Composite self-cohered web materials
The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
1 . An implantable article comprising melt-formed continuous filaments intermingled to form a porous web wherein said filaments are self-cohered to each other at multiple contact points, wherein said filaments comprise at least one semi-crystalline polymeric component covalently bonded to or blended with at least one amorphous polymeric component, wherein the filaments possess partial to full polymeric component phase immiscibility when in a crystalline state, and a hydrogel material placed on at least one of said filaments.
2 . The implantable article of claim 1 wherein the hydrogel is cross-linked.
3 . The implantable article of claim 1 wherein said hydrogel material fills at least part of at least one void space present between said filaments.
4 . The implantable article of claim 3 wherein the hydrogel is cross-linked
5 . The implantable article of claim 1 wherein said implantable article has a percent porosity greater than ninety in the absence of additional components.
6 . The implantable article of claim 1 wherein said implantable article has a percent porosity greater than ninety in the absence of additional components.
7 . The implantable article of claim 1 wherein said hydrogel material comprises polyvinyl alcohol.
8 . The implantable article of claim 1 wherein said hydrogel material comprises carboxymethylcellulose.
9 . The implantable article of claim 1 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
10 . The implantable article of claim 2 wherein said hydrogel material comprises polyvinyl alcohol.
11 . The implantable article of claim 2 wherein said hydrogel material comprises carboxymethylcellulose.
12 . The implantable article of claim 2 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
13 . The implantable article of claim 3 wherein said hydrogel material comprises polyvinyl alcohol.
14 . The implantable article of claim 3 wherein said hydrogel material comprises carboxymethylcellulose.
15 . The implantable article of claim 3 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
16 . The implantable article of claim 1 further comprising a bioactive species in combination with the hydrogel material.
17 . The implantable article of claim 16 wherein the bioactive species comprises an anti-inflammatory.
18 . The implantable article of claim 17 wherein the anti-inflammatory is dexamethasone.
19 . The implantable article of claim 2 further comprising a bioactive species in combination with the cross-linked hydrogel material.
20 . The implantable article of claim 19 wherein the bioactive species comprises an anti-inflammatory.
21 . The implantable article of claim 20 wherein the anti-inflammatory is dexamethasone.
22 . The implantable article of claim 3 further comprising a bioactive species in combination with the hydrogel material.
23 . The implantable article of claim 22 wherein the bioactive species comprises an anti-inflammatory.
24 . The implantable article of claim 23 wherein the anti-inflammatory is dexamethasone.
25 . The implantable article of claim 4 wherein said hydrogel material comprises polyvinyl alcohol.
26 . The implantable article of claim 4 wherein said hydrogel material comprises carboxymethylcellulose.
27 . The implantable article of claim 4 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
28 . The implantable article of claim 4 further comprising a bioactive species in combination with the cross-linked hydrogel material.
29 . The implantable article of claim 28 wherein the bioactive species comprises an anti-inflammatory.
30 . The implantable article of claim 29 wherein the anti-inflammatory is dexamethasone.
31 . An implantable article comprising melt-formed continuous filaments intermingled to form a porous web wherein said filaments are self-cohered to each other at multiple contact points, wherein said filaments comprise a first semi-crystalline polymeric component covalently bonded to or blended with at least one additional semi-crystalline polymeric component, wherein the filaments possess partial to full polymeric component phase immiscibility when in a crystalline state, and a hydrogel material placed on at least one of said filaments.
32 . The implantable article of claim 31 wherein the hydrogel material is cross-linked.
33 . The implantable article of claim 31 wherein said hydrogel material fills at-least part of at least one void space present between said filaments.
34 . The implantable article of claim 33 wherein the hydrogel material is cross-linked.
35 . The implantable article of claim 31 wherein said implantable article has a percent porosity greater than ninety in the absence of additional components.
36 . The implantable article of claim 31 wherein the percent porosity is greater than ninety-one in the absence of additional components.
37 . The implantable article of claim 31 wherein said hydrogel material comprises polyvinyl alcohol.
38 . The implantable article of claim 31 wherein said hydrogel material comprises carboxymethylcellulose.
39 . The implantable article of claim 31 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
40 . The implantable article of claim 32 wherein said hydrogel material comprises polyvinyl alcohol.
41 . The implantable article of claim 32 wherein said hydrogel material comprises carboxymethylcellulose.
42 . The implantable article of claim 32 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
43 . The implantable article of claim 33 wherein said hydrogel material comprises polyvinyl alcohol.
44 . The implantable article of claim 33 wherein said hydrogel material comprises carboxymethylcellulose.
45 . The implantable article of claim 33 wherein said hydrogel material comprises a co-polymer of polyethylene glycol and polypropylene glycol.
46 . The implantable article of claim 31 further comprising a bioactive species in combination with the hydrogel material.
47 . The implantable article of claim 46 wherein the bioactive species comprises an anti-inflammatory.
48 . The implantable article of claim 47 wherein the anti-inflammatory is dexamethasone.
49 . The implantable article of claim 42 further comprising a bioactive species in combination with the cross-linked hydrogel material.
50 . The implantable article of claim 49 wherein the bioactive species comprises an anti-inflammatory.
51 . The implantable article of claim 50 wherein the anti-inflammatory is dexamethasone.