Iontophoresis device
The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
1. An iontophoresis device, comprising an active electrode structure comprising:
an electrode to which a positive electrical potential is applied;
a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and
a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part,
wherein the positively charged drug ions are administered through the cellulose resin film; and wherein the cellulose resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.
2. An iontophoresis device, comprising an active electrode structure comprising:
an electrode to which a positive electrical potential is applied;
a drug holding part for holding a drug solution containing positively chanted drug ions, the drug holding part being placed on the front side of the electrode; and
a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part,
wherein the positively charged drug ions are administered through the cellulose resin film, and wherein:
the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and
the drug holding part is placed on a front side of the anion exchange membrane.
3. An iontophoresis device, comprising an active electrode structure comprising:
an electrode to which a positive electrical potential is applied;
a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and
a cellulose resin film selected from the group consisting of regenerated cellulose, cellulose ester, cellulose ether, and cellulose nitrate and placed on a front side of the drug holding part, wherein the are administered through the cellulose resin film,
a counter electrode structure, comprising:
a second electrode to which a negative electrical potential is applied;
a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;
a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and
a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.
4. An iontophoresis device, comprising an active electrode structure comprising:
an electrode to which a positive electrical potential is applied;
a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; and
a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part,
wherein the drug ions are administered through the cellulose-based resin film.
5. The iontophoresis device according to claim 4 , wherein the cation exchange membrane has a porous structure filled with an ion-exchange resin.
6. The iontophoresis device according to claim 4 , wherein a cation exchange group is introduced to the cellulose-based resin film.
7. The iontophoresis device according to claim 4 , wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.
8. The iontophoresis device according to claim 4 , wherein:
the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and
the drug holding part is placed on a front side of the anion exchange membrane.
9. The iontophoresis device according to claim 4 , further comprising a counter electrode structure, comprising:
a second electrode to which a negative electrical potential is applied;
a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;
a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and
a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.
10. The iontophoresis device according to claim 4 , wherein an interface of the cation exchange membrane and the cellulose-based resin film are bonded, whereby the cation exchange membrane is integrated with the cellulose-based resin film.
11. The iontophoresis device according to claim 10 , wherein the cation exchange membrane has a structure in which a pore of a porous film is filed with an ion-exchange resin.
12. The iontophoresis device according to claim 10 , wherein a cation exchange group is introduced to the cellulose-based resin film.
13. The iontophoresis device according to claim 10 , wherein:
the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on the a front side of the electrolyte solution holding part; and
the drug holding part is placed on a front side of the anion exchange membrane.
14. The iontophoresis device according to claims 10 , further comprising a counter electrode structure, comprising:
a second electrode to which a negative electrical potential is applied;
a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;
a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and
a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.
15. The iontophoresis device according to claim 10 , wherein:
a surface of the cation exchange membrane facing the cellulose-based resin film is roughened; and
the interface are bonded by any one of adhesion with an adhesive, a cross-linking reaction with a cross-linker, and formation of the cellulose-based resin film on the cation exchange membrane.
16. The iontophoresis device according to claim 15 , wherein the cation exchange membrane has a porous structure filled with an ion-exchange resin.
17. The iontophoresis device according to claim 15 , wherein a cation exchange group is introduced to the cellulose-based resin film.
18. The iontophoresis device according to claim 15 , wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.
19. The iontophoresis device according to claim 15 , wherein:
the active electrode structure further comprising an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and
the drug holding part is placed on a front side of the anion exchange membrane.
20. The iontophoresis device according to claim 15 , further comprising a counter electrode structure, comprising:
a second electrode to which a negative electrical potential is applied;
a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;
a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and
a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.
21. The iontophoresis device according to claim 4 , wherein a cation exchange group is introduced to the cellulose-based resin film.
22. The iontophoresis device according to claim 21 , wherein the cellulose-based resin film is filled with an ion-exchange resin with a cation exchange group introduced thereto.
23. The iontophoresis device according to claim 21 , wherein:
the active electrode structure further comprises an electrolyte solution holding part for holding an electrolyte solution in contact with the electrode, and an anion exchange membrane placed on a front side of the electrolyte solution holding part; and
the drug holding part is placed on a front side of the anion exchange membrane.
24. The iontophoresis device according to claim 21 , further comprising: a counter electrode structure comprising:
a second electrode to which a negative electrical potential is applied;
a second electrolyte solution holding part for holding an electrolyte solution in contact with the second electrode;
a second cation exchange membrane placed on a front side of the second electrolyte solution holding part;
a third electrolyte solution holding part for holding an electrolyte solution, the third electrolyte solution holding part being placed on a front side of the second cation exchange membrane; and
a second anion exchange membrane placed on a front side of the third electrolyte solution holding part.