IP Library › Granted Patent US 7,314,609
Granted Patent B2
US 7,314,609 · App. 11/274,505 · Granted Jan 1, 2008

Stereoisomers of fatty acid analogs for diagnostic imaging

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Quick Facts
Patent No.
US 7,314,609
App. No.
11/274,505
Granted
Jan 1, 2008
Kind
B2
Abstract

The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.

Claims (11)

1. A substantially pure stereoisomer of 15-(p-radiohalophenyl)-3-methylpentadecanoic acid, in which radiohalo is selected from the group consisting of radioiodo and radiofluoro.

2. The substantially pure stereoisomer of claim 1 , which is 15-(p-[ 123 I]iodophenyl)-3-(R)-methylpentadecanoic acid.

3. The substantially pure stereoisomer of claim 1 , which is 15-(p-[ 231 I]iodophenyl)-3-(S)-methylpentadecanoic acid.

4. The substantially pure stereoisomer of claim 1 , which 15-(p-[ 18 F]fluorophenyl)-3-(R)-methylpentadecanoic acid.

5. The substantially pure stereoisomer of claim 1 , which 15-(p-[ 18 F]fluorophenyl)-3-(S)-methylpentadecanoic acid.

6. A method of radio imaging cardiovascular tissue of a subject comprising administering intravenously to a subject an effective amount of a substantially pure stereoisomer of a radionuclide labeled β-methyl fatty acid analog, which is 15-(p-radiohalophenyl)-3-methylpentadecanoic acid.

7. The method of claim 6 in which said β-methyl fatty acid analog is 15-(p-[ 123 I]iodophenyl)-3-methylpentadecanoic acid.

8. The method of claim 6 in which said β-methyl fatty acid analog is 15-(p-[ 131 I]iodophenyl)-3-methylpentadecanoic acid.

9. The method of claim 6 in which said β-methyl fatty acid analog is 15-(p-[ 18 F]fluorophenyl)-3-methylpentadecanoic acid.

10. The method of claim 6 in which said β-methyl fatty acid analog has an (R)-stereoisomeric configuration.

11. The method of claim 6 in which said β-methyl fatty acid analog has an (S)-stereoisomeric configuration.

Assignments (7)
RELEASE OF PATENT SECURITY INTEREST Recorded Jan 18, 2013
From: NEXBANK, SSB (AS COLLATERAL AGENT)
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 029660/0618 →
MERGER Recorded Jun 6, 2011
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 026396/0273 →
GRANT OF SECURITY INTEREST IN PATENT RIGHTS Recorded May 26, 2011
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: NEXBANK, SSB, A TEXAS-CHARTERED SAVINGS BANK, AS COLLATERAL AGENT
Reel/Frame 026347/0233 →
TERMINATION AND RELEASE OF GRANT OF SECURITY INTEREST IN PATENT RIGHTS Recorded May 23, 2011
From: THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (F/K/A THE BANK OF NEW YORK TRUST COMPANY, N.A.)
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 026328/0309 →
SECURITY AGREEMENT Recorded Nov 19, 2007
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: BANK OF NEW YORK TRUST COMPANY, N.A., THE
Reel/Frame 020143/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 31, 2006
From: ELMALEH, DAVID R.
To: BIOSTREAM, INC.
Reel/Frame 018195/0623 →
CHANGE OF NAME Recorded Aug 31, 2006
From: BIOSTREAM, INC.
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 018196/0036 →