Methods for treating patients and identifying therapeutics
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient and methods for using the molecular markers in designing, screening and targeting therapeutic agents for the treatment of colon cancer.
1 . A method of identifying a candidate agent for treating colon cancer, the method comprising: identifying a candidate agent that binds to and/or inhibits an activity of a ColoUp1 polypeptide comprising a sequence that is at least 95% identical to the sequence of SEQ ID NO: 2.
2 . The method of claim 1 , further comprising testing the candidate agent for antineoplastic effects on a cell of a colon neoplasia or a cell of a cell line derived from a colon neoplasia.
3 . The method of claim 1 , further comprising testing the candidate agent for antineoplastic effects on a mouse xenograft comprising cells of a human colon cancer or cells of a cell line derived from a colon cancer cell line.
4 . The method of claim 1 , wherein the candidate agent is a siRNA probe or an antisense probe.
5 . The method of claim 1 , wherein the candidate agent is an antibody.
6 . The method of claim 1 , wherein the candidate agent is a small molecule.