Diketopiperazine salts for drug delivery and related methods
View Patent ↗Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
1. A dry powder therapeutic composition comprising:
a pharmaceutically acceptable anion of a heterocyclic compound according to Formula 1:
wherein R 1 and/or R 2 comprise a terminal carboxlate functional group and E 1 and E 2 are NH such that said anion is selected from the group consisting of 3,6-di(succinate-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(maleate-4-aminobutyl)-2,5-diketopiperazine, 3,6-di(fumarate-4-aminobutyl)-2,5-diketopiperazine and 3,6-di(glutamate-4-aminobutyl)-2,5-diketopiperazine; and
at least one cation; and
a biologically active agent; and wherein said dry powder therapeutic composition is formed by spray drying.
2. The dry powder therapeutic composition of claim 1 wherein said biologically active agent is selected from the group consisting of hormones, anticoagulants, immunomodulating agents, cytotoxic agents, antibiotics, antivirals, antisense, antigens, antibodies and active fragments and analogues thereof.
3. The dry powder therapeutic composition of claim 2 wherein said hormone comprises insulin.
4. The dry powder therapeutic composition of claim 1 , wherein said dry powder is formulated into a solid dosage form suitable for oral, buccal, rectal, or vaginal administration.
5. The dry powder therapeutic composition of claim 4 wherein said solid dosage from is selected from the group consisting of a capsule, a tablet, and a suppository.
6. The dry powder therapeutic composition of claim 1 wherein said dry powder comprises particles having a diameter between about 0.5 microns and about ten microns.
7. The composition of claim 1 wherein the particles of said dry powder are suitable for pulmonary delivery.
8. The composition of claim 1 wherein the particles of said dry powder have a rugosity of less than 2.
9. The dry powder therapeutic composition of claim 1 wherein said cation is selected from the group consisting of sodium, potassium, calcium, lithium, triethylamine, butylamine, diethanolamine and triethanolamine.
10. The dry powder therapeutic composition of claim 1 wherein said selected anion is 3,6-di(fumarate-4-aminobutyl)-2,5-diketopiperazine.
11. The dry powder therapeutic composition of claim 1 wherein said selected anion is 3,6-di(succinate-4-aminobutyI)-2,5-diketopiperazine.
12. The dry powder therapeutic composition of claim 1 wherein said selected anion is 3,6-di(maleate-4-aminobutyl)-2,5-diketopiperazine.
13. The dry powder therapeutic composition of claim 1 wherein said selected anion is 3,6-di(glutamate-4-aminobutyl)-2,5-diketopiperazine.