Medical device with bioactive agent

1. A prosthetic valve for selectively permitting fluid flow through a body vessel in a first direction and substantially preventing fluid flow through said body vessel in a second, opposite direction, said prosthetic valve comprising:

a support frame having radially expanded and radially compressed configurations;

a first bioremodellable leaflet attached to the support frame and including a first base portion attached to the support frame and a first free edge that is moveable within said body vessel;

a second bioremodellable leaflet attached to the support frame and including a second base portion attached to the support frame and a second free edge that is moveable within said body vessel; and

an antiproliferative agent associated with at least one of the first and second free edges;

wherein the first and second free edges cooperatively define a valve orifice that opens and closes in response to movement of the first and second free edges; and

wherein the first and second base portions are free of the antiproliferative agent such that remodelling of the at least one free edge with which the antiproliferative agent is associated is delayed with respect to remodelling of the first and second base portions.

2. The prosthetic valve according to claim 1 , wherein at least one of the first and second leaflets comprises an edge that at least partially defines an opening for permitting a controlled amount of said fluid flow through said body vessel in said second, opposite direction.

3. The prosthetic valve according to claim 2 , wherein the at least one of the first and second leaflets defines a flap capable of substantially covering the opening.

4. The prosthetic valve according to claim 1 , wherein the first and second leaflets comprise an extracellular matrix material.

5. The prosthetic valve according to claim 1 , wherein the first and second leaflets comprise small intestine submucosa.