IP Library › Patent Application 11237086
Patent Application
App. No. 11/237,086

Localization of A2B AdoR on human normal and diseased tissue: the use of anti-A2B antibody to diagnose and treat human tumors

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Quick Facts
Patent No.
US None
App. No.
11/237,086
Abstract

The invention provides methods of detection, prevention, amelioration, and treatment for angiogenesis, including angiogenesis associated with colon cancer and glioma. The methods comprise the use of an anti-A 2B antibody.

Claims (20)

1 . A method of detecting the presence of angiogenesis in a mammal comprising:

contacting a biological sample from the mammal with an anti-A 2B antibody that specifically binds an A 2B receptor under conditions that allow formation of an immunocomplex between the antibody and the A 2B receptor;

contacting a control sample with an anti-A 2B antibody that specifically binds an A 2B receptor under conditions that allow formation of an immunocomplex between the antibody and the A 2B receptor; and

detecting immunocomplexes in both samples;

wherein detection of a greater amount of immunocomplexes in the sample from the mammal than in the control sample indicates the presence of angiogenesis in the mammal.

2 . The method of claim 1 , wherein the biological sample is a tissue sample.

3 . The method of claim 1 , wherein the antibody is polyclonal.

4 . The method of claim 1 , wherein the antibody is monoclonal.

5 . The method of claim 1 , wherein the angiogenesis is associated with a glioma.

6 . The method of claim 1 , wherein the angiogenesis is associated with colon cancer.

7 . The method of claim 1 , wherein the mammal is a human.

8 . A method of detecting the presence of angiogenesis in a mammal comprising:

contacting a tissue sample from the mammal with an anti-A 2B antibody that specifically binds an A 2B receptor under conditions that allow formation of an immunocomplex between the antibody and the A 2B receptor; and

detecting immunocomplexes;

wherein, the detection of immunocomplexes on capillaries of the tissue sample indicates the presence of angiogenesis.

9 . The method of claim 8 , wherein the antibody is polyclonal.

10 . The method of claim 8 , wherein the antibody is monoclonal.

11 . The method of claim 8 , wherein the angiogenesis is associated with a glioma.

12 . The method of claim 8 , wherein the angiogenesis is associated with colon cancer.

13 . The method of claim 8 , wherein the mammal is a human.