Method for treating bone cancer pain or chemotherapy induced pain
View Patent ↗The present invention is directed to the use of a class of peptide compounds for treating tumor pain, in particular bone cancer pain, for treating chemotherapy-induced pain and for treating nucleoside-induced pain.
1. A method for alleviating and/or treating bone cancer pain and/or chemotherapy-induced pain in a subject, comprising administering to the subject (R)-2-acetamido-N-benzyl-3-methoxypropionamide or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the chemotherapy-induced pain is chemotherapy-induced neuropathic pain and/or vinca alkaloid-induced pain.
3. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is substantially enantiopure.
4. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered at a dose of 100 mg/day to 6 g/day.
5. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered at a dose of 200 mg/day to 1 g/day.
6. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered at increasing daily doses until a predetermined daily dose is reached which is maintained during further treatment.
7. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered in no more than three doses per day.
8. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered in a pharmaceutical composition resulting in a plasma concentration of 0.1 to 15 μg/ml (trough) and 5 to 18.5 μg/ml (peak), calculated as an average over a plurality of treated subjects.
9. The method of claim 1 , wherein the (R)-2-acetamido-N-benzyl-3-methoxypropionamide or salt thereof is administered orally or intravenously.
10. The method of claim 1 , wherein the subject is a mammal.
11. The method of claim 10 , wherein the subject is human.
12. The method of claim 2 , wherein the vinca alkaloid-induced pain is vincristine-induced pain.