Minimally compliant, volume-efficient piston for osmotic drug delivery systems
View Patent ↗An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
1. An osmotic delivery system comprising:
a capsule having an interior for holding a beneficial agent;
an osmotic agent located in the interior; and
a movable piston having a length to total diameter ratio of about 1.1:1 and a core diameter to overall diameter ratio of about 0.9:1 located within the interior of the capsule, defining a seal with an interior surface of the capsule that separates the osmotic agent from the beneficial agent.
2. The osmotic delivery system according to claim 1 , wherein the piston includes one or a plurality of ribs for effecting the seal with the interior surface.
3. The osmotic delivery system according to claim 1 , wherein the capsule includes a cylindrical tube.
4. The osmotic delivery system according to claim 3 , wherein the cylindrical tube includes an opening and further includes a semipermeable body within the opening.
5. The osmotic delivery system according to claim 1 , wherein the osmotic agent includes a tablet.
6. An osmotic delivery system comprising:
a piston having a length to overall diameter ratio not greater than about 1.1:1 and a core diameter to overall diameter ratio not greater than about 0.9:1;
an osmotic agent; and
an enclosure having an interior holding the piston and the osmotic agent, the piston being movable with respect to the enclosure.
7. The osmotic delivery system according to claim 6 , wherein the interior of the enclosure includes an interior surface, the piston abutting against the interior surface.
8. The osmotic delivery system according to claim 6 , further comprising a semipermeable body in liquid communication with the osmotic agent and within the enclosure.
9. The osmotic delivery system according to claim 6 , wherein the enclosure is fluid impermeable.
10. The osmotic delivery system according to claim 8 , wherein the osmotic agent is located between the semipermeable body and the piston.
11. The osmotic delivery system according to claim 6 , further comprising a beneficial agent located in the interior of the enclosure, the beneficial agent being delivered from the enclosure when the piston moves.
12. The osmotic delivery system according to claim 6 , wherein the piston is fluid impermeable.
13. The osmotic delivery system according to claim 6 , wherein the piston includes at least one rib for effecting a movable seal with the enclosure.
14. The osmotic delivery system according to claim 6 , further comprising a beneficial agent located in the interior of the enclosure, the piston defining a movable seal that separates the osmotic agent from the beneficial agent.
15. An osmotic delivery system comprising:
a capsule having a tubular interior, the tubular interior having an interior surface;
a semipermeable body located at least partially within the tubular interior;
an osmotic agent located between the semipermeable body and a piston;
a beneficial agent located within the tubular interior; and
a piston located within the tubular interior, the piston having a length to overall diameter ratio less than about 1.1:1 and a core diameter to overall diameter ratio less than about 0.9:1, the piston separating the beneficial agent from the osmotic agent, and being movable with respect to the interior surface of the tubular interior and with respect to the semipermeable body.
16. The osmotic delivery system according to claim 15 , wherein the piston includes at least one rib.