Canine influenza vaccines
View Patent ↗The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.
1. A method of eliciting an immune response in a canine against an equine strain of influenza, comprising administering a composition comprising a recombinant poxvirus that contains DNA encoding and that expresses in vivo in a canine, equine influenza antigen comprising equine influenza H3 and a pharmaceutically or veterinarily acceptable carrier, excipient or vehicle in an effective amount for eliciting the immune response.
2. The method of claim 1 , wherein the composition further comprises an adjuvant.
3. The method of claim 1 , wherein the DNA is isolated from a canine infected with equine influenza.
4. The method of claim 3 wherein the DNA is isolated from a broncho alveolar lavage of the infected canine.
5. The method of claim 3 , wherein the DNA is isolated from lung tissue of the infected canine.
6. The method of claim 1 , wherein the DNA is isolated from an equine influenza virus isolate.
7. The method of claim 6 , wherein the equine influenza virus is selected from the group consisting of an Ohio equine influenza virus isolate, a Kentucky equine influenza virus isolate, a Newmarket equine influenza virus isolate or mixtures thereof.
8. The method of claim 1 , wherein the poxvirus is an avipox virus.
9. The method of claim 8 wherein the avipox virus is a canarypox virus.
10. The method of claim 1 , wherein the canarypox virus is ALVAC.
11. The method of claim 10 , wherein the DNA is from a Kentucky equine influenza virus isolate.
12. The method of claim 10 , wherein the DNA is from a Newmarket equine influenza virus isolate.
13. The method of claim 9 , wherein the canarypox virus is selected from CP1529, CP1533 or CP2242.
14. The method of claim 1 wherein the equine influenza antigen comprises H3N8 codon optimized HA.
15. The method of claim 1 wherein the equine influenza antigen is H3.
16. The method of claim 10 wherein the DNA is from Ohio equine influenza virus isolate.