Method for preparing medical dressings
Healing of wounds is promoted by covering and contacting the wound with a dressing that has been infused with a suspension of a starch hydrolysate containing ascorbic acid and other components, such as collagen and alpha-tocopherol acetate. In suspension, in the infused dressing or carrier the combinations avoid the tendency of the components to separate thereby causing them to remain in suspension and to form a stable gel or dressing. Combining the starch hydrolysate and other components for delivery via the infused dressing allows for a more stable suspension for delivering the components to the wound. The infused dressing also permits the inclusion components that would be otherwise difficult to combine in a suspension. Wounds, in particular those occurring in the skin as second and third degree burns, stasis ulcers, trophic lesions, such as decubitus ulcers, severe cuts and abrasions which are commonly resistant to the natural healing process, may be treated with the infused dressing of the present invention.
1 - 24 . (canceled)
25 . A method for preparing a medical dressing, comprising the steps of
preparing a suspension comprising starch hydrolysate having a dextrose equivalent (DE) less than 35, ascorbic acid, alpha-tocopherol and collagen;
infusing said suspension into an infusible liquid phase dressing; and
processing the infused dressing into a medical dressing in the form of a film dressing or a semi-solid gel dressing.
26 . The method according to claim 25 , wherein the alpha-tocopherol is present in the suspension in a concentration of about 8-10 μg/ml.
27 . The method according to claim 25 , wherein the collagen is collagen type I.
28 . The method according to claim 25 , wherein the collagen is present in the suspension in a concentration of about 0.2 to 2 μg/cm 3 .
29 . The method according to claim 25 , wherein the collagen is derived from human placenta.
30 . The method according to claim 25 , wherein the collagen is bovine collagen.
31 . The method according to claim 25 , wherein the ascorbic acid is present in the suspension in a concentration of about 0.5-20 percent by weight.
32 . The method according to claim 25 , wherein the ascorbic acid is present in the suspension in a concentration of about one percent by weight.
33 . The method according to claim 25 , wherein the starch hydrolysate has a DE between about 5 and about 25.
34 . The method according to claim 25 , wherein the starch hydrolysate has a DE between about 9 and about 13.
35 . The method according to claim 25 , wherein the processing step comprises drying the infused dressing to form the film dressing or semi-solid gel dressing.
36 . The method according to claim 25 , wherein the processing step comprises treating the infused dressing on a substrate to form the film dressing or semi-solid gel dressing.
37 . The method according to claim 25 , wherein the infusible liquid phase dressing is a hydrocolloid dressing.
38 . The method according to claim 25 , wherein the infusible liquid phase dressing is a hydrogel dressing.
39 . The method according to claim 25 , wherein the infusible liquid phase dressing is a polyacrylate dressing.
40 . The method according to claim 25 , wherein the infusible liquid phase dressing is a hydrophilic foam dressing.
41 . The method according to claim 25 , further comprising the step of inserting the medical dressing into a single-use, impermeable package.
42 . A method for preparing a medical dressing, comprising the steps of
preparing a suspension comprising starch hydrolysate having a dextrose equivalent (DE) between about 9 and about 13, ascorbic acid, alpha-tocopherol and collagen;
infusing said suspension into an infusible liquid phase dressing; and
processing the infused dressing into a medical dressing in the form of a film dressing or a semi-solid gel dressing;
wherein
the alpha-tocopherol is present in the suspension in a concentration of about 8-10 μg/ml,
the collagen is collagen type 1, is present in the suspension in a concentration of about 0.2 to 2 μg/cm 3 , and is derived from human placenta,
the ascorbic acid is present in the suspension in a concentration of about one percent by weight,
the infusible liquid phase dressing is a hydrocolloid dressing, and
the processing step comprises drying the infused dressing to form the film dressing or semi-solid gel dressing.
43 . The method according to claim 42 , further comprising the step of inserting the medical dressing into a single-use package.
44 . A method for preparing a medical dressing, comprising the steps of
preparing a suspension comprising starch hydrolysate having a dextrose equivalent (DE) between about 9 and about 13, ascorbic acid, alpha-tocopherol and collagen;
infusing said suspension into an infusible liquid phase dressing;
processing the infused dressing into a medical dressing in the form of a film dressing or a semi-solid gel dressing; and
inserting the medical dressing into a single-use, impermeable package;
wherein
the alpha-tocopherol is present in the suspension in a concentration of about 8-10 μg/ml,
the collagen is collagen type I, is present in the suspension in a concentration of about 0.2 to 2 μg/cm 3 , and is derived from human placenta,
the ascorbic acid is present in the suspension in a concentration of about one percent by weight,
the infusible liquid phase dressing is a hydrocolloid dressing, and
the processing step comprises drying the infused dressing to form the film dressing or semi-solid gel dressing.