85kDa neisserial antigen
View Patent ↗An 85 kDa antigen from Neisseria meningitidis and Neisseria gonorrhoeae has been cloned, sequenced and expressed. The antigen is common to diverse strains, serogroups and serotypes of N. meningitidis , and also to N. gonorrhoeae, N. polysaccharia and N. lactamica . The protein sequences of N. meningitidis (serogroups A and B) and N. gonorrhoeae are highly homologous.
1. An isolated oligopeptide consisting of
the amino acid sequence comprising SEQ ID NO:89.
2. A composition comprising the oligopeptide of claim 1 , and a pharmaceutically acceptable vehicle.
3. The composition of claim 2 , further comprising one or more immunogenic components selected from the group consisting of (a) a protective antigen against Neisseria meningitidis serogroup B; (b) a protective antigen against Neisseria gonorrhoeae ; (c) a protective antigen against Neisseria meningitidis serogroup A; (d) a protective antigen against Neisseria meningitidis serogroup C; (e) a protective antigen against Neisseria meningitidis serogroup Y; (f) a protective antigen against Neisseria meningitidis serogroup W; (g) a protective antigen against Haemophilus influenzae ; (h) a protective antigen against pneumococcus; (i) a protective antigen against diphtheria; (j) a protective antigen against tetanus; (k) a protective antigen against whooping cough; (l) a protective antigen against Helicobacter pylori ; (m) a protective antigen against polio; and (n) a protective antigen against hepatitis B virus.