Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor

1. A compound of formula 1 and a pharmaceutically acceptable salt thereof:

wherein, R 1 , R 2 , R 3 , R 4 and R5 are each independently selected from the group consisting of a hydrogen; a halogen; C 1 –C 3 -alkyl substituted or not substituted by halogens; NO 2 , NH 2 , OH, OMe, CO 2 H or CN and A is selected from CH 3 or NH 2 , wherein the compound of formula 1 is selected from the group consisting of:

6-(3-methyl-5-phenyl-[1,2,4]triazole-1-yl)-pyridine-3-sulfonic acid amide;

6-[5-(4-fluoro-phenyl)-3-methyl-[1,2,4]triazole-1-yl]-pyridine-3-sulfonic acid amide;

6-[5-(4-chloro-phenyl)-3-methyl-[1,2,4]triazole-1-yl]-pyridine-3-sulfonic acid amide;

6-[5-(4-bromo-phenyl)-3-methyl-[1,2,4]triazole-1-yl]-pyridine-3-sulfonic acid amide;

6-(3-methyl-5-p-toly-[1,2,4]triazole-1-yl)- pyridine-3-sulfonic acid amide;

6-[5-(4-methoxy-phenyl)-3-methyl-[1,2,4]triazole-1-yl]- pyridine-3-sulfonic acid amide;

6-[5-(3-fluoro-phenyl)-3-methyl-[1,2,4]triazole-1-yl]- pyridine-3-sulfonic acid amide;

6-[5-(3-chloro-phenyl)-3-methyl-[1,2,4]triazole-1-yl]- pyridine-3-sulfonic acid amide;

6-[5-(3,5-dimethoxy-phenyl)-3-methyl-[1,2,4]triazole-1-yl]- pyridine-3-sulfonic acid amide; and

2-[5-(4-bromo-phenyl)-3-methyl-[1,2,4]triazole-1-yl]-5-methanesulfonyl-pyridine.