IP Library › Granted Patent US 7,344,705
Granted Patent B2
US 7,344,705 · App. 11/252,659 · Granted Mar 18, 2008

Composition comprising low density microspheres

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Quick Facts
Patent No.
US 7,344,705
App. No.
11/252,659
Granted
Mar 18, 2008
Kind
B2
Abstract

Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.

Claims (4)

1. A composition comprising low density microspheres, said microspheres comprising a polymer and having a void containing the vapor of a volatile liquid perfluorocarbon, wherein said microspheres, when combined with an aqueous solution to form a contrast agent, are suitable for administration to a patient either orally, rectally or by injection, and further wherein said microspheres have an internal void volume which is at least about 75% of the total volume of said microspheres.

2. The composition of claim 1 , wherein said microspheres have a void volume of at least about 80% of the total volume of said microspheres.

3. The composition of claim 1 , wherein said microspheres have a void volume of at least about 85% of the total volume of said microspheres.

4. The composition of claim 1 , wherein said microspheres have a void volume of at least about 90% of the total volume of said microspheres.

Assignments (12)
RELEASE OF SECURITY INTEREST IN CERTAIN PATENTS Recorded Mar 30, 2017
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: LANTHEUS HOLDINGS, INC.; LANTHEUS MEDICAL IMAGING, INC.; LANTHEUS MI REAL ESTATE, LLC
Reel/Frame 042115/0715 →
ASSIGNMENT OF SECURITY INTEREST IN PATENTS Recorded Jul 3, 2013
From: BMO HARRIS BANK N.A.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ASSIGNEE
Reel/Frame 030740/0335 →
RELEASE OF PATENT SECURITY AGREEMENT Recorded May 13, 2010
From: ABLECO FINANCE LLC
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 024380/0363 →
SECURITY AGREEMENT Recorded May 13, 2010
From: LANTHEUS MEDICAL IMAGING, INC.
To: HARRIS N.A., AS COLLATERAL AGENT
Reel/Frame 024390/0733 →
MERGER Recorded Oct 28, 2009
From: IMARX PHARMACEUTICAL CORP.
To: DUPONT CONTRAST IMAGING INC.
Reel/Frame 023433/0092 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2009
From: UNGER, EVAN C.
To: IMARX PHARMACEUTICAL CORP.
Reel/Frame 023433/0064 →
CHANGE OF NAME Recorded Oct 28, 2009
From: DUPONT CONTRAST IMAGING INC.
To: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
Reel/Frame 023433/0112 →
CHANGE OF NAME Recorded Oct 28, 2009
From: IMARX PHARMACEUTICAL CORP.
To: DUPONT CONTRAST IMAGING INC.
Reel/Frame 023433/0122 →
CONFIRMATORY ASSIGNMENT Recorded Oct 28, 2009
From: UNGER, EVAN C.
To: IMARX PHARMACEUTICAL CORP.
Reel/Frame 023433/0150 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 27, 2009
From: UNGER, EVAN C.
To: IMARX PHARMACEUTICAL CORP.
Reel/Frame 023157/0760 →
CHANGE OF NAME Recorded Mar 6, 2008
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 020609/0497 →
GRANT OF SECURITY INTEREST Recorded Jan 17, 2008
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: ABLECO FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 020371/0523 →