Pro-fibrotic coatings

1. An implantable medical article comprising a pro-fibrotic coating, the pro-fibrotic coating comprising (a) collagen, (b) thromboresistant agent, and (c) a reacted photogroup, wherein the coating comprises a first coated layer comprising free-radically polymerized thromboresistant agent that is positioned between a second coated layer comprising the collagen and a surface of the article, and the coating is formed by applying the collagen and thromboresistant agent independently to the article.

2. The implantable medical article of claim 1 wherein the coating is formed from a composition comprising collagen comprising a pendent photoreactive group.

3. The implantable medical article of claim 1 wherein the reacted photogroup bonds collagen to the thromboresistant agent.

4. The implantable medical article of claim 1 wherein the collagen comprises collagen type I.

5. The implantable medical article of claim 1 wherein the coating is formed from a composition comprising a compound comprising a photoreactive group, collagen, and a thromboresistant agent, and the compound comprising the photoreactive group is independent of the collagen or the thromboresistant agent.

6. The implantable medical article of claim 5 wherein the first coated layer is formed from a composition comprising a free-radically polymerizable thromboresistant agent and a polymerization initiator.

7. The implantable medical article of claim 5 wherein the compound comprises two or more photoreactive groups.

8. The implantable medical article of claim 6 wherein the collagen comprises a pendent polymerized group.

9. The implantable medical article of claim 8 comprising a layer of polymerized collagen.

10. The implantable medical article of claim 1 wherein the thromboresistant agent comprises a polymer.

11. The implantable medical article of claim 1 wherein the thromboresistant agent is present in the coating in an amount of 10% (wt) or greater.

12. The implantable medical article of claim 10 wherein the thromboresistant polymer comprises poly(ethylene glycol).

13. The implantable medical article of claim 1 wherein the pro-fibrotic coating is less than 5 μm in thickness.

14. The implantable medical article of claim 1 comprising a vascular occlusion device.

15. The implantable medical article of claim 1 comprising a cardiac patch.

16. The implantable medical article of claim 12 wherein a portion of the coating is formed from a composition comprising poly(ethylene glycol)-triacrylate macromer.

17. The implantable medical article of claim 1 wherein the coating is formed from a first composition comprising the thromboresistant agent a concentration in the range of 10-20% wt, and a second composition comprising the collagen at a concentration in the range of 5-20% wt.

18. The implantable medical article of claim 1 comprising a priming layer located between the first layer and the surface of the device, the priming layer comprising the reacted photogroup.

19. The implantable medical article of claim 1 wherein the free-radically polymerized thromboresistant agent comprises a free radically polymerized group selected from the group consisting of vinyl groups, acrylate groups, methacrylate groups, ethacrylate groups, 2-phenyl acrylate groups, acrylamide groups, methacrylamide groups, itaconate groups, and styrene groups.

20. The implantable medical article of claim 1 which is formed from material selected from the group consisting of poly(urethanes), poly(acrylates), poly(methacrylates), poly(vinylpyrrolidone), cellulose acetate, ethylene vinyl alcohol copolymers, poly(acrylonitrile), poly(vinylacetate), cellulose acetate butyrate, nitrocellulose, copolymers of urethane/carbonate, and copolymers of styrene/maleic acid.

21. The implantable medical article of claim 1 which is formed from material selected from the group consisting of platinum, gold, tungsten, rhenium, palladium, rhodium, ruthenium, titanium, nickel, stainless steel, titanium/nickel alloy, and nitinol alloy.