Solvent free amorphous rapamycin
View Patent ↗An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents.
1. A method of forming amorphous rapamycin from crystalline rapamycin comprising:
dissolving crystalline rapamycin in 2-propanol to form a solution;
forming an amorphous rapamycin precipitate by adding water to the solution wherein the concentration of rapamycin dissolved in the solution determines a time period within which the precipitate is formed; and
minimizing autoxidation of the amorphous rapamycin by reducing exposure thereof to free radicals, residual solvents and autoxidation initiators by using low hydroperoxide solvents, by reducing dissolved oxygen via inert gas blanketing, by increasing the glass transition temperature of the amorphous rapamycin.