Closure for container for holding biological samples
A closure for a container, e.g., a tube, for a sample, e.g., a biological sample. The closure comprises a cap having a first opening and a second opening, the first opening capable of communicating with the mouth of a container, the second opening sealed by an exterior seal, and intermediate the first opening and the exterior seal, an interior seal. The invention also provides an assembly comprising the closure of this invention and a container. The invention also provides a method for preparing the closure.
1. A closure for a container having a mouth, said closure comprising (a) a cap, said cap made of a polymeric material, (b) an interior seal having two major surfaces, said interior seal consisting essentially of a layer of brittle material, and (c) an exterior seal having two major surfaces, said exterior seal consisting essentially of an elastomeric material haying a hardness ranging from about 30 Shore A to about 90 Shore A, said layer of brittle material haying two major surfaces, a major surface of said layer of brittle material being in contact with a major surface of said exterior seal.
2. The closure of claim 1 , wherein said cap comprises a substantially cylindrical body having a first opening and a second opening, said first opening capable of communicating with said mouth of said container, said second opening being sealed by said exterior seal, said interior seal being placed between said first opening and said exterior seal.
3. The closure of claim 2 , wherein said first opening and said second opening are circular in shape.
4. The closure of claim 2 , wherein said exterior seal is rupturable by a tip of a pipette and said interior seal is rupturable by a tip of a pipette.
5. The closure of claim 1 , wherein said exterior seal has at least one score line scribed thereon.
6. The closure of claim 1 , wherein said exterior seal has a plurality of score lines scribed thereon.
7. The closure of claim 1 , wherein said exterior seal has at least one slit formed therein, through which at least one slit a tip of a pipette can pass.
8. The closure of claim 1 , wherein said exterior seal has a plurality of slits formed therein, through which slits a tip of a pipette can pass.
9. The closure of claim 1 , wherein said interior seal further comprises a layer of adhesive, said layer of brittle material interposed between said layer of adhesive and said exterior layer.
10. The closure of claim 1 , wherein said polymeric material of said cap comprises a resilient polymeric material.
11. The closure of claim 1 , wherein said polymeric material of said cap comprises polypropylene.
12. The closure of claim 1 , wherein said layer of brittle material is a metallic foil.
13. An assembly comprising a container and the closure of claim 1 .
14. The assembly of claim 13 , wherein said container is made of a polymeric material.
15. The closure of claim 1 , wherein said elastomeric material is selected from the group consisting of natural rubber, styrene-butadiene rubber, polyisoprene, silicone rubber, fluorosilicone rubber, and ethylene propylene rubber.
16. A closure for a container having a mouth, said closure comprising (a) a cap, said cap made of a polymeric material, (b) an interior seal having two major surfaces, said interior seal consisting essentially of a layer of brittle material, a layer of paper, a first layer of adhesive interposed between the layer of brittle material and the layer of paper, and (c) an exterior seal having two major surfaces, said exterior seal consisting essentially of an elastomeric material having a hardness ranging from about 30 Shore A to about 90 Shore A, said layer of paper having two major surfaces, a major surface of said layer of paper being in contact with a major surface of said exterior seal.
17. The closure of claim 16 , wherein said cap comprises a substantially cylindrical body having a first opening and a second opening, said first opening capable of communicating with said mouth of said container, said second opening being sealed by said exterior seal, said interior seal being placed between said first opening and said exterior seal.
18. The closure of claim 17 , wherein said first opening and said second opening are circular in shape.
19. The closure of claim 17 , wherein said exterior seal is rupturable by a tip of a pipette and said interior seal is rupturable by a tip of a pipette.
20. The closure of claim 16 , wherein said exterior seal has at least one score line scribed thereon.
21. The closure of claim 16 , wherein said exterior seal has a plurality of score lines scribed thereon.
22. The closure of claim 16 , wherein said exterior seal has at least one slit formed therein, through which at least one slit a tip of a pipette can pass.
23. The closure of claim 16 , wherein said exterior seal has a plurality of slits formed therein, through which slits a tip of a pipette can pass.
24. The closure of claim 16 , wherein said interior seal further comprises a second layer of adhesive, said layer of brittle material interposed between said second layer of adhesive and said first layer of adhesive.
25. The closure of claim 16 , wherein said polymeric material of said cap comprises a resilient polymeric material.
26. The closure of claim 16 , wherein said polymeric material of said cap comprises polypropylene.
27. The closure of claim 16 , wherein said layer of brittle material is a metallic foil.
28. An assembly comprising a container and the closure of claim 16 .
29. The assembly of claim 28 , wherein said container is made of a polymeric material.
30. The closure of claim 16 , wherein said elastomeric material is selected from the group consisting of natural rubber, styrene-butadiene rubber, polyisoprene, silicone rubber, fluorosilicone rubber, and ethylene propylene rubber.