IL-12 modulatory compounds

1. A compound of formula (I):

or a pharmaceutically acceptable salt thereof,

wherein:

X is represented by a formula selected from the group consisting of:

R 1 is R′-L′-R″;

R′ is absent;

L′ is absent; and

R″ is H, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, N(R k )(CH 2 ) n R g , —OR k , —SR k , —NR h R j , hydroxylalkyl, —C(O)R c , —C(S)R c , —C(NR)R c , halo, haloalkyl, aminoalkyl, mercaptoalkyl, cyano, nitro, —S(O)R c , —S(O) 2 R c , —P(O)R c R c , —P(S)R c R c or an optionally substituted alkylcarbonylalkyl;

Q is CR g , V and U are N;

R 3 is R g , —C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(O)R c , —C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(S)R c , —C(NR)R c , —OC(NR)R c , —SC(NR)R c , —NR k C(NR)R c , —S(O) 2 R c , —S(O)R c , —NR k S(O) 2 R c , —OS(O) 2 R c , —OP(O)R c R c , or —P(O)R c R c ;

R 2 and R 4 are, independently, H, an optionally substituted alkyl, an optionally substituted alkylcarbonyl, —OR k , —SR k , —NR h R j , hydroxylalkyl, —C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(O)R c , —C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(S)R c , —C(NR)R c , —OC(NR)R c , —SC(NR)R c , —NR k C(NR)R c , —SO 2 R c , —S(O)R c , —NR k SO 2 R c , —OS(O) 2 R c , —OP(O)R c R c , —P(O)R c R c , halo, haloalkyl, aminoalkyl, mercaptoalkyl, cyano, nitro, nitroso, azide, an optionally substituted alkylcarbonylalkyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted heteroaryl, an optionally substituted heteroaralkyl, or isothionitro; or R 2 and R 4 taken together are ═O, ═S, or ═NR;

R c , for each occurrence, is independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl, haloalkyl, —OR k , —SR k , —NR h R j , hydroxylalkyl, alkylcarbonylalkyl, mercaptoalkyl, aminoalkyl, sulfonylalkyl, sulfonylaryl, or thioalkoxy;

R d and R e , together with the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, and an optionally substituted heteroaryl;

R g , for each occurrence, is independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl, haloalkyl, —OR k , —SR k , —NR h R j , hydroxylalkyl, alkylcarbonylalkyl, mercaptoalkyl, aminoalkyl, sulfonylalkyl, sulfonylaryl, thioalkoxy, —C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(O)R c , —C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(S)R c , —C(NR)R c , —OC(NR)R c , —SC(NR)R c , —NR k C(NR)R c , —S(O) 2 R c , —S(O)R c , —NR k S(O) 2 R c , —OS(O) 2 R c , —OP(O)R c R c , —P(O)R c R c , halo, aminoalkyl, mercaptoalkyl, cyano, nitro, nitroso, or azide;

R h and R j , for each occurrence, are independently H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, an optionally substituted heteroaryl; or R h and R j taken together with the N to which they are attached is an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, or an optionally substituted heteroaryl;

R k , for each occurrence, is independently H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cyclyl, an optionally substituted cycloalkyl, an optionally substituted heterocyclyl, an optionally substituted heterocycloalkyl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, an optionally substituted aryl, or an optionally substituted heteroaryl;

G is absent;

Y is O, CH 2 or;

m is 0, 1, 2, 3, or 4;

n is 0, 1, 2, 3, or 4;

p is 0, 1 or 2;

Z is N; and

W is O.

2. The compound of claim 1 , wherein X is represented by the following formula:

3. The compound of claim 1 , wherein X is represented by the following formula:

4. The compound of claim 1 , wherein X is represented by the following formula:

5. The compound of claim 1 , wherein R 3 is R g .

6. The compound of claim 5 , wherein R 3 is H.

7. The compound of claim 5 , wherein R 3 is an optionally substituted aryl or an optionally substituted heteroaryl.

8. The compound of claim 7 , wherein R 3 is an optionally substituted phenyl, an optionally substituted naphthyl, an optionally substituted anthracenyl, an optionally substituted fluorenyl, an optionally substituted indenyl, an optionally substituted azulenyl, an optionally substituted pyridyl, an optionally substituted 1-oxo-pyridyl, an optionally substituted furanyl, an optionally substituted benzo[1,3]dioxolyl, an optionally substituted benzo[1,4]dioxinyl, an optionally substituted thienyl, an optionally substituted pyrrolyl, an optionally substituted oxazolyl, an optionally substituted imidazolyl, an optionally substituted thiazolyl, an optionally substituted isoxazolyl, an optionally substituted quinolinyl, an optionally substituted pyrazolyl, an optionally substituted isothiazolyl, an optionally substituted pyridazinyl, an optionally substituted pyrimidinyl, an optionally substituted pyrazinyl, an optionally substituted triazinyl, an optionally substituted triazolyl, an optionally substituted thiadiazolyl, an optionally substituted isoquinolinyl, an optionally substituted indazolyl, an optionally substituted benzoxazolyl, an optionally substituted benzofuryl, an optionally substituted indolizinyl, an optionally substituted imidazopyridyl, an optionally substituted tetrazolyl, an optionally substituted benzimidazolyl, an optionally substituted benzothiazolyl, an optionally substituted benzothiadiazolyl, an optionally substituted benzoxadiazolyl, an optionally substituted indolyl, an optionally substituted tetrahydroindolyl, an optionally substituted azaindolyl, an optionally substituted indazolyl, an optionally substituted imidazopyridyl, an optionally substituted quinazolinyl, an optionally substituted purinyl, an optionally substituted pyrrolo[2,3]pyrimidinyl, an optionally substituted pyrazolo[3,4]pyrimidinyl, or an optionally substituted benzo(b)thienyl.

9. The compound of claim 5 , wherein R 3 is an optionally substituted heterocyclyl or an optionally substituted heteroalkyl.

10. The compound of claim 1 , wherein each of R 2 and R 4 is, independently, H, an optionally substituted alkyl, an optionally substituted alkylcarbonyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, or an optionally substituted heterocyclyl.

11. The compound of claim 10 , wherein each of R 2 and R 4 is H or a lower alkyl.

12. The compound of claim 1 , wherein R″ is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, nitro, cyano, halo, OR k , SR k , or NR h R j .

13. The compound of claim 12 , wherein R″ is an optionally substituted aryl or an optionally substituted heteroaryl.

14. The compound of claim 13 , wherein R″ is an optionally substituted phenyl, an optionally substituted naphthyl, an optionally substituted anthracenyl, an optionally substituted fluorenyl, an optionally substituted indenyl, an optionally substituted azulenyl, an optionally substituted pyridyl, an optionally substituted 1-oxo-pyridyl, an optionally substituted furanyl, an optionally substituted benzo[1,3]dioxolyl, an optionally substituted benzo[1,4]dioxinyl, an optionally substituted thienyl, an optionally substituted pyrrolyl, an optionally substituted oxazolyl, an optionally substituted imidazolyl, an optionally substituted thiazolyl, an optionally substituted isoxazolyl, an optionally substituted quinolinyl, an optionally substituted pyrazolyl, an optionally substituted isothiazolyl, an optionally substituted pyridazinyl, an optionally substituted pyrimidinyl, an optionally substituted pyrazinyl, an optionally substituted triazinyl, an optionally substituted triazolyl, an optionally substituted thiadiazolyl, an optionally substituted isoquinolinyl, an optionally substituted indazolyl, an optionally substituted benzoxazolyl, an optionally substituted benzofuryl, an optionally substituted indolizinyl, an optionally substituted imidazopyridyl, an optionally substituted tetrazolyl, an optionally substituted benzimidazolyl, an optionally substituted benzothiazolyl, an optionally substituted benzothiadiazolyl, an optionally substituted benzoxadiazolyl, an optionally substituted indolyl, an optionally substituted tetrahydroindolyl, an optionally substituted azaindolyl, an optionally substituted indazolyl, an optionally substituted imidazopyridyl, an optionally substituted quinazolinyl, an optionally substituted purinyl, an optionally substituted pyrrolo[2,3]pyrimidinyl, an optionally substituted pyrazolo[3,4]pyrimidinyl, or an optionally substituted benzo(b)thienyl.

15. The compound of claim 12 , wherein R″ is a group represented by the following formula:

wherein:

the dashed line indicates a double or a single bond;

X 1 is —O—, —S(O) p —, —N(R k )—, or —C(R g )(R g )—;

R 6 and R 7 are each, independently, R g , —C(O)R c , —C(S)R c , —C(NR)R c , —NR k C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(NR)R c , —OC(NR)R c , or —SC(NR)R c ; or R 6 and R 7 , taken together with the carbons to which they are attached, form a 5- to 7-membered optionally substituted cycloalkyl, a 5- to 7-membered optionally substituted cyclyl, a 5- to 7-membered optionally substituted aryl, a 5- to 7-membered optionally substituted heterocycloalkyl, a 5- to 7-membered optionally substituted heterocyclyl, a 5- to 7-membered optionally substituted heteroaryl;

R 8 , for each occurrence, is, independently, R g , —C(O)R c , —C(S)R c , —C(NR)R c , —NR k C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(NR)R c , —OC(NR)R c , or —SC(NR)R c ; and

t is 0, 1, 2, or, 3.

16. The compound of claim 15 , wherein R″ is (2,3-dimethyl-1H-indol-5-yl), (1H-indol-5-yl), or (6,7,8,9-tetrahydro-5H-carbazol-3-yl).

17. The compound of claim 12 , wherein R″ is a group represented by the following formula:

wherein:

R 10 and R 11 , for each occurrence, are, independently, R g , —C(O)R c , —C(S)R c , —C(NR)R c , —NR k C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(S)R c , —OC(S)Rc, —SC(S)R c , —NR k C(NR)R c , —OC(NR)R c , or —SC(NR)R c ; and

s is 0, 1, 2, 3, or 4.

18. The compound of claim 17 , wherein R″ is a group represented by the following formula:

19. The compound of claim 12 , wherein R″ is a group represented by the following structural formula:

wherein;

X 2 is —O—, —S(O) p —, or —NR k —;

R 11 , for each occurrence, is independently, R g , —C(O)R c , —C(S)R c , —C(NR)R c , —NR k C(O)R c , —OC(O)R c , —SC(O)R c , —NR k C(S)R c , —OC(S)R c , —SC(S)R c , —NR k C(NR)R c , —OC(NR)R c , or —SC(NR)R c ; and

t is 0, 1, 2, or 3.

20. The compound of claim 1 , wherein R 3 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, an optionally substituted cyclyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocyclyl, nitro, cyano, halo, OR k , SR k , or NR h R j .

21. The compound of claim 20 , wherein R 3 is optionally substituted aryl or optionally substituted heteroaryl.

22. The compound of claim 21 , wherein R 3 is an optionally substituted phenyl, an optionally substituted naphthyl, an optionally substituted anthracenyl, an optionally substituted fluorenyl, an optionally substituted indenyl, an optionally substituted azulenyl, an optionally substituted pyridyl, an optionally substituted 1-oxo-pyridyl, an optionally substituted furanyl, an optionally substituted benzo[1,3]dioxolyl, an optionally substituted benzo[1,4]dioxinyl, an optionally substituted thienyl, an optionally substituted pyrrolyl, an optionally substituted oxazolyl, an optionally substituted imidazolyl, an optionally substituted thiazolyl, an optionally substituted isoxazolyl, an optionally substituted quinolinyl, an optionally substituted pyrazolyl, an optionally substituted isothiazolyl, an optionally substituted pyridazinyl, an optionally substituted pyrimidinyl, an optionally substituted pyrazinyl, an optionally substituted triazinyl, an optionally substituted triazolyl, an optionally substituted thiadiazolyl, an optionally substituted isoquinolinyl, an optionally substituted indazolyl, an optionally substituted benzoxazolyl, an optionally substituted benzofuryl, an optionally substituted indolizinyl, an optionally substituted imidazopyridyl, an optionally substituted tetrazolyl, an optionally substituted benzimidazolyl, an optionally substituted benzothiazolyl, an optionally substituted benzothiadiazolyl, an optionally substituted benzoxadiazolyl, an optionally substituted indolyl, an optionally substituted tetrahydroindolyl, an optionally substituted azaindolyl, an optionally substituted indazolyl, an optionally substituted imidazopyridyl, an optionally substituted quinazolinyl, an optionally substituted purinyl, an optionally substituted pyrrolo[2,3]pyrimidinyl, an optionally substituted pyrazolo[3,4]pyrimidinyl, or an optionally substituted benzo(b)thienyl.

23. The compound of claim 20 , wherein R 3 is an optionally substituted heterocycloalkyl.

24. The compound of claim 23 , wherein R 3 is an optionally substituted piperidinyl, an optionally substituted piperazinyl, an optionally substituted 2-oxopiperazinyl, an optionally substituted 2-oxopiperidinyl, an optionally substituted 2-oxopyrrolidinyl, an optionally substituted 4-piperidonyl, an optionally substituted tetrahydropyranyl, an optionally substituted oxazolidinyl, an optionally substituted 2-oxo-oxazolidinyl, an optionally substituted tetrahydrothiopyranyl, an optionally substituted tetrahydrothiopyranyl sulfone, an optionally substituted morpholinyl, an optionally substituted thiomorpholinyl, an optionally substituted thiomorpholinyl sulfoxide, an optionally substituted thiomorpholinyl sulfone, an optionally substituted 1,3-dioxolanyl, an optionally substituted [1,4]dioxanyl, an optionally substituted 2-oxo-imidazolidinyl, tetrahydrofuranyl, or an optionally substituted tetrahydrothienyl.

25. The compound of claim 1 , wherein R 3 is OR k , SR k , C(O)OR k , NR h R j , or C(O)NR h R j .

26. The compound of claim 25 , wherein R 3 is —OR k , —C(O)R c , —OC(O)R c , —NR k C(O)R c or —NR h R j , and R k , R h and R j are each, independently, H, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl, or an optionally substituted heterocycloalkyl.

27. A compound selected from the group consisting of: 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, [6-(2,3-Dimethyl-1H-indol-5-ylcarbamoyl)-2-morpholin-4-yl-pyrimidin-4-yloxy]-acetic acid ethyl ester, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid m-tolylamide, 6-(2-Hydroxy-2-methyl-propoxy)-2-morpholin-4-yl-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (6,7,8,9-tetrahydro-5H-carbazol-3-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (5-furan-2-yl-1H-pyrazol-3-yl)-amide, 1-[2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-3-m-tolyl-urea, 1-[6-(2-Methylamino-ethoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-3-m-tolyl-urea, 1-[6-(2-Hydroxy-2-methyl-propoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-3-m-tolyl-urea, 1-[2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-3-phenyl-urea, 1-[2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-3-p-tolyl-urea, 1-(3-Methoxy-phenyl)-3-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-urea, 1-(4-Chloro-phenyl)-3-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-urea, 1-(2-Methoxy-phenyl)-3-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-urea, 1-Benzyl-3-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-urea, [6-(2.3-Dimethyl-1H-indol-5-ylcarbamoyl)-2-morpholin-4-yl-pyrimidin-4-yloxy]-acetic acid ethyl ester, 2-Morpholin-4-yl-6-[2-(2-oxo-oxazolidin-3-yl)-ethoxy]-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3,4-dimethyl-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (1,2,3-trimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-carbamoyl-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-dimethylamino-phenyl)-amide, 2-Morpholin-4-yl-6-[2-(4-oxy-morpholin-4-yl)-ethoxy]-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 6-Methoxy-2-morpholin-4-yl-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid methyl-(1,2,3-trimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (6-methyl-benzothiazol-2-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (9-ethyl-9H-carbazol-2-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (6-methyl-pyridin-2-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (4-methyl-pyridin-2-yl)-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid benzothiazol-6-ylamide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid naphthalen-2-ylamide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid quinolin-6-ylamide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid quinolin-5-ylamide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid indan-5-ylamide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-7-yl)-amide, 2-Morpholin-4-yl-6-(2-piperidin-1-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 2-Morpholin-4-yl-6-[2-(2-oxo-oxazolidin-3-yl)-ethoxy]-pyrimidine-4-carboxylic acid (3-carbamoyl-phenyl)-amide, 2-Morpholin-4-yl-6-[2-(2-oxo-oxazolidin-3-yl)-ethoxy]-pyrimidine-4-carboxylic acid m-tolylamide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (5-thiophen-2-yl-1H-pyrazol-3-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-ethyl-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-bromo-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (5-methyl-isoxazol-3-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2-acetylamino-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-sulfamoyl-phenyl)-amide, 2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid (3,4-dimethyl-phenyl)-amide, 2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid (3-carbamoyl-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-dimethylcarbamoyl-phenyl)-amide, Indol-1-yl-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-methanone, (3,4-Dihydro-1H-isoquinolin-2-yl)-[2-morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-methanone, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid m-tolylamide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (4-dimethylamino-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid [3-(pyrrolidine-1-carbonyl)-phenyl]-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (2-methoxy-5-methyl-phenyl)-amide, 2-Morpholin-4-yl-6-(2-morpholin-4-yl-ethoxy)-pyrimidine-4-carboxylic acid (3-hydroxy-phenyl)-amide, 6-Morpholin-4-yl-2-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (2,3-dimethyl-1H-indol-5-yl)-amide, 6-Morpholin-4-yl-2-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid (6-methyl-benzothiazol-2-yl)-amide, 1-[2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-3-m-tolyl-urea, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid 1H-indol-5-yl ester, 1H-Indole-5-carboxylic acid [2-morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-amide, 2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidine-4-carboxylic acid N′-m-tolyl-hydrazide, [2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-carbamic acid m-tolyl ester, (2,3-Dimethyl-1H-indol-5-yl)-[2-morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-ylmethyl]-amine, N-[2-Morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-N′-m-tolyl-oxalamide, and N-(3-Hydroxy-phenyl)-N′-[2-morpholin-4-yl-6-(2-pyridin-2-yl-ethoxy)-pyrimidin-4-yl]-oxalamide, or a pharmaceutically acceptable salt thereof.

28. A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.

29. A method of inhibiting IL-12 production in a subject, comprising administering to the subject an effective amount of a compound of claim 1 .

30. A method for treating an interleukin-12 overproduction-related disorder wherein the disorder is rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or immune-mediated diabetes mellitus, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 .

31. A method for inhibiting osteoclast formation in vitro or in vivo, the method comprising contacting a pre-osteoclast cell with an effective amount of a compound of claim 1 .

32. A method of inhibiting proliferation of T H 1 cells in a subject comprising administering to the subject an effective amount of a compound of claim 1 .

33. A method of inhibiting the production of IL-12 in a subject comprising administering to the subject an effective amount of a compound represented by claim 1 .

34. A method of inhibiting IL-23 production in a subject, comprising administering to the subject an effective amount of a compound of claim 1 .

35. The method of claim 34 , further comprising inhibiting the production of IL-12.

36. A method of inhibiting IL-27 production in a subject, comprising administering to the subject an effective amount of a compound of claim 1 .

37. The method of claim 36 , further comprising inhibiting T H 1 lymphocyte proliferation.

38. The method of claim 37 , further comprising inhibiting the production of IL-12.