Closed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease
View Patent ↗A neurological control system for modulating activity of any component or structure of some or all of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” This system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state or autonomic state and prevent neurological or metabolic signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals, with sensors configured to sense a particular characteristic indicative of a neurological, psychiatric, or metabolic condition.
1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
A. a signal conditioning circuit;
B. a sensor array in communication with said signal conditioning circuit;
C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation;
D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state;
E. an output stage circuit in communication with said control circuit; and
F. a stimulating electrode array, in communication with said output stage circuit, said stimulating electrode array configured to be in communication with a component of the sympathetic nervous system.
2. A system as recited in claim 1 , wherein neural state comprises autonomic index.
3. A system as recited in claim 1 , wherein neural state is controlled to remain within a normal range.
4. A system as recited in claim 1 , wherein autonomic index is controlled to remain within a normal range.
5. A system as recited in claim 1 , wherein neural state is controlled to remain within a control range.
6. A system as recited in claim 1 , wherein autonomic index is controlled to remain within a control range.
7. A system as recited in claim 1 , wherein neural state is controlled to remain outside of a critical range.
8. A system as recited in claim 1 , wherein autonomic index is controlled to remain outside of a critical range.
9. A system as recited in claim 1 , wherein neural state is controlled to prevent the occurrence of at least one of neurological signs and neurological symptoms.
10. A system as recited in claim 1 , wherein autonomic index is controlled to prevent the occurrence of at least one of neurological signs and neurological symptoms.
11. A system as recited in claim 1 , wherein neural state is controlled to prevent the occurrence of metabolic abnormalities.
12. A system as recited in claim 1 , wherein autonomic index is controlled to prevent the occurrence of metabolic abnormalities.
13. A system for neural modulation in the treatment of obesity, comprising:
A. a sensor array in communication with said signal conditioning circuit;
B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state;
C. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state;
D. an output stage circuit in communication with said control circuit; and
E. a neuromodulator array, in communication with said output stage circuit, said neuromodulator array is configured to be in communication with a component of a sympathetic nervous system.
14. A system as recited in claim 13 , wherein neural state comprises autonomic index.
15. A system as recited in claim 13 , wherein neural state is controlled to remain within a normal range.
16. A system as recited in claim 13 , wherein neural state is controlled to remain within a control range.
17. A system for neural modulation in the treatment of metabolic disease, comprising:
A. a sensor array in communication with said signal conditioning circuit;
B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state;
C. a control circuit in communication with said signal processor and which uses a control law to calculate an output which is a function of the neural state;
D. an output stage circuit in communication with said control circuit; and
E. a neuromodulator array, in communication with said output stage circuit, said neuromodulator array is configured to be in communication with a component of a sympathetic nervous system.
18. A system as recited in claim 17 , wherein neural state comprises autonomic index.
19. A system as recited in claim 17 , wherein neural state is controlled to remain within a normal range.
20. A system as recited in claim 17 , wherein neural state is controlled to remain within a control range.
21. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
A. a signal conditioning circuit;
B. a sensor array in communication with said signal conditioning circuit, said sensor array is configured to be in communication with a component of the sympathetic nervous system;
C. a signal processor in communication with said signal conditioning circuit, wherein said signal processor performs neural state estimation;
D. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state;
E. an output stage circuit in communication with said control circuit; and
F. a stimulating electrode array, in communication with said output stage circuit.
22. A system for neural modulation in the treatment of obesity, comprising:
A. a sensor array in communication with said signal conditioning circuit, said sensor array configured to be in communication with a component of a sympathetic nervous system;
B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state;
C. a control circuit in communication with said signal processor and which calculates an output which is a function of the neural state;
D. an output stage circuit in communication with said control circuit; and
E. a neuromodulator array, in communication with said output stage circuit.
23. A system for neural modulation in the treatment of metabolic disease, comprising:
A. a sensor array in communication with said signal conditioning circuit, said sensor array configured to be in communication with a component of a sympathetic nervous system;
B. a signal processor in communication with said sensor array, whereby said signal processor calculates at least one state;
C. a control circuit in communication with said signal processor and which uses a control law to calculate an output which is a function of the neural state;
D. an output stage circuit in communication with said control circuit; and
E. a neuromodulator array, in communication with said output stage circuit.
24. The system for neural modulation as in claim 1 , 13 , 17 , 21 , 22 , or 23 , wherein said signal processor generates a signal which is a function of activity of a component of the sympathetic nervous system.
25. The system for neural modulation as in claim 1 , 13 , 17 , 21 , 22 , or 23 , wherein said control circuit generates a signal which modulates the activity of a component of the sympathetic nervous system.
26. The system for neural modulation as in claim 1 , 13 , 17 , 21 , 22 , or 23 , wherein said output stage circuit generates a signal which modulates the activity of a component of the sympathetic nervous system.
27. The system for neural modulation as in claim 1 , 13 , 17 , 21 , 22 , or 23 , wherein said neuromodulator array is configured to deliver a signal which modulates the activity of a component of the sympathetic nervous system.