Salt forms of poorly soluble probucol esters and ethers
View Patent ↗Organic amine salts of compounds of the formula: and their pharmaceutically acceptable salts, and uses in medical therapy are provided.
1. A method for the treatment of rheumatoid arthritis, comprising administering to a host in need thereof a pharmaceutical composition comprising a compound of the formula:
wherein:
R 1 and R 2 are independently hydrogen or alkyl or taken together to form a carbonyl; and
Y is (CH 2 ) 0-5 ; when R 1 and R 2 taken together form a carbonyl, Y is (CH 2 ) 1-5 ;
together with meglumine and a pharmaceutically acceptable carrier.
2. A method for the treatment of atherosclerosis, comprising administering to a host in need thereof a pharmaceutical composition comprising a compound of the formula:
wherein:
R 1 and R 2 are independently hydrogen or alkyl or taken together to form a carbonyl; and
Y is (CH 2 ) 0-5 ; when R 1 and R 2 taken together form a carbonyl, Y is (CH 2 ) 1-5 ;
together with meglumine and a pharmaceutically acceptable carrier.
3. A method for treatment of hypercholesterolemia, comprising administering to a host in need thereof a pharmaceutical composition comprising a compound of the formula:
wherein:
R 1 and R 2 are independently hydrogen or alkyl or taken together to form a carbonyl; and
Y is (CH 2 ) 0-5 ; when R 1 and R 2 taken together form a carbonyl, Y is (CH 2 ) 1-5 ;
together with meglumine and a pharmaceutically acceptable carrier.
4. A method for treatment of hyperlipidemia, comprising administering to a host in need thereof a pharmaceutical composition comprising a compound of the formula:
wherein:
R 1 and R 2 are independently hydrogen or alkyl or taken together to form a carbonyl; and
Y is (CH 2 ) 0-5 ; when R 1 and R 2 taken together form a carbonyl, Y is (CH 2 ) 1-5 ;
together with meglumine and a pharmaceutically acceptable carrier.
5. The method of claim 1 , wherein R 1 and R 2 are taken together to form a carbonyl.
6. The method of claim 5 , wherein Y is (CH 2 ) 2 .
7. The method of claim 1 , wherein R 1 and R 2 are each hydrogen.
8. The method of claim 7 , wherein Y is (CH 2 ) 0 .
9. The method of claim 7 , wherein Y is (CH 2 ) 2 .
10. The method of claim 2 , wherein R 1 and R 2 are taken together to form a carbonyl.
11. The method of claim 10 , wherein Y is (CH 2 ) 2 .
12. The method of claim 2 , wherein R 1 and R 2 are each hydrogen.
13. The method of claim 12 , wherein Y is (CH 2 ) 0 .
14. The method of claim 12 , wherein Y is (CH 2 ) 2 .
15. The method of claim 3 , wherein R 1 and R 2 are taken together to form a carbonyl.
16. The method of claim 15 , wherein Y is (CH 2 ) 2 .
17. The method of claim 3 , wherein R 1 and R 2 are each hydrogen.
18. The method of claim 17 , wherein Y is (CH 2 ) 0 .
19. The method of claim 17 , wherein Y is (CH 2 ) 2 .
20. The method of claim 4 , wherein R 1 and R 2 are taken together to form a carbonyl.
21. The method of claim 20 , wherein Y is (CH 2 ) 2 .
22. The method of claim 4 , wherein R 1 and R 2 are each hydrogen.
23. The method of claim 22 , wherein Y is (CH 2 ) 0 .
24. The method of claim 22 , wherein Y is (CH 2 ) 2 .