Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine

1. A process of preparing , a compound of formula (XI):

the process comprising the steps of:

(a) reacting pyrazole with methyl 6-cholonicotinate in the presence of a strong base to provide 6-pyrazole-1-yl-nioctinic acid methyl ester (compound of formula (XI-a));

(b) reducing the compound of formula (XI-a) prepared in Step (a) with a reducing agent to provide (6-pyrazole-1-yl-pyridin3-yl)-methanol (compound of formula (XI-b));

(c) halogenating the compound of formula (XI-b) prepared in Step (b) with a chlorinating agent to provide 5-chloromethyl-2-pyrazole-1-yl-pyridine (compound of formula (XI-c));

(d) adding the compound of formula (XI-c), prepared in Step (c) with a compound of formula (XI-e);

 wherein A and B are both hydrogen or taken together with with th carbon atoms to which they are attached are selected from aryl, substituted aryl, heterocyclic, or substituted heterocyclic, to provide a compound of formula (XI-d);

 and

(e) hydrolying a compound of formula (XI-d), prepared in Step (d), with a base.

2. The process of claim 1 , wherein for the step of reacting, the strong base is sodium hydride.

3. The process of claim 1 , wherein for the step of reducing, the reducing agent is sodium borohydride.

4. The process of claim 1 , wherein for the step of halogenating the chlorinating agent is thiony chloride.

5. The process of claim 1 , wherein in step (c) the base is ammonia.