IP Library Granted Patent US 7,119,198
Granted Patent B2
US 7,119,198 · App. 11/182,032 · Granted Oct 10, 2006

Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them

Assignees: Dr. Reddy's Research Foundation; Reddy-Cheminor, Inc.
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Quick Facts
Patent No.
US 7,119,198
App. No.
11/182,032
Granted
Oct 10, 2006
Kind
B2
Abstract

Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

Claims (2)

1. A compound of formula (IIIe)

its tautomeric forms, its stereoisomers, or, its pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , and R 4 are the same or different and represent hydrogen, halogen, hydroxy, cyano, nitro, formyl, or optionally substituted groups selected from alkyl, cyclo(C 3 –C 6 )alkyl alkoxy, cycloalkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl; heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aralkylamino, aminoalkyl, alkoxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, alkylamino, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthio, thioalkyl, aralkoxycarbonylamino, alkoxycarbonyl-amino, aryloxycarbonylamino, COOH, CONH 2 , CONHMe, CONMe 2 , CONHEt, CONHPh, SO 2 OH, SO 2 NH 2 , SO 2 NHMe, SO 2 NMe 2 , or SO 2 NHCF 3 ; wherein when R 1 , R 2 , R 3 or R 4 is substituted, the substituent is selected from halogen, hydroxy, nitro, alkyl, cyclo(C 3 –C 6 )alkyl, alkoxy, cycloalkoxy, aryl, aralkyl, aralkoxyalkyl, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl; heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl; heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aminoalkyl, aryloxy, alkoxycarbonyl, alkylamino, alkoxyalky, alkylthio, thioalkyl groups, COOH, CONH 2 , CONHMe, CONMe 2 , CONHEt, or CONHPh, or SO 2 OH, or SO 2 NH 2 , SO 2 NHMe, SO 2 NMe 2 , or SO 2 NHCF 3 ; A is an optionally substituted benzene ring wherein when A is substituted, the substituent is selected from halogen, hydroxy, nitro, alkyl, cyclo(C 3 –C 6 )alkyl, alkoxy, cycloalkoxy, aryl, aralkyl, aralkoxyalkyl, heterocyclyl selected from the group consisting of aziridinyl, pyrrolidinyl, morpholinyl, piperidinyl and piperazinyl; heteroaryl selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, tetrazolyl, benzopyranyl and benzofuranyl; heteroaralkyl, acyl, acyloxy, hydroxyalkyl, amino, acylamino, arylamino, aminoalkyl, aryloxy, alkoxycarbonyl, alkylamino, alkoxyalky, alkylthio, thioalkyl groups, COOH, CONH 2 , CONHMe, CONMe 2 , CONHEt, CONHPh, SO 2 OH, SO 2 NH 2 , SO 2 NHMe, SO 2 NMe 2 , or SO 2 NHCF 3 ; X represents oxygen, n is an integer of 1 or 2 and L 1 is methane sulphonate, or trifluoromethane sulphonate.

Priority Claims (1)
IN 2416/MAS/97 · Oct 27, 1997 · national
Continuity (4)
Continuation 1000710900 · Nov 19, 2001
Division 0944826000 · Nov 23, 1999
Division 0901258500 · Jan 23, 1998
Related Publication 20060148793A1 · Jul 6, 2006