Triamide-substituted heterobicyclic compounds
View Patent ↗The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R 1 -R 8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
1. A method of reversing, alleviating or inhibiting the progress of obesity in an animal in need of treatment thereof, which comprises administering to the animal a therapeutically effective amount of (S)—N-{2-[benzyl(methyl)amino]-2-oxo-1 -phenylethyl}-1 -methyl-5-[4′-(trifluoromethyl)[1,1′-biphenyl]-2-carboxamido]-1H-indole-2-carboxamide or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 which comprises administering to the animal a therapeutically effective amount of (S)—N-{2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4′-(trifluoromethyl)[1,1′-biphenyl]-2-carboxamido]-1H-indole-2-carboxamide.