IP Library Granted Patent US 9,078,428
Granted Patent B2
US 9,078,428 · App. 11/246,919 · Granted Jul 14, 2015

Systems, methods, compositions and solutions for perfusing an organ

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Quick Facts
Patent No.
US 9,078,428
App. No.
11/246,919
Granted
Jul 14, 2015
Kind
B2
Abstract

The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.

Claims (31)

1. A composition comprising in an aqueous medium:

adenosine at a concentration of about 675 mg/1500 mL to about 825 mg/1500 mL,

calcium chloride dehydrate in an amount of about 2100 mg/1500 mL to about 2600 mg/1500 mL,

glycine in an amount of about 315 mg/1500 mL to about 385 mg/1500 mL,

L-alanine in an amount of about 150 mg/1500 mL to about 200 mg/1500 mL,

L-arginine in an amount of about 600 mg/1500 mL to about 800 mg/1500 mL,

L-aspartic acid in an amount of about 220 mg/1500 mL to about 270 mg/1500 mL,

L-glutamic acid in an amount of about 230 mg/1500 mL to about 8290 mg/1500 mL,

L-histidine in an amount of about 200 mg/1500 mL to about 250 mg/1500 mL,

L-isoleucine in an amount of about 100 mg/1500 mL to about 130 mg/1500 mL,

L-leucine in an amount of about 300 mg/1500 mL to about 380 mg/1500 mL,

L-methionine in an amount of about 50 mg/1500 mL to about 65 mg/1500 mL,

L-phenylalanine in an amount of about 45 mg/1500 mL to about 60 mg/1500 mL,

L-proline in an amount of about 110 mg/1500 mL to about 140 mg/1500 mL,

L-serine in an amount of about 80 mg/1500 mL to about 105 mg/1500 mL,

L-threonine in an amount of about 60 mg/1500 mL to about 80 mg/1500 mL,

L-tryptophan in an amount of about 30 mg/1500 mL to about 40 mg/1500 mL,

L-tyrosine in an amount of about 80 mg/1500 mL to about 110 mg/1500 mL,

L-valine in an amount of about 150 mg/1500 mL to about 190 mg/1500 mL,

lysine acetate in an amount of about 200 mg/1500 mL to about 250 mg/1500 mL,

magnesium sulfate heptahydrate in an amount of about 535 mg/1500 mL to about 635 mg/1500 mL,

potassium chloride in an amount of about 200 mg/1500 mL to about 210 mg/1500 mL,

sodium chloride in an amount of about 11.1 g/1500 mL to about 11.6 g/1500 mL,

dextrose in an amount of about 25 g/1500 mL to about 120 g/1500 mL,

epinephrine in an amount of about 0.25 mg/1500 mL to about 1.0 mg/1500 mL,

insulin in an amount of about 75 IU/1500 mL to about 150 IU/1500 mL,

one or more vitamins in an amount of about 1 mg/1500 mL to about 30 mg/1500 mL,

methylprednisolone sodium succinate in an amount of about 200 mg/1500 mL to 500 mg/1500 mL,

sodium bicarbonate in an amount of about 10 mEq/1500 mL to 25 mEq/1500 mL,

mannitol in an amount of about 12.5 g/1500 mL, and

sodium glycerophosphate in an amount of about 900 mg/1500 mL.

Assignments (7)
SECURITY INTEREST Recorded Jul 29, 2022
From: TRANSMEDICS, INC.
To: CANADIAN IMPERIAL BANK OF COMMERCE
Reel/Frame 060677/0520 →
RELEASE OF SECURITY INTEREST Recorded Jul 25, 2022
From: ORBIMED ROYALTY OPPORTUNITIES II, LP
To: TRANSMEDICS, INC.
Reel/Frame 060610/0023 →
SECURITY INTEREST Recorded Jun 22, 2018
From: TRANSMEDICS, INC.
To: ORBIMED ROYALTY OPPORTUNITIES II, LP
Reel/Frame 046179/0223 →
RELEASE OF SECURITY INTEREST Recorded Jun 22, 2018
From: HERCULES CAPITAL, INC. (F/K/A HERCULES TECHNOLOGY GROWTH CAPITAL, INC.)
To: TRANSMEDICS, INC.
Reel/Frame 046176/0714 →
PATENT GRANT OF SECURITY INTEREST Recorded Apr 8, 2011
From: TRANSMEDICS, INC.
To: HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
Reel/Frame 026101/0020 →
SECURITY AGREEMENT Recorded Mar 9, 2009
From: TRANSMEDICS, INC.
To: HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
Reel/Frame 022367/0662 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2006
From: HASSANEIN, WALEED; LEZBERG, PAUL; KHAYAL, TAMER
To: TRANSMEDICS, INC.
Reel/Frame 017508/0645 →