IP Library › Granted Patent US 7,410,988

Granted Patent B2

US 7,410,988 · App. 11/202,927 · Granted Aug 12, 2008

2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof

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Quick Facts

Patent No.: US 7,410,988
App. No.: 11/202,927
Granted: Aug 12, 2008
Kind: B2

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Abstract

2-Amido-4-substituted-aryl-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

Claims (713)

1. A compound of Formula IV:

and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, and mixtures thereof, wherein

Ar is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl;

Q is selected from cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;

R 1 and R 2 are independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl; or R 1 and R 2 together with the nitrogen to which R 1 and R 2 are attached form a ring chosen from cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, and substituted heteroaryl;

p is selected from 2, 3, 4, and 5; and

q is 0 or 1.

2. The compound of claim 1 wherein p is chosen from 2, 3 and 4 and q is 0.

3. The compound of claim 2 wherein p is chosen from 2 and 3 and q is 0.

4. The compound of claim 1 wherein p is chosen from 2 and 3 and q is 1.

5. The compound of claim 4 wherein p is 2 and q is 1.

6. The compound of claim 1 wherein R 1 and R 2 are independently chosen from C 1-4 alkyl.

7. The compound of claim 1 wherein R 1 and R 2 , together with the nitrogen atom to which R 1 and R 2 are attached form a pyrrolidine, substituted pyrrolidine, piperidine, substituted piperidine, azepane, substituted azepane, piperazine, substituted piperazine, morpholine, or substituted morpholine ring.

8. The compound of claim 7 wherein R 1 and R 2 together with the nitrogen atom to which R 1 and R 2 are attached form a morpholin-4-yl ring.

9. The compound of claim 1 wherein Ar is chosen from substituted aryl, and substituted heteroaryl.

10. The compound of claim 9 wherein Ar is chosen from phenyl, substituted phenyl, benzo[b]thiophen-3-yl, substituted benzo[b]thiophen-3-yl, pyridin-2-yl, substituted pyridin-2-yl, pyridin-3-yl, substituted pyridin-3-yl, pyridin-4-yl, substituted pyridin-4-yl, thiophen-2-yl, substituted thiophen-2-yl, thiophen-3-yl, substituted thiophen-3-yl, 4-isoxazolyl, substituted 4-isoxazolyl, 5-isoxazolyl, substituted 5-isoxazolyl, 3-pyrazolyl, substituted 3-pyrazolyl, 4-pyrazolyl, substituted 4-pyrazolyl, naphthalene-2-yl, substituted napthalen-2-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, substituted 2,3-dihydro-1,4-benzodioxin-6-yl, 3,4-dihydro-2H-1,5-benzodioxepin-7-yl, substituted 3,4-dihydro-2H-1,5-benzodioxepin-7-yl, benzothiazol-2-yl, substituted benzothiazol-2-yl, benzofuran-2-yl, and substituted benzofuran-2-yl.

11. The compound of claim 10 wherein Ar is chosen from phenyl, substituted phenyl, 4-isoxazolyl, substituted 4-isoxazolyl, 5-isoxazolyl, substituted 5-isoxazolyl, 3-pyrazolyl, substituted 3-pyrazolyl, 4-pyrazolyl, substituted 4-pyrazolyl, benzofuran-2-yl, and substituted benzofuran-2-yl.

12. The compound of claim 1 wherein Q is chosen from C 5-10 monocyclic heteroaryl, and substituted monocyclic C 5-10 heteroaryl.

13. The compound of claim 1 wherein Q is chosen from phenyl, substituted phenyl, furanyl, substituted furanyl, cyclohexyl, substituted cyclohexyl, cyclopentenyl, substituted cyclopentenyl, 4-isoxazolyl, substituted 4-isoxazolyl, 5-isoxazolyl, substituted 5-isoxazolyl, thiophene-2-yl, substituted thiophene-2-yl, pyrimidin-2-yl, substituted pyrimidin-2-yl, 5-thiadiazolyl, substituted 5-thiadiazolyl, imidazolyl, substituted imidazolyl, 3-isothiazolyl, substituted thiazolyl, 3-pyrrolyl, and substituted 3-pyrrolyl.

14. The compound of claim 13 wherein Q is chosen from thiophene, and substituted thiophene.

15. A pharmaceutical composition comprising at least one pharmaceutically acceptable vehicle, and a therapeutically effective amount of a compound of claim 1 .

16. The pharmaceutical composition of claim 15 further comprising at least one additional therapeutic agent appropriate for effecting combination therapy.

17. The pharmaceutical composition of claim 16 wherein said at least one additional therapeutic agent appropriate for effecting combination therapy is chosen from estrogen receptor modulators, cytostatic/cytotoxic agents, anti-proliferative agents, cell cycle checkpoint inhibitors, angiogenesis inhibitors, monoclonal antibody targeted therapeutic agents, tyrosine kinase inhibitors, serine-threonine kinase inhibitors, histone deacetylase inhibitors, heat shock protein inhibitors, and famesyl transferase inhibitors.

18. The compound of claim 8 wherein p is 3 and q is 0.

19. The compound of claim 11 wherein Ar is substituted phenyl.

20. The compound of claim 11 wherein Ar is 3-substituted isoxazol-5-yl.

21. The compound of claim 20 wherein Ar is 3-phenyl isoxazol-5-yl.

22. The compound of claim 21 wherein Q is thiophen 2-yl or substituted thiophen-2-yl.

23. The compound of claim 1 selected from:

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)benzamide;

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-phenylthiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)furan-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxanilde;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)furan-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)benzamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)furan-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-phenylthiazol-2-yl)benzamide;

N-(3-(azepan-1-yl)propyl)-N-(4-phenylthiazol-2-yl)thiophene-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-phenylthiazol-2-yl)furan-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)benzamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(4-methoxyphenyl)tbiazol-2-yl)furan-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)benzamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-(azepan-1-yl)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)furan-2-carboxamide;

N-(3-(4-methylpiperazin-1-yl)propyl)-N-(4-phenylthiazol-2-yl)benzamide;

N-(3-(4-methylpiperazin-1-yl)propyl)-N-(4-phenylthiazol-2-yl)thiophene-2-carboxamide;

N-(3-(4-methylpiperazin-1-yl)propyl)-N-(4-phenylthiazol-2-yl)furan-2-carboxamide;

N-(4-(4-methoxyphenyl)tbiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)furan-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)benzamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)furan-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)cyclopent-1-enecarboxamide;

4-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)benzamide;

3-fluoro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methyl-N-(3-morpholinopropyl)benzamide;

2-fluoro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-methyl-N-(3-morpholinopropyl)benzamide;

2-cyano-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-5-methyl-N-(3-morpholinopropyl)furan-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methyl-N-(3-morpholinopropyl)furan-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-chlorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-p-tolylthiazol-2-yl)thiophene-2-carboxamide;

N-(4-(2,3-dihydrobenzo [b][1,4]dioxin-6-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-chloro-3-nitrophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxaniide;

N-(4-(2-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(2,4-dimethylphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-cyanophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

methyl 4-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)benzoate;

N-(4-(4-(methylsulfonyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(2,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-3-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(2-chlorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide, N-(4-(3-chlorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(benzo[b]thiophen-3-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(pyridin-3-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(thiophen-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(5-chlorothiophen-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(5-morpholinopentyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(5-morpholinopentyl)thiophene-2-carboxamide;

N-(4-(3,4-dichlorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-fluorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(difluoromethoxy)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(2-(trifluoromethyl)phenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(2-fluorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3,4-difluorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3-bromophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(3-fluorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3-methylbenzol[b]thiophen-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3-cyanophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-.morpholinopropyl)-N-(4-(4-pentylphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(4-(diethylamino)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-.morpholinopropyl)-N-(4-(4-(pyrrolidin-1-yl)phenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(benzo[d][1,3]dioxol-5-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(benzo[d]thiazol-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(2-nitrophenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyi)-N-(4-(naphthalen-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-morpholinophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(2-chloropyridin-4-yl)thiazol-2-yl)-N-(3-morpholinopropyl)tbiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methyl-N-(3-morpholinopropyl)thiophene-2-carboxamide;

2,5-dichloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-3-carboxamide;

3-bromo-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)-5-nitrothiophene-2-carboxamide;

5-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

5-acetyl-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

5-bromo-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-5-(methylthio)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-methyl-N-(3-morpholinopropyl)-1H-pyrrole-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)isoxazole-5-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-3,5-dimethyl-N-(3-morpholinopropyl)isoxazole-4-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-methyl-N-(3-morpholinopropyl)-1,2,3-thiadiazole-5-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-2,4-dimethyl-N-(3-morpholinopropyl)thiazole-5-carboxamide;

4-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)picolinamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methyl-N-(3-morpholinopropyl)isoxazole-4-carboxamide;

6-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)picolinamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-methyl-N-(3-morpholinopropyl)-1H-imidazole-2-carboxamide;

4,5-dichloro-N-(4-(4-rnethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)isothiazole-3-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-1,2,5-trimethyl-N-(3-morpholinopropyl)-1H-pyrrole-3-carboxamide;

ethyl 2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxylate;

ethyl 3-methyl-3-(2-(N-(3-morpholinopropyl)thiophene-2-carboxaniido)thiazol-4-yl)butanoate;

N-(4-(biphenyl-4-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(5-methyl-1-phenyl-1H-pyrazol-4-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxaniide;

N-(4-(2,4-dichlorophenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

3-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)benzoic acid;

N-(3-morpholinopropyl)-N-(4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(5-(pyridin-2-yl)thiophen-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4′-methyl-2′-(pyrazin-2-yl)-4,5′-bithiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

2-(5-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)thiophen-2-yl)acetic acid;

N-(4-(4-chloro-3-methylphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)benzamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)furan-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)furan-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)nicotinamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)cyclopentanecarboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)cyclobutanecarboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)cyclobutanecarboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)picolinamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)picolinamide;

N-(4-(3-(4-chlorophenyl)isoxazol-5-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)furan-2-carboxamide;

1-methyl-N-(3-morpholinopropyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)-1H-pyrrole-2-carboxamide;

4-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)benzoic acid;

N-(3-morpholinopropyl)-N-(4-(trifluoromethyl)thiazol-2-yl)thiophene-2-carboxaniide;

ethyl 5-(2-(N-(3-morpholinopropyl)thiophene-2-carboxaniido)thiazol-4-yl)isoxazole-3-carboxylate;

2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)-N-(1,3,4-thiadiazol-2-yl)thiazole-4-carboxamide;

2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)-N-(thiazol-2-yl)thiazole-4-carboxamide;

N-(3-methoxyphenyl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

N-(3-methoxybenzyl)-2-(N-(3-morpholinopropyl)tbiophene-2-carboxamido)thiazole-4-carboxamide;

N-(3-chlorobenzyl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)tbiazole-4-carboxaniide;

N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

N-(benzo[d]thiazol-6-yl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

N-(3-carbamoylphenyl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

ethyl 2-(2-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamido)thiazol-4-yl)acetate;

N-(3-(methylsulfonamido)phenyl)-2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazole-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)furan-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-1-methyl-N-(3-(2-oxopyrrolidin-1-yl)propyl)-1H-pyrrole-2-carboxamide;

N-(3-(2-oxopyrrolidin-1-yl)propyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)furan-2-carboxanilde;

N-(3-(2-oxopyrrolidin-1-yl)propyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol)-2-carboxamide;

1-methyl-N-(3-(2-oxopyrrolidin-1-yl)propyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)-1H-pyrrole-2-carboxamide;

N-(3-(4-methylpiperazin-1-yl)propyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)furan-2-carboxamide;

N-(4-morpholinobutyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)furan-2-carboxamide;

N-(4-morpholinobutyl)-N-(4-(3-phenylisoxazol-5-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(3-(diethyIamino)propyl)-N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-.(2-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)tbiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-N-(2-morpholinoethyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(diethylamino)propyl)thiophene-2-carboxamide;

N-(3-(1H-imidazol-1-yl)propyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxanilde;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-morpholinobutyl)thiophene-2-carboxamide;

N-(4-(5-methylthiophen-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(6-methoxypyridin-3-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(2,6-dimethoxypyridin-3-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxarnide;

N-(4-cyclopentylthiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-cyclohexylthiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

methyl 6-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)nicotinate;

N-(4-(1H-indol-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(7-methoxybenzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(5-methoxybenzofuran-2-yl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(3-morpholinopropyl)-N-(4-(5-nitrobenzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(4-(2-hydroxyethylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(2-morpholinoethylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(methylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(3-(dimethylamino)propylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(3-hydroxypropylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-carbamoylphenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(dimethylcarbamoyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

2-(4-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)benzamido)acetic acid;

N-(4-(4-(4-methylpiperazine-1-carbonyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxaniide;

N-(4-(4-(morpholine-4-carbonyl)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxanilde;

2-(3-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)phenoxy)acetic acid;

3-(3-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)phenoxy)propanoic acid;

2-(4-(2-(N-(3-morpholinopropyl)thiophene-2-carboxaniido)thiazol-4-yl)phenoxy)acetic acid;

3-(4-(2-(N-(3-morpholinopropyl)thiophene-2-carboxamido)thiazol-4-yl)phenoxy)propanoic acid;

N-(4-(3-(3-(dimethylamino)propoxy)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(3-(2-(dimethylainino)ethoxy)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(4-(3-(dimethylamino)propoxy)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxaniide;

N-(4-(4-(2-(dimethylamino)ethoxy)phenyl)thiazol-2-yl)-N-(3-morpholinopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-hydroxyethylamino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(hydroxymethyl)pyrrolidin-1-yl)-3-oxopropyl)thiophene-2-carboxaniide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-hydroxypiperidin-1-yl)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-((2-hydroxyethyl)(methyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(bis(2-hydroxyethyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-oxo-3-(piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-((2-(dimethylamino)ethyl)(methyl)amino)-3-oxopropyl)thiophene-2-carboxarnide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(methyl(2-(methylamino)ethyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-hydroxypyrrolidin-1-yl)-3-oxopropyl)thiophene2-carboxaniide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(dimethylamino)pyrrolidin-1-yl)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-((2,3-dihydroxypropyl)(methyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)piperidine-3-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-oxo-3-(thiazolidin-3-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-morpholino-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-((2-cyanoethyl)(methyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(hydroxymethyl)piperidin-1-yl)-3-oxopropyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)piperidine-3-carboxylic acid;

N-(3-(3-acetamidopyrrolidin-1-yl)-3-oxopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)pyrrolidine-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-oxo-3-(3-oxopiperazin-1-yl)propyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)piperidine-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-oxo-3-(2-phenoxyethylamino)propyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)-N-(2-hydroxyethyl)piperidine-3-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(isobutyl(1,1-dioxo-tetrahydrothiophen-3-yl)amino)-3oxopropyl)thiophene-2-carboxamid

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(4-(2-(dimethylaminO)ethyl)piperaZifl-1-yl)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-((2,3-dihydroxypropyl)(methyl)amino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-((5-methylpyrazin-2-yl)methylamiflO)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(1-hydroxypropan-2-ylamino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(piperidin-1-yl)butyl)thiophene-2-carboxamide;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanOyl)piperidifle-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-((2-hydroxyethyl)(pheflyl)anhiflo)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(2-(pyridin-4-yl)ethylamino)butyl)thiophene-2-carboxamide;

tert-butyl 4-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)piperazine-1-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(pyridin-3-ylmethylamino)butyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(5-(methylsulfonyl)indolin-1-yl)-4-oxobutyl)thiophene-2-carboxamide;

tert-butyl 1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)pyrrolidin-3-ylcarbamate;

N-(4-(3-acetamidopyrrolidin-1-yl)-4-oxobutyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

methyl 1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)piperidine-4-carboxylate;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)-N-methylpiperidine-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)-4-oxobutyl)thiophene-2-carboxamide;

ethyl 2-(1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)piperidin-3-yl)acetate;

ethyl 2-(1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)piperidin-4-yl)acetate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(4-(diethylamino)piperidin-1-yl)-4-oxobutyl)thiophene-2-carboxamide;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)pyrrolidine-2-carboxamide;

methyl 1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)pyrrolidine-2-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(3-oxopiperazin-1-yl)butyl)thiophene-2-carboxamide;

N-(4-(2-amino-2-oxoethylamino)-4-oxobutyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)-N-(2-hydroxyethyl)piperidine-3-carboxamide;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanoyl)-N-(2-hydroxyethyl)piperidine-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(2-(methylsulfinyl)ethylamino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-((2-hydroxyethyl)(pyridin-4-ylmethyl)amino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(cyclohexyl(4-hydroxybutyl)amino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-((2-cyanoethyl)((tetrahydrofuran-2-yl)methyl)amino)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(2-(pyridin-3-yl)pyrrOlidin-1-yl)butyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(1-hydroxypropan-2-ylamino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-methoxyethylamino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(furan-3-ylmethylamino)-3-oxopropyl)thiophene-2-carboxaniide;

methyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propanoyl)pyrrolidine-2-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(isoindolin-2-yl)-3-oxopropyl)thiophene-2-carboxamide;

N-(3-((1,4-dioxan-2-yl)methylaniino)-3-oxopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(cyclohexyl(4-hydroxybutyl)amino)-3-oxopropyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(methyl(pyridin-4-yl)amino)-3-oxopropyl)thiophene-2-carboxamide;

1-(4-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)butanOyl)piperidifle-3-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(pyridin-2-ylmethylamino)butyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-oxo-4-(thiazolidin-3-yl)butyl)thiophefle-2-carboxamide;

tert-butyl 2-(4-(N-(4-(benzofuran-2-yl)tbiazol-2-yl)thiophene-2-carboxamido)butanamido)ethylcarbamate;

(S)-N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(2-(hydroxymethyl)indolin-1-yl)-4-oxobutyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(4-(isoindolin-2-yl)-4-oxobutyl)thiophene-2-carboxamide;

N-(3-acetamidopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-Carboxamide;

1-acetyl-N-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(piperidin-1-yl)propanamido)propyl)thiophene-2-carboxaniide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(dimethylamino)butanamido)propyl)thiophene-2-carboxamide;

N-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)isonicotinamide;

N-(3-(4-acetamidobutanamido)propyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanamido)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(2,5-dioxoimidazolidin-4-yl)acetamido)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-morpholinopropananiido)propyl)thiophene-2-carboxamide;

N-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)-1,5-dimethyl-1H-pyrazole-3-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-morpholinoacetamido)propyl)thiophene-2-carboxamide;

(S)-tert-butyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)pyrrolidine-2-carboxylate;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-3-carboxamide;

ethyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-2-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-hydroxypiperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-hydroxyethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-cyanoethyl)piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(hydroxymethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(dimethylamino)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

ethyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-3-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-hydroxypiperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(N-ethylacetamido)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(N-methylacetamido)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

tert-butyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)pyrrolidin-3-ylcarbamate;

(S)-N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(methoxymethyl)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(3-(3-acetamidopyrrolidin-1-yl)propyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

ethyl 4-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperazine-1-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(morpholine-4-carbonyl)piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4,4-dihydroxypiperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(tetrahydrofuran-2-carbonyl)piperazifl-1-yl)propyl)thiophene-2-carboxainide;

(R)-1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)-N-methylpyrrolidine-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)pyrrolidine-2-carboxaniide;

methyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)pyrrolidine-2-carboxylate;

methyl 1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-2-carboxylate;

(S)-1-(3-(N-(4-(benzofuran-2-yl)tbiazol-2-yl)thiophene-2-carboxamido)propyl)-N,N-dimethylpyrrolidine-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-oxopiperazin-1-yl)propyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-2-carboxamide;

ethyl 2-(4-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperazin-1-yl)acetate;

tert-butyl 4-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperazine-1-carboxylate;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-morpholinopiperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(hydroxymethyl)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(2-hydroxyethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-(hydroxymethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(hydroxymethyl)piperidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(3-hydroxypyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

(S)-N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(2-(hydroxymethyl)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(3-(4-acetylpiperazin-1-yl)propyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)-N,N-diethylpiperidine-3-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)thiophene-2-carboxaniide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-methoxyethyl)piperazin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(benzofuran.-2-yl)thiazol-2-yl)-N-(3-(3-(diethylamino)pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)-N-methylpiperidine-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(diethylamino)piperidin-1-yl)propyl)thiophene-2-carboxamide;

(R)-1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)pyrrolidine-2-carboxylic acid;

1-(3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propyl)piperidine-4-carboxamide;

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(2-(dimethylamino)-2-oxoethyl)piperazin-1-yl)propyl)thiophene-2-carboxamide; and

N-(4-(benzofuran-2-yl)thiazol-2-yl)-N-(3-(4-(methylsulfonyl)piperazin-1-yl)propyl)thiophene-2-carboxamide.

24. The compound of claim 1 selected from:

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(dimethylamino)propyl)benzamide;

N-(3-(dimethylamino)propyl)-2-fluoro-N-(4-phenylthiazol-2-yl)benzamide;

N-(3-(diethylamino)propyl)-N-(4-phenylthiazol-2-yl)furan-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(dimethylamino)propyl)-2-fluorobenzaniide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(dimethylamino)propyl)thiophene-2-carboxamide;

N-(3-(diethylamino)propyl)-N-(4-phenylthiazol-2-yl)thiophene-2-carboxamide;

2-chloro-N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)benzamide;

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)furan-2-carboxamide;

N-(3-(diethylamino)propyl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)benzan-iide;

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-2-fluorobenzamide;

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)benzaniide;

N-(3-(diethylamino)propyl)-N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)thiophene-2-carboxamide;

N-(4-phenylthiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;

N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)furan-2-carboxamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-.yl)propyl)benzamide;

N-(4-(2,5-dimethoxyphenyl)thiazol-2-yl)-N-(3-(pyrrolidin-1-yl)propyl)thiophene-2-carboxamide;