Medical uses of carbamate-substituted pyrazolo-pyridine derivatives
View Patent ↗This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula wherein R 1 is H or a di-C 1-6 -alkylaminocarbonyl radical, and R 2 is a radical of the formula —O—C(X)—NR 3 R 4 wherein X is O or S. The compound may also be administered in combination with at least one organic nitrate or NO donor, or in combination with at least one compound which inhibits the breakdown of cyclic guanosine monophosphate (cGMP).
1. A method for the treatment of sexual dysfunction, comprising administering to a patient an effective amount of a compound of the formula (I)
in which
R 1 is hydrogen or a di-C 1-6 -alkylaminocarbonyl radical,
R 2 is a radical of the formula —O—CX—NR 3 R 4 ,
where
X is O or S;
R 3 and R 4 may be identical or different from one another and each is a radical chosen from H, optionally substituted C 1-6 -alkyl, optionally substituted C 1-6 -alkoxy-C 1-6 -alkyl, optionally substituted hydroxy-C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, optionally substituted C 1-6 -alkylcarbonyloxy-C 1-6 -alkyl, optionally substituted C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, optionally substituted hydroxycarbonyl-C 1-6 -alkyl, phenyl which is optionally substituted by a C 1-6 -alkyl radical, a saturated five- to seven-membered heterocycle which is optionally linked via a C 1-6 -alkyl radical to the nitrogen atom, and optionally substituted C 3-8 -cycloalkyl, where R 3 and R 4 cannot simultaneously be H;
or
R 3 and R 4 together with the nitrogen atom to which they are bonded form a five- to seven-membered saturated heterocycle which may optionally contain a further heteroatom chosen from N, O, and S and/or may optionally be substituted or fused to a phenyl ring;
or a salt, stereoisomer, tautomer, or hydrate thereof.
2. The method according to claim 1 , wherein the compound of the formula (I) is employed in combination with at least one organic nitrate or NO donor or in combination with at least one compound which inhibits the breakdown of cyclic guanosine monophosphate (cGMP).
3. A process for producing medicaments, which comprises converting at least one compound of the formula (I)
in which
R 1 is hydrogen or a di-C 1-64 -alkylaminocarbonyl radical,
R 2 is a radical of formula —O—CX—NR 3 R 4 , where
X is O or S;
R 3 and R 4 may be identical or different from one another and each is a radical chosen from H, optionally substituted C 1-6 -alkyl, optionally substituted C 1-6 -alkoxy-C 1-6 -alkyl, optionally substituted hydroxy-C 1-6 -alkyl, optionally substituted C 2-6 -alkenyl, optionally substituted C 1-6 -alkylcarbonyloxy-C 1-6 -alkyl, optionally substituted C 1-6 -alkoxycarbonyl-C 1-6 -alkyl, optionally substituted hydroxycarbonyl-C 1-6 -alkyl, phenyl which is optionally substituted by a C 1-6 -alkyl radical, a saturated five- to seven-membered heterocycle which is optionally linked via a C 1-6 -alkyl radical to the nitrogen atom, and optionally substituted C 3-8 -cycloalkyl, where R 3 and R 4 cannot simultaneously be H; or
R 3 and R 4 together with the nitrogen atom to which they are bonded form a five- to seven-membered saturated heterocycle which may optionally contain a further heteroatom chosen from N, O, and S and/or may optionally be substituted or fused to a phenyl ring;
or a salt, stereoisomer, tautomer, or hydrate thereof, where appropriate with conventional excipients and additives, into a suitable administration form.