the hydrocodone covalently bound to the carbohydrate has the formula:
3. A compound of the formula: