Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
View Patent ↗The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or can target specific organs.
1. A compound of the formula (V):
wherein L is individually H, (C 1 -C 6 ) alkyl, or a hydroxyl protecting group, n is 2-6 and L″ is (C 2 -C 12 ) alkyl, or is the residue of an alkylene polyol or a polyoxyalkylene glycol.
2. The compound of claim 1 wherein L″ is an alkyl residue of a 1,ω-alkylene diol.
3. The compound of claim 1 wherein L″ is —(CH 2 ) 3 — and n is 2.
4. The compound of claim 1 wherein L is [(C 2 -C 7 )acyl] a hydroxyl protecting group.
5. The compound of claim 4 , wherein the hydroxyl protecting group is acetyl.
6. The compound of claim 4 , wherein the hydroxyl protecting group is (C 2 -C 7 )acyl.
7. The compound of claim 1 wherein L is H, n is 3 and L″ is propyl.
8. The compound 1,2,3-tris(4-hydroxy-butyroyloxy)propane.
9. A pharmaceutical composition comprising 1,2,3,tris(4-hydroxy-butyroyloxy)propane and a pharmaceutically acceptable earner.