Topical endoparasiticide and ectoparasiticide formulations
A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to use and avoids the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of a macrocyclic lactone, a neo-nicotinoid and optionally, an insect growth regulator. The topical formulation can be packaged together or packaged so that the macrocyclic lactone and the neo-nicotinoid are stored separately prior to administering the topical insecticide formulation to the animal.
1. A topical formulation comprising a first active ingredient comprising approximately 0.2 to 1.75 mg ivermectin per ml of total volume of formulation and a second active ingredient comprising 50 to 150 mg dinotefuran per ml of total volume of formulation, wherein the formulation further comprises (I) permethrin or phenothrin and (ii) an insect growth regulator comprising pyriproxyfen or methoprene, and wherein the first active ingredient and the second active ingredient are packaged with said permethrin or phenothrin, but isolated from interacting with said permethrin or phenothrin.
2. The topical formulation of claim 1 , wherein the active ingredients are isolated via the use of granulation, encapsulation, micelles, or encapsulated microbeads.
3. The topical formulation of claim 1 , wherein the formulation is not irritating to cats and dogs and is effective to kill endoparasites and ectoparasites with applications of less than 10 ml.
4. A method for treating endoparasitic or ectoparasitic infestation in an animal, the method comprising applying the topical formulation of claim 1 to the animal.
5. The method of claim 4 wherein the animal is a cat or a dog.
6. A topical formulation comprising a first active ingredient comprising approximately 0.2 to 1.75 mg ivermectin per ml of total volume of formulation and a second active ingredient comprising 50 to 150 mg dinotefuran per ml of total volume of formulation, wherein the formulation further comprises (i) permethrin or phenothrin and (ii) an insect growth regulator comprising pyriproxyfen or methoprene, wherein the ivermectin and dinotefuran are packaged in a first container, permethrin or phenothrin is packaged in a second container, and the insect growth regulator is packaged in either the first container or the second container, the first container. packaged in a manner in which it is separated from the second container, in order to prevent interaction with the second container prior to administrating the topical formulation.
7. The topical formulation of claim 6 , wherein the first and second containers are packaged together but separated by at least one barrier to prevent the interaction of the first container with the second container.
8. The topical formulation of claim 6 , wherein the formulation is not irritating to cats and dogs and is effective to kill endoparasites and ectoparasites with applications of less than 10 ml.
9. A method for treating endoparasitic or ectoparasitic infestation in an animal, the method comprising applying the topical formulation of claim 6 to the animal.
10. The method of claim 4 , wherein the animal is a cat or dog.