Compounds

1. A compound of formula I

wherein:

P is phenyl, whereby the phenyl ring is substituted on position 3 or disubstituted on positions 2 and 5;

R 1 is attached to P via a carbon atom on ring P and is selected from the group consisting of hydrogen, hydroxy, halo, nitro, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 1-6 alkyl, OC 1-6 alkyl, C 2-6 alkenyl, OC 2-6 alkenyl, C 2-6 alkynyl, OC 2-6 alkynyl, C 0-6 alkylC 3-6 cycloalkyl, OC 0-6 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, OC 0-6 alkylaryl, CHO, (CO)R 5 , O(CO)R 5 , O(CO)OR 5 , O(CN)OR 5 , C 1-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 1-6 alkyl(CO)R 5 , OC 1-6 alkyl(CO)R 5 , C 0-6 alkylCO 2 R 5 , OC 1-6 alkylCO 2 R 5 , C 0-6 alkylcyano, OC 2-6 alkylcyano, C 0-6 alkylNR 5 R 6 , OC 2-6 alkylNR 5 R 6 , C 1-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , C 0-6 alkylNR 5 (CO)R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , C 0-6 alkylSR 5 , OC 2-6 alkylSR 5 , C 0-6 alkyl(SO)R 5 , OC 2-6 alkyl(SO)R 5 , C 0-6 alkylSO 2 R 5 , OC 2-6 alkylSO 2 R 5 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 , C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNR 5 (SO 2 )R 6 , C 0-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkylNR 5 (SO 2 )NR 5 R 6 , (CO)NR 5 R 6 , O(CO)NR 5 R 6 , NR 5 OR 6 , C 0-6 alkylNR 5 (CO)OR 6 , OC 2-6 alkylNR 5 (CO)OR 6 , SO 3 R 5 and a 5- or 6-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;

M 1 is a bond;

X 1 is C;

X 2 is selected from the group consisting of N, and O;

X 3 is selected from the group consisting of N, and O;

where the ring containing X 1 , X 2 and X 3 forms an, isoxazole, chloro-isoxazole or a methyl-isoxazole;

R is selected from the group consisting of hydrogen, C 0-3 alkyl, halo, C 0-3 alkylOR 5 , C 0-3 alkylNR 5 R 6 , C 0-3 alkyl(CO)OR 5 and C 0-3 alkylaryl;

M 2 is selected from a group consisting of C 1-3 alkyl, and C 2-3 alkynyl;

R 3 is selected from a group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, oxo, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-4 alkyl, O(CO)C 1-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, OC 1-4 alkyl, C 1-4 alkylOR 5 and C 0-4 alkylNR 5 R 6 ;

X 4 is wherein the bond between M 2 and X 4 is a single bond;

Q is triazolyl, wherein any substitutable nitrogen atom in the ring is substituted with R 4 on such nitrogen atom and any suitable carbon atom is optionally substituted with R 4 ; and

R 4 is selected from the group consisting of C 0-6 alkylcyano, ═NC 1-4 alkyl, ═NOR 5 , C 1-4 alkylhalo, halo, C 1-6 alkyl, OC 1-4 alkyl, C 2-4 alkenyl, C 0-2 alkylC 3-6 cycloalkyl, C 0-6 alkylaryl, C 0-6 alkylheteroaryl, OC 0-6 alkylaryl, OC 0-6 alkylheteroaryl, NC 0-6 alkylaryl, NC 0-6 alkylheteroaryl, C 0-6 alkylOaryl, C 0-6 alkylOheteroaryl, C 0-6 akylNaryl, C 0-6 alkylNheteroaryl, OC 0-6 alkylOaryl, OC 0-6 alkylOheteroaryl, OC 0-6 alkylNaryl, OC 0-6 alkylNheteroaryl, NC 0-6 alkylOaryl, NC 0-6 alkylOheteroaryl, NC 0-6 alkylNaryl, NC 0-6 alkylNheteroaryl, O(CO)C 1-4 alkyl, C 0-4 alkyl(CO)OC 1-4 alkyl, C 1-4 alkyl(S)C 0-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, C 1-4 alkylOR 5 , C 0-4 alkylN(C 1-4 alkyl) 2 and a 3- or 6-membered non-aromatic ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5-membered ring containing one or more atoms independently selected from the group consisting of C, N and O and wherein said ring and said fused ring may be substituted by one or two A; or

ii) selected from the group consisting of tetrahydrotriazolopyridyl, tetrahydrotriazolopyrimidinyl, and pyridonyl; and

R 4 is selected from the group consisting of hydrogen, hydroxy, C 0-6 alkylcyano, ═NR 5 , ═NOR 5 , C 1-4 alkylhalo, halo, C 1-6 alkyl, OC 1-4 alkyl, OC 0-6 alkylaryl, O(CO)C 1-4 alkyl, C 0-4 alkyl(S)C 0-4 alkyl, C 1-4 alkyl(SO)C 0-4 alkyl, C 1-4 alkyl(SO 2 )C 0-4 alkyl, (SO)C 0-4 alkyl, (SO 2 )C 0-4 alkyl, C 1-4 alkylOR 5 , C 0-4 alkylNR 5 R 6 and a 5- or 6-membered ring containing one or more atoms independently selected from C, N, O and S, which ring may optionally be fused with a 5 or 6 membered ring containing one or more atoms independently selected from the group consisting of C, N and O and wherein said ring and said fused ring may be substituted by one or two A;

R 5 and R 6 are independently selected from the group consisting of hydrogen and C 1-6 alkyl;

wherein any C 1-6 alkyl defined under R 1 , R 2 and R 4 may be substituted by one or more A;

A is selected from the group consisting of hydrogen, hydroxy, halo, nitro, oxo, C 0-6 alkylcyano, C 0-4 alkylC 3-6 cycloalkyl, C 1-6 alkyl, C 1-6 alkylhalo, OC 1-6 alkylhalo, C 2-6 alkenyl, C 0-3 alkylaryl, C 0-6 alkylOR 5 , OC 2-6 alkylOR 5 , C 1-6 alkylSR 5 , OC 2-6 alkylSR 5 , (CO)R 5 , O(CO)R 5 , OC 2-6 alkylcyano, OC 1-6 alkylCO 2 R 5 , O(CO)OR 5 , OC 1-6 alkyl(CO)R 5 , C 1-6 alkyl(CO)R 5 , NR 5 OR 6 , OC 2-6 alkylNR 5 R 6 , C 0-6 alkyl(CO)NR 5 R 6 , OC 1-6 alkyl(CO)NR 5 R 6 , OC 2-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)R 6 , C 0-6 alkylNR 5 (CO)NR 5 R 6 , O(CO)NR 5 R 6 , C 0-6 alkyl(SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )NR 5 R 6 , C 0-6 alkylNR 5 (SO 2 )R 6 , OC 2-6 alkylNR 5 (SO 2 )R 6 , SO 3 R 5 , C 1-6 alkylNR 5 (SO 2 )NR 5 R 6 , OC 2-6 alkyl(SO 2 )R 5 , C 0-6 alkyl(SO 2 )R 5 , C 0-6 alkyl(SO)R 5 , OC 2-6 alkyl(SO)R 5 and a 5-membered ring containing one or more atoms independently selected from the group consisting of C, N, O and S;

m1 is selected from 0, 1, 2, 3 and 4;

m2 is selected from 0, 1, 2 and 3;

n is selected from 0, 1 and 2; and

t is 0 or 1, and a salt thereof.

2. The compound according to claim 1 , wherein P is phenyl substituted on position 3.

3. The compound according to claim 1 , wherein P is phenyl disubstituted on positions 2 and 5.

4. The compound according to claim 1 , wherein M 2 is C 1-3 alkyl and R 3 is hydrogen, methyl or dimethyl.

5. The compound according to claim 1 , wherein R 4 is selected from the group consisting of benzo[b]thiophenyl, benzodioxolyl, bromo, bromofuryl, butoxyphenyl, chloromethoxypyridyl, chlorophenyl, chlorophenylmethanol, chloropyridyl, chlorothiophene, cyanophenyl, cyclohexyl, cyclopentyl, dichloro-phenyl, dichloropyridyl, difluorophenyl, dimethylthiazolyl, ethanol, ethoxymethyl, fluoromethylphenyl, fluorophenyl, formic acid methyl ester, furyl, hydrogen, hydroxyphenoxymethyl, hydroxyphenyl, imidazolyl, methoxyethyl, methoxymethyl, methoxyphenoxymethyl, methoxyphenyl, methoxyphenylethyl, methoxypyridazinyl, methoxypyridyl, methoxypyrimidinyl, methoxythiophene, methylimidazolyl, methylpyridyl, methylsulfanylmethyl, methylthiazolyl, methylthiophene, nitrofuryl, nitrophenyl, phenyl, p-tolyloxymethyl, pyridazinyl, pyridine-oxidyl, benzylmorpholinyl, pyridinolyl, pyridyl, pyridylmethyl, pyrimidinyl, tert-butylphenyl, tetrahydrofuryl, thiazolyl, thiophene, tolyl, trifluoromethyl, acetic acid methylester, allyl, amino, benzyl, cyclopropylmethyl, ethyl, fluorobenzyl, fluoroethyl, furylmethyl, hydroxyethyl, isobutyl, methyl, methylbenzyl, methylbutyl, methylsulfanylpropyl, n-butyl, n-hexyl, n-propyl, tetrahydrofurylmethyl, thiophenylmethyl and trifluoroethyl.

6. The compound according to any one of claims 1 - 3 , 4 and 5 wherein R 1 is selected from hydrogen, methyl, ethyl, cyclopropyl, hydroxy, methoxy, cyano, fluoro, chloro, bromo, iodo, trifluoromethyl, difluoromethoxy, trifluoromethoxy, amino, nitro, dimethylamino, methylsulfanyl, vinyl, acetyl, formic acid methyl ester, methoxymethyl, ethanol and furyl.

7. The compound according to any one of claims 1 - 3 , 4 and 5 wherein m1 is 1.

8. The compound according to any one of claims 1 - 3 , 4 and 5 wherein R 3 is selected from hydrogen and C 1-4 alkyl.

9. The compound according to claim 8 wherein n is 0.

10. A compound which is selected from the group consisting of 4(5-{1-[3-(3Chloro-phenyl)-isoxazol-5-yl]ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-[5-(3-Chloro -phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-ixoxazol-3-ylmethylsulfanyl]-4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}pyridine, 4-{5-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{5-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole, 3-[3-(3-Chloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-{5-[5-(2-Fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-{4-Ethyl-5-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-4H-[1,2,4]triazol-3-yl}-pyridine, 4-Ethyl-3-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-Ethyl-3-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-ylmethylsulfanyl]-5-furan-2-yl-4H-[1,2,4]triazole, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-trifluoromethyl-4H-[1,2,4]triazole, 4-Ethyl-3-(5-thiophen-3-yl-isoxazol-3-ylmethylsulfanyl)-5-trifluoromethyl-4H-[1,2,4]triazole, 3-{1-[5-(3-Chloro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-(5-{1-[5-(3-Chloro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-Ethyl-3-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-5-furan-2-yl-4H-[1,2,4]triazole, 4-(4Ethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(3-Chloro-phenyl)-4-methyl-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-4-methyl-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-{5-[4-Chloro-5-(3-chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}pyridine, 3-[4-Chloro-5-(3-chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-Ethyl-3-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-5-thiophen-2-yl-4H-[1,2,4]triazole, 4-Methyl-3-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-5-thiophen-3-yl-4H-[1,2,4]triazole, 4-Ethyl-3-furan-2-yl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazole, 4-[4-Ethyl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-[4-Methyl-5-(5-phenyl-isoxazol-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-pyridine, 4-{5-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 3-[5-(3-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-(4-methoxy-phenyl)-4H-[1,2,4]triazole, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine, 4-{5-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-methyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]ethylsulfanyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine,4-{5-[5-(5-Chloro-2fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-cyclopropyl-4H-[1,2,4]triazol-3-yl}-pyridine, 4-(5-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-cyclopropyl-4H-[1,2,4]triazol-3-yl)-pyridine, 3-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-ylmethylsulfanyl]-4-ethyl-5-furan-2yl-4H-[1,2,4]triazole, 3-{1-[5-(5-Chloro-2-fluoro-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4-ethyl-5-furan-2-yl-4H-[1,2,4]triazole, 4-(4-Cyclopropylmethyl-5-{1-[5-(2-fluoro-5-methyl-phenyl)-isoxazol-3-yl]-ethylsulfanyl}-4H-[1,2,4]triazol-3-yl)pyridine, and 4-(5-{1-[3-(3-Chloro-phenyl)-isoxazol-5-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine or a salt thereof.

11. A pharmaceutical formulation comprising as active ingredient a therapeutically effective amount of a compound according to any one of claims 1 and 10 in association with one or more pharmaceutically acceptable diluent, excipients and/or inert carrier.