IP Library Granted Patent US 7,253,181
Granted Patent B2
US 7,253,181 · App. 11/276,192 · Granted Aug 7, 2007

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Quick Facts
Patent No.
US 7,253,181
App. No.
11/276,192
Granted
Aug 7, 2007
Kind
B2
Abstract

The present invention relates to pyrrolopyridine-3-yl group containing β 3 adrenergic receptor agonists or pharmaceutical salts thereof.

Claims (19)

1. A compound of the formula:

wherein:

m is 2;

n is 0 or 1;

A 1 , A 2 and A 3 are carbon;

Het is at the ortho position relative to X and is thien-2-yl optionally substituted with CN or CH 3 ;

R 1 , R 2 and R 3 are H;

R 4 and R 5 are independently H or methyl at each occurrence;

R 6 is independently at each occurrence methyl;

R 7 is at the 6- or 7-position of the 6,5 ring system to which it is attached and is selected from H, O(CH 2 ) p R 12 or thienyl;

X is OCH 2 ;

p is 0 or 1; and

R 12 is CONH 2 , phenyl or pyridyl substituted once with CONH 2 ; or a pharmaceutical salt thereof.

2. A compound which is:

or a pharmaceutical salt thereof.

3. The compound of claim 1 which is the hydrochloride salt.

4. A pharmaceutical formulation comprising a compound of claim 1 and a pharmaceutical carrier.

5. A method of treating Type 2 Diabetes comprising administering to a patient in need thereof a compound of claim 1 .

6. A method of treating obesity comprising administering to a patient in need thereof an effective amount of a compound of claim 1 .

Assignments (3)
ASSIGNMENT OF SECURITY INTEREST IN PATENT RIGHTS, RECORDED ON AUGUST 3, 2020, AT REEL/FRAME 053388/0967 Recorded Dec 3, 2025
From: GOLDMAN SACHS BANK USA, AS RETIRING COLLATERAL AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT
Reel/Frame 073816/0021 →
SECURITY INTEREST Recorded Aug 3, 2020
From: ELANCO US INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 053388/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2018
From: ELI LILLY AND COMPANY
To: ELANCO US INC.
Reel/Frame 044696/0285 →