Heteroaryl compounds

1. A compound represented by formula (II):

or a pharmaceutically acceptable salt thereof, wherein:

V is N and Q and U are CR g ;

X 1 is selected from the group consisting of:

represents the point of attachment;

Y is (CH(R g )) m , C(O), C(NR), O, S, S(O), S(O) 2 , N(OR k ), N(R k ), or absent;

R 1 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl, provided that R 1 is not tetrazolyl, o-methoxyphenyl, 3,4,5-trimethoxyphenyl, a substituted or unsubstituted 4,5-dihydro-1H-benzo[g]indazolyl, a substituted 5-oxo-1,2,3,9b-tetrahydro-pyrrolo[2,1-a]isoindolyl;

R 3 is R g , —C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(O)R c , —C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(S)R c , —C(NR)R c , —OC(NR)R c , —SC(NR)R c , —NR k C(NR)R c , —SO 2 R c , —S(O)R c , —NR k SO 2 R c , —OS(O) 2 R c , —OP(O)R c R c , or —P(O)R c R c ;

R 2 and R 4 for each occurrence, are independently, H, an optionally substituted alkyl, an optionally substituted alkylcarbonyl, —OR k , —SR k , —NR h R j , hydroxylalkyl, —C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(O)R c , —C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(S)R c , —C(NR)R c , —OC(NR)R c , —SC(NR)R c , —NR k C(NR)R c , —SO 2 R c , —S(O)R c , —NR k SO 2 R c , —OS(O) 2 R c , —OP(O)R c R c , —P(O)R c R c , halo, haloalkyl, aminoalkyl, mercaptoalkyl, cyano, nitro, nitroso, azide, an optionally substituted alkylcarbonylalkyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted heteroaryl, an optionally substituted heteroaralkyl, or isothionitro; or R 2 and R 4 taken together are ═O, ═S, or ═NR;

R 6 is H or an alkyl;

R c , for each occurrence, is independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl, haloalkyl, —OR k , —SR k , —NR h R j , hydroxylalkyl, alkylcarbonylalkyl, mercaptoalkyl, aminoalkyl, sulfonylalkyl, sulfonylaryl, or thioalkoxy;

R d , for each occurrence, is independently, H or a halo;

R g , for each occurrence, is independently, H;

R h and R j , for each occurrence, are independently H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl; or R h and R j taken together with the N to which they are attached is an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, or an optionally substituted heteroaryl;

R k , for each occurrence, is independently H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl;

G is a Hydrazide; Hydrazone; Hydrazine; Hydroxylamine; Oxime; Amide; Ester; Carbonate; Carbamate; Thiocarbamate; —NR k —C(NR)—NR k ; —NR k —C(O)—NR k —; —NR k —C(S)—NR k —; —NR k —S(O) 2 —NR k —; Phosphoryl; an optionally substituted -Cyclyl-; an optionally substituted -Heterocyclyl-; an optionally substituted -Aryl-; an optionally substituted -Heteroaryl-; an optionally substituted -Heteroarylalkyl-; an optionally substituted -Heteroaryl—NR k -; an optionally substituted -Heteroaryl-S—; an optionally substituted -Heteroarylalkyl-O—; —Si(OR k ) 2 —; —B(OR k )—; —C(NR)—NR k —; —N(R k )—CR g R g —C(O)—; —C(O)—ON(R k )—; —C(O)—N(R k )O—; —C(S)—ON(R k )—; —C(S)—N(R k )O—; —C(N(R k ))—ON(R k )—; —C(N(R k ))—NR k O—; —OS(O) 2 —N(R k )N(R k )—; —OC(O)—N(R k )N(R k )—; —OC(S)—N(R k )N(R k )—; —OC(N(R k ))—N(R k )N(R k )—; —N(R k )N(R k )S(O) 2 O—; —N(R k )N(R k )C(S)O—; —N(R k )N(R k )C(N(R k ))O—; —OP(O)(R c )O—; —N(R k )P(O)(R c )O—; —OP(O)(R c )N(R k )—; —N(R k )P(O)(R c )N(R k )—; —P(O)(R c )O—; —P(O)(R c )N(R k )—; —N(R k )P(O)(R c )—; —OP(O)(R c )—; —O-alkyl-heterocyclyl-N(R k )—; —N(R k )CHR g C(O)N(R k )CHR g C(O)—; —N(R k )CHR g C(O)—; —N(R k )C(O)CHR g —; or —C(O)N(R k )CHR g C(O)—; each of which is optionally substituted; or G is absent;

q is 0, 1, 2, 3, or 4;

m, for each occurrence, is independently 1, 2, 3, 4, 5, 6, 7, or 8;

n, for each occurrence, is independently 0, 1, 2, 3, 4, 5, 6, or 7; and

p, for each occurrence, is independently 0, 1, or 2.

2. The compound of claim 1 , wherein R 1 is an optionally substituted naphthyl, an optionally substituted anthracenyl, an optionally substituted indanyl, an optionally substituted fluorenyl, an optionally substituted indenyl, an optionally substituted azulenyl, an optionally substituted pyridyl, an optionally substituted 1-oxo-pyridyl, an optionally substituted furanyl, an optionally substituted benzo[1,3]dioxolyl, an optionally substituted benzo[1,4]dioxinyl, an optionally substituted thienyl, an optionally substituted pyrrolyl, an optionally substituted oxazolyl, an optionally substituted imidazolyl, an optionally substituted thiazolyl, an optionally substituted isoxazolyl, an optionally substituted quinolinyl, an optionally substituted pyrazolyl, an optionally substituted isothiazolyl, an optionally substituted pyridazinyl, an optionally substituted pyrimidinyl, an optionally substituted pyrazinyl, an optionally substituted triazinyl, an optionally substituted triazolyl, an optionally substituted thiadiazolyl, an optionally substituted isoquinolinyl, an optionally substituted indazolyl, an optionally substituted benzoxazolyl, an optionally substituted benzofuryl, an optionally substituted indolizinyl, an optionally substituted imidazopyridyl, an optionally substituted benzimidazolyl, an optionally substituted benzothiazolyl, an optionally substituted benzothiadiazolyl, an optionally substituted benzoxadiazolyl, an optionally substituted indolyl, an optionally substituted tetrahydroindolyl, an optionally substituted azaindolyl, an optionally substituted indazolyl, an optionally substituted imidazopyridyl, an optionally substituted quinazolinyl, an optionally substituted purinyl, an optionally substituted pyrrolo[2,3]pyrimidinyl, an optionally substituted pyrazolo[3,4]pyrimidinyl, or an optionally substituted benzo(b)thienyl; or

R 1 is a phenyl group which is optionally substituted with one or more substituents selected from the group consisting of a halo, hydroxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, cyano, nitro, mercapto, mercapto, imino, formyl, carbamido, carbamyl, carboxyl, thioureido, thiocyanato, sulfoamido, sulfonylalkyl, sulfonylaryl, alkyl, alkenyl, alkynyl, cycloalkyl, cyclyl, aryl, aralkyl, heterocycloalkyl, heterocyclyl, heteroaryl, heteroaralkyl, haloalkyl, aryloxy, hydroxyl, hydroxylalkyl, alkylcarbonyl, alkylcarbonylalkyl, alkoxycarbonyl, alkylcarbonyloxy, aryloxycarbonyl, heteroaryloxy, heteroaryloxycarbonyl, mercaptoalkyl, arylsulfonyl, aminoalkyl, alkylcarbonylamino, alkylaminocarbonyl, alkoxycarbonylamino, arylamino-substituted aryl, arylalkylamino, aralkylaminocarbonyl, amido, alkylaminosulfonyl, arylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, mercaptoalkoxy, SR 15 , S(O) 2 OR 15 , NR 15 R 16 , C 1 -C 2 perfluoroalkyl, C 1 -C 2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR 15 , C(O)NR 15 R 16 , OC(O)NR 15 R 16 , NR 15 C(O)NR 15 R 16 , C(NR 16 )NR 15 R 16 , NR 15 C(NR 16 )NR 15 R 16 , S(O) 2 NR 15 R 16 , R 17 , C(O)H, C(O)R 17 , NR 15 C(O)R 17 , Si(R 15 ) 3 , OSi(R 15 ) 3 , Si(OH) 2 R 15 , B(OH) 2 , P(O)(OR 15 ) 2 , S(O)R 17 , or S(O) 2 R 17 ,

wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cyclyl, aryl, aralkyl, heterocycloalkyl, heterocyclyl, heteroaryl, or heteroaralkyl, of each phenyl substituent of R 1 may be optionally substituted with alkyl, aryl, heteroaryl, halogen, hydroxyl, amino, mercapto, cyano, nitro, oxo (═O), thioxo (═S), or imino (═NR);

R 15 is independently hydrogen, C 1 -C 6 alkyl optionally substituted with cycloalkyl, aryl, heterocyclyl, or heteroaryl;

R 16 is independently hydrogen, C 3 -C 6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1 -C 4 alkyl or C 1 -C 4 alkyl substituted with C 3 -C 6 cycloalkyl, aryl, heterocyclyl or heteroaryl; and

R 17 is independently C 3 -C 6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1 -C 4 alkyl or C 1 -C 4 alkyl substituted with C 3 -C 6 cycloalkyl, aryl, heterocyclyl or heteroaryl;

wherein each C 3 -C 6 cycloalkyl, aryl, heterocyclyl, heteroaryl and C 1 -C 4 alkyl in each R 15 , R 16 and R 17 can optionally be substituted with halo, CN, C 1 -C 4 alkyl, OH, C 1 -C 4 alkoxy, COOH, C(O)OC 1 -C 4 alkyl, NH 2 , C 1 -C 4 alkylamino, or C 1 -C 4 dialkylamino.

3. The compound of claim 2 , wherein R 1 is an optionally substituted indanyl, an optionally substituted indolyl, an optionally substituted thienyl, an optionally substituted 2,3,4,9-tetrahydro-1H-carbazolyl.

4. The compound of claim 3 , wherein R 1 is 2,3-dimethyl-1H-indol-5-yl, 4,5-dimethyl-thien-2-yl, or 2,3,4,9-tetrahydro-1H-carbazol-6-yl.

5. The compound of claim 1 , wherein X 1 is a group represented by the following formula:

6. The compound of claim 2 , wherein Y is (CH(R g )) m , O, N(OR k ), NR k , or absent.

7. The compound of claim 6 , wherein Y is NR k and R k is H or a lower alkyl.

8. The compound of claim 6 , wherein each of R 2 and R 4 is independently, H or an alkyl.

9. The compound of claim 6 , wherein R 3 is H, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, cyano, halo, OR k , or NR h R j .

10. The compound of claim 9 , wherein R 3 is —OR k or —NR h R j , and R f , R h and R j are each, independently, H or alkyl.

11. The compound of claim 6 , wherein n is 0, 1, 2, or 3.

12. The compound of claim 6 , wherein G is —C(O)NHNH—, —NHNHC(O)—, —C(O)NR k NR k —, —NR k NR k C(O)—, —CH═N—NH—, —NH—N═CH—CR g ═N—NR k —, —NR k —N═CR g —, —NHNH—, —NR k NR k —, —NHO— —O—NH—, —O—NR k —, —NR k —O—, —CH═N—O—, —O—N═CH—, —CR g ═N—O—, —O—N═CR g —, —O—C(O)—NH—, —O—C(O)—NR k —, —O—C(S)—NH—, —NH—C(S)—O—, —O—C(S)—NR k —, —NR k —C(S)—O—, —NH—C(NH)—NH—, —NR k —C(NH)—NH—, —NR k —C(NR)—NH—, —NH—C(N(CN))—NH—, —NH—C(NSO 2 R c )—NH—, —NR k —C(NSO 2 R c )—NH—, —NH—C(NNO 2 )—NH—, —NH—C(NC(O)R c )—NH—,—NH—C(O)—NH—, —NR k —C(O)—NR k —, —NH—C(S)—NH— and —NR k —C(S)—NR k —, —NH—S(O) 2 —NH—, —NR k —S(O) 2 —NR k —, —NR k —S(O) 2 —O—, —P(O)(R c )—, —P(O)(R c )—O—, —P(O)(R c )—NR k —, -Cyclyl-, -Heterocyclyl-, -Aryl-, -Heteroaryl-, -Heteroarylalkyl-, -Heteroaryl-NH—, -Heteroaryl-S-, -Heteroarylalkyl-O—, —C(N—CN)—NH—, —Si(OH) 2 —, —B(OH)—, —C(NH)—NR k —, —NR k —CH 2 —C(O)—, —C(O)—ONR k —, —C(O)—NR k O—, —C(S)—ONR k —, —C(S)—NR k O—, —C(NR)—ONR k —, —C(NR)—NR k O—, —OS(O) 2 —NR k NR k —, —OC(O)—NR k NR k —, —OC(S)—NR k NR k —, —OC(NR)—NR k NR k —, —NR k NR k S(O) 2 O—, —NR k NR k C(S)O—, —NR k NR k C(NR)O—, —OP(O)(R c )O—, —NR k P(O)(R c )O—, —OP(O)(R c )N(R k )—, —NR k P(O)(R c )N(R k )—, —P(O)(R c )O—, —P(O)(R c )NR k —, —NR k P(O)(R c )—, —OP(O)(R c )—, —O-alkyl-heterocyclyl-N(R c )—, —NR k CHR g C(O)NR k CHR g C(O)—, —NR g CHR g C(O)—, —NR k C(O)CHR g —, —C(O)NR k CHR g C(O)—, or absent.

13. The compound of claim 6 , wherein G is absent.

14. A compound selected from the group consisting of:

(1) Diisopropyl-{4-methoxy-6-[N′-(1-methyl-1H-indol-3-ylmethylene)-hydrazino]-[1,3,5]triazin-2-yl}-amine;

(2) {4-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-6-methoxy-[1,3,5]triazin-2-yl}-diisopropyl-amine;

(3) Diisopropyl-{4-methoxy-6-[N′-(7-methyl-1H-indol-3-ylmethylene)-hydrazino]-[1,3,5]triazin-2-yl}-amine;

(4) {4[N′-(5-Fluoro-1H-indol-3-ylmethylene)-hydrazino]-6-methoxy-[1,3,5]triazin-2-yl}-diisopropyl-amine;

(5) 1-{3-[(4-Diisopropylamino-6-methoxy-[1,3,5]triazin-2-yl)-hydrazonomethyl]-indol -1-yl}-ethanone;

(6) [4-[N′-(1H-Indol)-3-ylmethylene)-hydrazino]-6-(2-pyridin-2-yl-ethoxy)-[1,3,5]triazin-2-ylamino]-acetic acid methyl ester;

(7) N-{4-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-thiazolidin-3-yl[1,3,5]triazin-2-yl}-N′-(1H-indol-3-ylmethylene)-hydrazine;

(8) N-[4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-6-(2-pyridin-2-yl-ethoxy)-[1,3,5]triazin-2-yl]-N′-(1H-indol-3-ylmethylene)-hydrazine;

(9) [4-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-6-(2-pyridin-2-yl-ethoxy)-[1,3,5]triazin-2-ylamino]-acetonitrile;

(10) N-(1H-Indol-3-ylmethylene)-N′-[4-(2-pyridin-2-yl-ethoxy)-6-(tetrahydro-pyran-4-yloxy)-[1,3,5]triazin-2-yl]-hydrazine;

(11) 1-[4-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-6-(2-pyridin-2-yl-ethoxy)-[1,3,5]triazin-2-yl]-piperidin-4-one;

(12) N-(3-Methyl-benzylidene)-N′-[6-piperidin-1-yl-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-hydrazine;

(13) Bis-(2-methoxy-ethyl)-[6-[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-amine;

(14) [2-(3,4-Dimethoxy-phenyl)-ethyl]-{4-methyl-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yl}-amine;

(15) {2-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-dimethyl-amine;

(16) {6-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-2-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-dimethyl-amine;

(17) [2-(3,4-Dimethoxy-phenyl)-ethyl]-{4-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yl}-amine;

(18) Dimethyl-[2-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-amine;

(19) 2,6-Bis-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-ylamine;

(20) N-{4-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-thiophen-3-yl-[1,3,5]triazin-2-yl}-N′-isopropylidene-hydrazine;

(21) N-{4-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-imidazol-1-yl-[1,3,5]triazin-2-yl}-N′-(3-methyl-benzylidene)-hydrazine;

(22) N-{4-Chloro-6-[2-(3,4-dimethoxy-phenyl)-ethoxy]-[1,3,5]triazin-2-yl}-N′-(3-methyl-benzylidene)-hydrazine;

(23) N-{4-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-phenyl-[1,3,5]triazin-2-yl}-N′-(3-methyl-benzylidene)-hydrazine;

(24) N-{4-[2-(3,4-Dimethoxy-phenyl)-ethoxy]-6-thiophen-3-yl-[1,3,5]triazin-2-yl}-N′-(3-methyl-benzylidene)-hydrazine;

(25) N-(3-Methyl-benzylidene)-N′-[2-(2-pyridin-2-yl-ethoxy)-6-pyrrolidin-1-yl-pyrimidin-4-yl]-hydrazine;

(26) N-[6-Azetidin-1-yl-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-N′-(3-methyl-benzylidene)-hydrazine;

(27) 3-{6-Dimethylamino-2-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-propan-1-ol;

(28) (4-Nitro-phenyl)-carbamic acid 3-{6-dimethylamino-2-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-propyl ester;

(29) (4-Trifluoromethyl-phenyl)-carbamic acid 3-{6-dimethylamino-2-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-propyl ester;

(30) Diethyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-amine;

(31) (2-Methoxy-ethyl)-methyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-amine;

(32) 6-(2,3-Dimethyl-1H-indol-5-ylamino)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid methyl ester;

(33) 6-(2,3-Dimethyl-1H-indol-5-ylamino)-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid dimethylamide;

(34) [6-(2,3-Dimethyl-1H-indol-5-ylamino)-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-morpholin-4-yl-methanone;

(35) 4-(2,3-Dimethyl-1H-indol-5-ylamino)-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-2-carboxylic acid methyl ester;

(36) N-(1H-Indol-3-ylmethylene)-N′-[2-(2-pyridin-2-yl-ethoxy)-6-thiazolidin-3-yl-pyrimidin-4-yl]-hydrazine;

(37) N-(1H-Indol-3-ylmethylene)-N′-[2-(2-morpholin-4-yl-ethoxy)-6-thiazolidin-3-yl-pyrimidin-4-yl]-hydrazine;

(38) N-(3-Methyl-benzylidene)-N′-[2-(2-morpholin-4-yl-ethoxy)-6-thiazolidin-3-yl-pyrimidin-4-yl]-hydrazine;

(39) 3-(2-{4-[N′-(3-Methyl-benzylidene)-hydrazino]-6-thiazolidin-3-yl-pyrimidin-2-yloxy}-ethyl)-oxazolidin-2-one;

(40) 4-Methyl-2-{[2-(2-methylamino-ethoxy)-6-thiazolidin-3-yl-pyrimidin-4-yl]-hydrazonomethyl}-phenol;

(41) N-(3-Methyl-benzylidene)-N′-[6-(2-morpholin-4-yl-ethoxy)-4-thiazolidin-3-yl-pyridin-2-yl]-hydrazine;

(42) N-(3-Methyl-benzylidene)-N′-[2-(2-morpholin-4-yl-ethoxy)-6-thiazolidin-3-yl-pyridin-4-yl]-hydrazine;

(43) (2,3-Dimethyl-1H-indol-6-yl)-[2-(2-morpholin-4-yl-ethoxy)-6-thiazolidin-3-yl-pyrimidin-4-yl]-amine;

(44) 2-(2-Morpholin-4-yl-ethoxy)-6-thiazolidin-3-yl-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(45) 3-(2-{4-Diethylamino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-ethyl)-oxazolidin-2-one;

(46) Diethyl-{2-(2-methylamino-ethoxy)-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-amine;

(47) 1-{4-Diethylamino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-2-methyl-propan-2-ol;

(48) Diethyl-[6[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-amine;

(49) 2-{[6-Diethylamino-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazonomethyl}-4-methyl-phenol;

(50) Diethyl-[6-[N′-(1H-indol-3-ylmethylene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-amine;

(51) Diethyl-[4-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazin-2-yl]-amine;

(52) Diethyl-[2-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-amine;

(53) Diethyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-4-(2-morpholin-4-yl-ethoxy)-pyridin-2-yl]-amine;

(54) 6-Diethylamino-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-imethyl-1H-indol-5-yl)-amide;

(55) 6-Diethylamino-2-(2-morpholin-4-yl-ethoxy)-4-[(2,3-dimethy-1H-indol-5-yl)-amino]-pyrimidine;

(56) 3-(2-{4-[(2-Methoxy-ethyl)-methyl-amino]-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxyl}-ethyl)-oxazolidin-2-one;

(57) (2-Methoxy-ethyl)-methyl-{2-(2-methylamino-ethoxy)-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-amine;

(58) 1-{4-[(2-Methoxy-ethyl)-methyl-amino]-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-2-methyl-propan-2-ol;

(59) (2-Methoxy-ethyl)-methyl-[4-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazin-2-yl]-amine;

(60) (2-Methoxy-ethyl)-methyl-[2-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-pyridin-4-yl]-amine;

(61) (2-Methoxy-ethyl)-methyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-4-(2-morpholin-4-yl-ethoxy)-pyridin-2-yl]-amine;

(62) 2-{[6-[(2-Methoxy-ethyl)-methyl-amino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazonomethyl}-4-methyl-phenol;

(63) [6-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-(2-methoxy-ethyl)-methyl-amine;

(64) 4-[(2-Methoxy-ethyl)-methyl-amino]-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazine-2-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(65) N-(2,3-Dimethyl-1H-indol-5-yl)-N′-(2-methoxy-ethyl)-N′-methyl-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazine-2,4-diamine;

(66) Dimethyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-amine;

(67) 3-(2-{4-Dimethylamino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-ethyl)-oxazolidin-2-one;

(68) Dimethyl-{2-(2-methylamino-ethoxy)-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-yl}-amine;

(69) 1-{4-Dimethylamino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-2-methyl-propan-2-ol;

(70) Dimethyl-[6[N′-(3-methyl-benzylidene)-hydrazino]-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-amine;

(71) 2-{[6-Dimethylamino-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazonomethyl}-4-methyl-phenol;

(72) [6-[N′-(2-Amino-5-methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-dimethyl-amine;

(73) [6-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-dimethyl-amine;

(74) Dimethyl-[4-[N′-(3-methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazin-2-yl]-amine;

(75) Dimethyl-[6-[N′-(3-methyl-benzylidene)-hydrazino]-4-(2-morpholin-4-yl-ethoxy)-pyridin-2-yl]-amine;

(76) 6-Dimethylamino-2-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(77) 6-Dimethylamino-2-(2-morpholin-4-yl-ethoxy)-4-[(2,3-dimethyl-1H-indol-5-yl)-amino] pyrimidine;

(78) 6-[N′-(3-Methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-ylamine;

(79) 3-(2-{4-Amino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-ethyl)-oxazolidin-2-one;

(80) 2-(2-Methylamino-ethoxy)-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-4-ylamine;

(81) 6-[N′-(3-Methyl-benzylidene)-hydrazino]-2-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-ylamine;

(82) 2-{[6-Amino-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazonomethyl}-4-methyl-phenol;

(83) 6-[N′-(2-Amino-5-methyl-benzylidene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-ylamine;

(84) 6-[N′-(1H-Indol-3-ylmethylene)-hydrazino]-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-ylamine;

(85) 1-{4-Amino-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-2-methyl-propan-2-ol;

(86) 2-[N′-(3-Methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-pyridin-4-ylamine;

(87) 6-[N′-(3-Methyl-benzylidene)-hydrazino]-4-(2-morpholin-4-yl-ethoxy)-pyridin-2-ylamine;

(88) 4-[N′-(3-Methyl-benzylidene)-hydrazino]-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazin-2-ylamine;

(89) 2-Amino-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(90) N4-(2,3-Dimethyl-1H-indol-5-yl)-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-2,4-diamine;

(91) N-[4-Imidazol-1-yl-6-(2-morpholin-4-yl-ethoxy)-[1,3,5]triazin-2-yl]-N′-(3-methyl-benzylidene)-hydrazine;

(92) 3-(2-{4-Imidazol-1-yl-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-ethyl)-oxazolidin-2-one;

(93) (2-{4-Imidazol-1-yl-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-ethyl)-methyl-amine;

(94) 1-{4-Imidazol-1-yl-6-[N′-(3-methyl-benzylidene)-hydrazino]-pyrimidin-2-yloxy}-2-methyl-propan-2-ol;

(95) N-[4-Imidazol-1-yl-6-(2-morpholin-4-yl-ethoxy)-pyridin-2-yl]-N′-(3-methyl-benzylidene)-hydrazine;

(96) 2-{[6-Imidazol-1-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazonomethyl}-4-methyl-phenol;

(97) N-[6-Imidazol-1-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-N′-(1H-indol-3-ylmethylene)-hydrazine;

(98) 2-Imidazol-1-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(99) (2,3-Dimethyl-1H-indol-5-yl)-[2-imidazol-1-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-amine;

(100) 1-[2,4′]Bipyridinyl-6-yl-3-indan-5-yl-urea;

(101) 4-(2-Morpholin-4-yl-ethoxy)-[2,4′]bipyridinyl-6-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(102) 4-[(2-Methoxy-ethyl)-methyl-amino]-[2,4′]bipyridinyl-6-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(103) 3′-Fluoro-[2,4′]bipyridinyl-6-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(104) 6-Pyrimidin-5-yl-pyridine-2-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(105) 6-Thiophen-3-yl-pyridine-2-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(106) [2,3′]Bipyridinyl-6-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(107) 2′-Fluoro-[2,4′]bipyridinyl-6-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(108) 6-(1H-Pyrazol-4-yl)-pyridine-2-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide;

(109) (E)-4-(2-(4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yloxy)ethyl)morpholine;

(110) (E)-4-methyl-2-((2-(2-(2-morpholinoethoxy)-6-(pyridin-4-yl)pyrimidin-4-yl)hydrazono)methyl)phenol;

(111) (E)-4-(2-(4-(2-(3,4-dimethylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yloxy)ethyl)morpholine;

(112) (E)-4-(2-(4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yloxy)ethyl)morpholine;

(113) (E)-N-(2-methoxyethyl)-N-methyl-4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-amine;

(114) (E)-2-((2-(2-((2-methoxyethyl)(methyl)amino)-6-(pyridin-4-yl)pyrimidin-4-yl)hydrazono)methyl)-4-methylphenol;

(115) (E)-4-(2-(3,4-dimethylbenzylidene)hydrazinyl)-N-(2-methoxyethyl)-N-methyl-6-(pyridin-4-yl)pyrimidin-2-amine;

(116) (E)-4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-N-(2-methoxyethyl)-N-methyl-6-(pyridin-4-yl)pyrimidin-2-amine;

(117) (E)-2-(methyl(4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)amino)ethanol;

(118) (E)-2-((4-(2-(3,4-dimethylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)(methyl)amino)ethanol;

(119) (E)-2-((2-(2-((2-hydroxyethyl)(methyl)amino)-6-(pyridin-4-yl)pyrimidin-4-yl)hydrazono)methyl)-4-methylphenol;

(120) (E)-2-((4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)(methyl)amino)ethanol;

(121) (E)-O-methyl-N-(4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)hydroxylamine;

(122) (E)-N-(4-(2-(3,4-dimethylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)-O-methylhydroxylamine;

(123) (E)-2-((2-(2-(methoxyamino)-6-(pyridin-4-yl)pyrimidin-4-yl)hydrazono) methyl)-4-methylphenol;

(124) (E)-N-(4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-6-(pyridin-4-yl)pyrimidin-2-yl)-O-methylhydroxylamine;

(125) (E)-4-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)-6-(pyridin-4-yl)pyrimidine;

(126) (E)-4-(2-(3,4-dimethylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)-6-(pyridin-4-yl)pyrimidine;

(127) (E)-4-methyl-2-((2-(2-(2-(pyridin-2-yl)ethoxy)-6-(pyridin-4-yl)pyrimidin-4-yl)hydrazono)methyl)phenol;

(128) (E)-4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)-6-(pyridin-4-yl)pyrimidine;

(129) (E)-4-(2-(4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)-1,3,5-triazin-2-yloxy)ethyl)morpholine;

(130) (E)-4-(2-(4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-6-(pyridin-4-yl)-1,3,5-triazin-2-yloxy)ethyl)morpholine;

(131) (E)-N-(2-methoxyethyl)-N-methyl-4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)-1,3,5-triazin-2-amine;

(132) (E)-4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-N-(2-methoxyethyl)-N-methyl-6-(pyridin-4-yl)-1,3,5-triazin-2-amine;

(133) (E)-O-methyl-N-(4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-4-yl)-1,3,5-triazin-2-yl)hydroxylamine;

(134) (E)-N-(4-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-6-(pyridin-4-yl)-1,3,5-triazin-2-yl)-O-methylhydroxylamine;

(135) (E)-4-(2-(6-(2-(3-methylbenzylidene)hydrazinyl)-4,4′-bipyridin-2-yloxy)ethyl)morpholine;

(136) (E)-4-(2-(6-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-4,4′-bipyridin-2-yloxy)ethyl)morpholine;

(137) (E)-2-(methyl(6-(2-(3-methylbenzylidene)hydrazinyl)-4,4′-bipyridin-2-yl)amino)ethanol;

(138) (E)-2-((6-(2-(3,4-dimethylbenzylidene)hydrazinyl)-4,4′-bipyridin-2-yl)(methyl)amino)ethanol;

(139) (E)-6-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-N-(2-methoxyethyl)-N-methyl-4,4′-bipyridin-2-amine;

(140) (E)-6-(2-((4,5-dimethylthiophen-2-yl)methylene)hydrazinyl)-N-(2-methoxyethyl)-N-methyl-4,4′-bipyridin-2-amine;

(141) (E)-4-(2-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrimidin-4-yloxy)ethyl)morpholine;

(142) (E)-4-(methoxymethyl)-6-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrimidine;

(143) (E)-4-(2-(3-methylbenzylidene)hydrazinyl)-6-(pyridin-3-yl)-1,3,5-triazin-2-amine;

(144) 1-(4-(methylthio)-6-(pyridin-4-yl)-1,3,5-triazin-2-yl)-3-m-tolylurea;

(145) 1-(4-(methylthio)-6-(pyridin-3-yl)-1,3,5-triazin-2-yl)-3-m-tolylurea;

(146) N-(2,3-dimethyl-1H-indol-5-yl)-2,4′-bipyridine-6-carboxamide;

(147) N-(2,3-dimethyl-1H-indol-5-yl)-2-(dimethylamino)-6-(2-morpholino ethylamino) pyrimidine-4-carboxamide; and

(148) N-(2,3-dimethyl-1H-indol-5-yl)-6-(2-morpholinoethylamino)-2-(thiazolidin-3-yl)pyrimidine-4-carboxamide;

or pharmaceutically acceptable salts thereof.

15. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of claim 1 .