Method and device for local cooling within an organ using an intravascular device
View Patent ↗A method is disclosed for cooling a limited portion of a body organ by placing a cooling device into a blood vessel within a target organ; and activating the cooling device to cool tissue proximate the cooling device to a temperature below +34 degrees Centigrade. The blood vessel can be a vein or an artery and the cooling device can be a fixed diameter catheter or it can include a balloon. More particularly, the method of cooling can provide a method for treating injured ischemic and infarcted tissue by placing a device capable of passage through the vasculature into a target organ, wherein the device is capable of providing sufficient thermal exchange at a working region thereof to cool adjacent tissue; and activating the device to cool adjacent tissue to a temperature in the range of 0 degrees Centigrade to +36 degrees Centigrade. The method can further include placement of a second device capable of passage through the vasculature into the target organ, wherein the second device is capable of at least partially removing a blockage from a blood vessel.
1. A method for treating injured ischemic and infarcted tissue comprising:
positioning a first independent device within a vein of a target organ, wherein the first device has a cooling balloon capable of providing sufficient thermal exchange to cool adjacent tissue;
positioning a second independent device within an artery of the target organ, the artery having an endogenous arterial blockage therein, the second device being positioned proximate the arterial blockage and being capable of at least partially removing the arterial blockage from the artery, the first device being positioned within the vein of the target organ at a location proximate the arterial blockage;
activating the first device to cool adjacent tissue to a temperature in the range of 0 degrees Centigrade to +36 degrees Centigrade; and
at least partially removing the arterial blockage from the artery using the second device.
2. The method of claim 1 , wherein the first device is a catheter.
3. The method of claim 1 , wherein the working region of the first device is a balloon element.
4. A method for treating injured ischemic and infarcted tissue comprising:
placing a first catheter-based device capable of passage through the venous system into a vein of a target organ proximate an arterial blockage within an artery of the target organ, wherein the first device is capable of providing sufficient thermal exchange at a working region thereof to cool adjacent tissue, wherein the working region of the first catheter-based device is a cooling balloon element;
activating the device to cool adjacent tissue to a temperature in the range of 0 degrees Centigrade to +36 degrees Centigrade; and
placing a second catheter-based device capable of passage through the arterial system into an artery of the target organ proximate the location of the first catheter-based device, wherein the second catheter-based device is capable of at least partially removing the arterial blockage from the artery of the target organ.
5. The method of claim 4 , wherein the arterial blockage is an endogenous arterial blockage.
6. The method of claim 5 , wherein the endogenous arterial blockage is a blood clot.