Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
View Patent ↗The present invention provides stereoisomers and stereoisomeric mixtures of 3-aminocarbonyl-bicycloheptene-2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
1. A compound that is (1R,2R,3S,4S)—N4-(3-aminocarbonylbicyclo [2.2.1]hept-5-ene-2-yl)-5-fluoro-N2-[3-methyl-4-(4-methylpiperazin-1-yl)]phenyl-2,4-pyrimidinediamine or a pharmaceutically acceptable salt thereof.
2. A composition comprising N4-(3-aminocarbonylbicyclo[2.2.1]hept-5-ene-2-yl)-5-fluoro-N2-[3-methyl-4-(4-methylpiperazin-1-yl)]phenyl-2,4-pyrimidinediamine or salt thereof and a pharmaceutically acceptable carrier, excipient, and/or diluent, wherein the composition is enriched in the (1R,2R,3S,4S)-diastereomer.
3. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, excipient, and/or diluent.