IP Library › Patent Application 11256445
Patent Application
App. No. 11/256,445

Liposome loading with metal ions

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
11/256,445
Abstract

This invention relates to encapsulation of drugs and other agents into liposomes.

Claims (19)

1 . A composition comprising liposomes containing an internal solution, the internal solution comprising one or more encapsulated transition metal ions and one or more encapsulated therapeutic agents, provided that if the one or more therapeutic agents is solely doxorubicin, the one or more encapsulated metal ions is not solely manganese, wherein the liposomes do not comprise an ionophore.

2 . The composition of claim 1 , wherein the internal solution comprises a metal compatible solution.

3 . (canceled)

4 . The composition of claim 1 , further comprising in an external solution to the liposome.

5 . The composition of claim 4 , wherein the external solution and external surfaces of the liposomes contain substantially no uncomplexed metal ions.

6 . The composition of claim 5 , wherein the external solution comprises a metal chelating agent.

7 . The composition of claim 4 , wherein the external solution and the internal solution have substantially the same pH.

8 . The composition of claim 1 , wherein the liposomes are of low cholesterol.

9 . The composition of claim 1 , wherein the one or more metal ions are first transition series metal ions.

10 . The composition of claim 1 , wherein the one or more metal ions are selected from the group consisting of: Fe, Co, Ni, Cu, Zn, V, Ti, Cr, Rh, Ru, Mo, and Pd ions.

11 . The composition of claim 1 , wherein the one or more metal ions are selected from the group consisting of: Fe, Co, Cu and Zn ions.

12 . The composition of claim 1 , wherein the one or more metal ions are selected from the group consisting of: Zn, Co, and Cu ions.

13 . The composition of claim 1 , wherein the one or more metal ions comprise Cu ions.

14 . The composition of claim 10 , wherein the internal solution further comprises Mn ions.

15 . The composition of claim 1 , wherein the pH of the internal solution is in the range of about 6.0 to about 8.5.

16 . The composition of claim 1 , wherein the liposomes comprise one or more lipids that are negatively charged at physiological pH.

17 . The composition of claim 16 , wherein the one or more negatively charged lipids are selected from PG and PI.

18 . The composition of claim 1 , wherein the therapeutic agent is an antineoplastic agent.

19 - 43 . (canceled)

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2006
From: TARDI, PAUL; JOHNSTONE, SHARON; WEBB, MURRAY; BALLY, MARCEL; ABRAHAM, SHEELA
To: CELATOR PHARMACEUTICALS, INC.
Reel/Frame 017744/0382 →