Amide substituted imidazopyridines
View Patent ↗Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
1. A method of inducing cytokine biosynthesis in an animal comprising administering a therapeutically effective amount of a compound of the formula (I):
wherein
X is C 1-10 alkylene;
Y is —CO—;
Z is a bond;
R 1 is C 1-10 alkyl;
R 2 is selected from the group consisting of:
C 1-4 alkyl,
ethoxymethyl, and
methoxyethyl;
R 3 and R 4 are methyl; and
R 5 is hydrogen;
or a pharmaceutically acceptable salt thereof to the animal;
wherein the cytokine is IFN-α or TNF-α.
2. The method of claim 1 wherein X is propylene, butylene, or —CH 2 —C(CH 3 ) 2 —.
3. A method of inducing cytokine biosynthesis in an animal comprising administering a therapeutically effective amount of a compound of the formula (I):
wherein
X is C 1-10 alkylene;
Y is —CO—;
Z is a bond;
R 1 is C 1-6 alkyl;
R 2 is selected from the group consisting of:
C 1-4 alkyl,
ethoxymethyl, and
methoxyethyl;
R 3 and R 4 are methyl; and
R 5 is hydrogen, or R 1 and R 5 join to form a ring;
or a pharmaceutically acceptable salt thereof to the animal;
wherein the cytokine is IFN-α or TNF-α.
4. The method of claim 3 wherein R 1 is C 1-4 alkyl.