Nitroderivatives of cardiovascular agents
View Patent ↗Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C 1 are two bivalent radicals. The precursors of the radicals B and B 1 are such as to meet the pharmacological test reported in the description.
1. Compounds or their salts having the following general formula (I):
A-B-T c -Y—NO 2 (I)
wherein:
A=R-T 1 -, wherein
R is the radical of a drug having formula R-T 1 -H or R-T 1 -OH selected from the group of cardiovascular drugs consisting of:
ACE-inhibitors: captopril, enalapril, lisinopril, losartan and ramipril;
beta blockers: alprenolol, atenolol, bupranolol, labetalol, metipranolol, metoprolol, pindolol, propanolol, timolol;
antithrombotic and vasoactive drugs: argatroban, clopidogrel, dipyridamole, iloprost, ozagrel, triflusal;
antidiabetic drugs: nicotinamide, tolrestat;
T 1 =(CO) or X wherein:
X=O, S, N, NR 1C
wherein R 1C is H or a linear or branched C 1 -C 5 alkyl,
B=-T B -X 2 -T BI - wherein
T B and T BI are equal or different, are
T B =(CO) when T 1 is X, T B =X when T 1 is (CO), X being as above defined;
T BI =(CO) or X, X being as above defined;
X 2 is a bivalent bridging group between T B and T B1 , wherein -T B -X 2 -T BI - is selected from:
T C =(CO) when T B1 is X, or
T C =X when T B1 is (CO), X being as above defined;
Y is Y 0 =an alkylenoxy group R′O wherein R′ is linear or branched C 1 -C 20 alkyl.
2. A method for the treatment of pathologies associated with stress oxidative and/or endothelial dysfunction comprising administering compounds or salts according to claim 1 .
3. Pharmaceutical formulation containing as active principle the compounds or salts thereof of claim 1 .