Oral care compositions, devices, and methods of using the same
Oral care compositions, devices and methods are disclosed that employ an amorphous calcium phosphate or a precursor or derivative thereof, and a tooth whitening agent.
1 . An oral care device configured to contact one or more teeth, comprising an amorphous calcium phosphate or a precursor or derivative thereof, and a tooth whitening agent.
2 . The oral care device of claim 1 , wherein the amorphous calcium phosphate comprises a stabilized amorphous calcium phosphate.
3 . The oral care device of claim 2 , wherein the stabilized amorphous calcium phosphate comprises a metal-stabilized or metalloid-stabilized calcium phosphate.
4 . The oral care device of claim 3 , wherein the metal or metalloid is selected from the group consisting of zirconium, silicon, titanium, and mixtures thereof.
5 . The oral care device of claim 2 , wherein the stabilized amorphous calcium phosphate is selected from the group consisting of zirconium-modified amorphous calcium phosphate (Zr-ACP), titanium-modified amorphous calcium phosphate (Ti-ACP), silicon-modified amorphous calcium phosphate (Si-ACP), amorphous calcium phosphate fluoride (ACPF), amorphous calcium carbonate phosphate (ACCP).
6 . The oral care device of claim 2 , wherein the stabilized amorphous calcium phosphate comprises an amino acid, a polypeptide or derivatives of an amino acid or a polypeptide.
7 . The oral care device of claim 6 , wherein the polypeptide comprises a casein phosphopeptide, or a derivative thereof.
8 . The oral care device of claim 2 , wherein the stabilized amorphous calcium phosphate comprises a synthetic polymer.
9 . The oral care device of claim 1 , wherein the tooth whitening agent is selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, carbamides, hypochlorites, chlorine dioxide, and mixtures thereof.
10 . The oral care device of claim 1 , wherein the tooth whitening agent comprises hydrogen peroxide, a complex of thereof, or a source thereof.
11 . The oral care device of claim 1 , wherein the device is in the form of a strip.
12 . The oral care device of claim 11 , wherein the strip comprises a polymeric material.
13 . The oral care device of claim 12 , wherein the polymeric material is selected from the group consisting polyvinylpyrrolidone, a cellulosic polymer, polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, sodium carboxymethyl cellulose, polyethylene oxide, polyethylene glycol, polyacrylic acid, silicone, hydroxypropylmethyl-cellulose phthalate (HPMCP), polyvinyl acetate, cellulose acetate phthalate, gelatin sodium alginate, carbomer, polyvinyl pyrrolidone-vinyl acetate copolymer, polyalkylvinylether-maleic acid copolymer, polypropylene glycol, polyethylene glycol-polypropylene glycol copolymers, quaternized copolymers, quaternized copolymer of vinylpyrrolidone and dimethylaminoethyl methacrylate, and mixtures thereof.
14 . The oral care device of claim 12 , wherein the polymeric material is soluble or swollen by water.
15 . The oral care device of claim 12 , wherein the polymeric has a flexural modulus less than 100,000 psi, as measured using a dynamic mechanical analyzer.
16 . The oral care device of claim 15 , wherein the flexural modulus is less than 25,000 psi.
17 . The oral care device of claim 12 , wherein the polymeric material has a hardness of less than 100 Shore A.
18 . The oral care device of claim 17 , wherein the hardness is less than 50 Shore A.
19 . The oral care device of claim 11 , wherein the strip has more than a single layer.
20 . The oral care device of claim 11 , wherein the strip has two layers.
21 . The oral care device of claim 11 , wherein the strip has three layers.
22 . The oral care device of claim 11 , wherein the strip includes two layers, and wherein each layer is formed of a different polymeric material.
23 . The oral care device of claim 11 , wherein the strip includes:
a first layer configured to contact one or more teeth that comprises the amorphous calcium phosphate;
a third layer; and
a second layer sandwiched between the first and third layers, the second layer comprising the whitening agent.
24 . The oral care device of claim 23 , wherein the first layer comprises polyvinylpyrrolidone, the second layer comprises polyvinylpyrrolidone, and the third layer comprises hydroxypropylmethylcellulose phthalate (HPMCP).
25 . The oral care device of claim 23 , wherein the molecular weight of the HPMCP is greater than 100,000, as measured relative to mono-disperse polyethylene glycol standards in tetrahydrofuran as solvent.
26 . The oral care device of claim 23 , wherein an overall thickness of the strip is from about 0.1 mm to about 2.5 mm.
27 . The oral care device of claim 23 , wherein a thickness of the first layer is from about 0.001 mm to about 0.5 mm.
28 . The oral care device of claim 23 , wherein a thickness of the second layer is from about 0.05 mm to about 1.0 mm.
29 . The oral care device of claim 23 , wherein a thickness of the third layer is from about 0.05 mm to about 0.5 mm.
30 . The oral care device of claim 23 , wherein the layers are formed by casting.
31 . A method of treating teeth, the method comprising:
contacting one or more teeth with a device comprising an amorphous calcium phosphate or a precursor or derivative thereof, and a tooth whitening agent; and
maintaining contact with the one or more teeth for a sufficient time to at least whiten the one or more teeth.
32 . An oral care composition, comprising an amorphous calcium phosphate or a precursor or derivative thereof; and a tooth whitening agent.
33 . The oral care composition of claim 32 , wherein the amorphous calcium phosphate comprises a stabilized calcium phosphate.
34 . The oral care composition of claim 33 , wherein the stabilized amorphous calcium phosphate comprises a metal-stabilized or metalloid-stabilized calcium phosphate.
35 . The oral care composition of claim 34 , wherein the metal or metalloid is selected from the group consisting of zirconium, silicon, titanium, and mixtures thereof.
36 . The oral care composition of claim 33 , wherein the stabilized amorphous calcium phosphate is selected from the group consisting of zirconium-modified amorphous calcium phosphate (Zr-ACP), titanium-modified amorphous calcium phosphate (Ti-ACP), silicon-modified amorphous calcium phosphate (Si-ACP), amorphous calcium phosphate fluoride (ACPF), amorphous calcium carbonate phosphate (ACCP).
37 . The oral care composition of claim 33 , wherein the stabilized amorphous calcium phosphate comprises a polypeptide.
38 . The oral care composition of claim 37 , wherein the polypeptide comprises a casein phosphopeptide, or a derivative thereof.
39 . The oral care composition of claim 33 , wherein the stabilized amorphous calcium phosphate comprises a synthetic polymer.
40 . The oral care composition of claim 32 , wherein the tooth whitening agent is selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, carbamides, hypochlorites, chlorine dioxide, and mixtures thereof.
41 . The oral care composition of claim 32 , wherein the tooth whitening agent comprises hydrogen peroxide, a complex of thereof ,or a source thereof.
42 . The oral care composition of claim 41 , wherein the composition comprises from about 0.1 to about 20% hydrogen peroxide.
43 . The oral care composition of claim 32 , further comprising a polymeric material.
44 . The oral care composition of claim 32 , further comprising a solvent.
45 . The oral care composition of claim 44 , wherein the solvent is a volatile solvent, having a normal atmospheric boiling point of less than 100° C.
46 . The oral care composition of claim 44 , wherein the solvent is selected from the group consisting of ethanol, polyols, glycols, glycerol, propylene glycol, and mixtures thereof.
47 . The oral care composition of claim 44 , wherein the solvent is substantially free of water.
48 . The oral care composition of claim of claim 44 , wherein the solvent includes less than 0.1 percent by weight water.
49 . The composition of claim 32 , further comprising a sweetener, a flavoring or a fragrance.
50 . The oral care composition of claim 32 , wherein the composition is in the form of a liquid.
51 . The oral care composition of claim 32 , wherein the composition is in the form of a gel.
52 . The oral care composition of claim 32 , wherein the composition is in the form of a dentifrice.
53 . The oral care composition of claim 32 , wherein the composition is in the form of a rinse.
54 . The oral care composition of claim 32 , wherein the composition is in the form of a varnish or paint.
55 . A method of treating teeth, the method comprising
applying to a tooth, an oral care composition comprising an amorphous calcium phosphate or a precursor or derivative thereof and a whitening agent; and
allowing the oral care composition to maintain contact with the tooth for sufficient time to at least whiten the tooth.
56 . The method of claim 55 , wherein the sufficient time is less than 5 minutes.
57 . The method of claim 55 , wherein the sufficient time is less than 10 minutes.
58 . The method of claim 55 , wherein the sufficient time is less than 30 minutes.
59 . A method of simultaneously whitening and remineralizing teeth, the method comprising:
contacting one or more teeth with a device that includes an amorphous calcium phosphate or a precursor or derivative thereof, and a tooth whitening agent; and
maintaining contact with the one or more teeth for a sufficient time to at least whiten the one or more teeth.
60 . The method of claim 59 , wherein the method also at least partially remineralizes the one or more teeth.
61 . The method of claim 59 , wherein the method also reduces sensitivity of the one or more teeth.