Process for production of 1,2,2,2-tetrafluoro ethyl difluoro methyl ether
A method for the preparation of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (CF 3 CHFOCHF 2 , Desflurane) is provided, which comprises reacting CF 3 CHClOCHF 2 (isoflurane) and hydrogen fluoride in the presence of antimony pentafluoride such that desflurane is formed.
1 . A process for the preparation of Desflurane, said process comprising forming a mixture comprising 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (CF 3 CHClOCHF 2 ), hydrogen fluoride and antimony pentafluoride, such that Desflurane is formed.
2 . A process as in claim 1 , wherein hydrogen fluoride is added in molar amounts in the range of from 0.1:1 to 1.5:1 moles of hydrogen fluoride per mole of (CF 3 CHClOCHF 2 ) charged to the reaction vessel.
3 . A process as in claim 1 , wherein the temperature of the reaction is in the range of about −10° C. to 30° C.
4 . A process as in claim 1 , wherein the temperature of the reaction is in the range of from about −7° C. to 18° C.
5 . A process as in claim 1 , wherein the mixture is formed by a process comprising:
a) combining said CF 3 CHClOCHF 2 with said antimony pentafluoride; and
b) adding hydrogen fluoride to said combined CF 3 CHClOCHF 2 and antimony pentafluoride while stirring.
6 . A process as in claim 1 , wherein the yield of Desflurane is 60% or greater.
7 . A process as in claim 6 , wherein the reaction conversion is 60% or greater.
8 . A process for the preparation of Desflurane comprising combining CF 3 CHClOCHF 2 , hydrogen fluoride and antimony pentafluoride, wherein the molar amount of hydrogen fluoride added per mole of CF 3 CHClOCHF 2 is in the range of from 0.1:1 to 1.5:1 and the quantity of antimony pentafluoride is preferably in the range of from 0.1 to 10 weight percent relative to the weight of CF 3 CHCIOCHF 2 ; wherein desflurane is formed.
9 . A process as in claim 8 wherein the molar amount of hydrogen fluoride added per mole of CF 3 CHClOCHF 2 is in the range of from 0 of 0.7:1 to 1.1:1 and the quantity of antimony pentafluoride is preferably in the range of from 2 to 2.5 weight % relative to the weight of CF 3 CHClOCHF 2 .
10 . A process as in claim 8 wherein the mixture is formed by a process comprising
a) combining said CF 3 CHClOCHF 2 with said antimony pentafluoride; and
b) adding hydrogen fluoride to said combined CF 3 CHClOCHF 2 and antimony pentafluoride while stirring.
11 . A process as in claim 8 wherein Desflurane is separated out from the reaction mixture.
12 . A process for the preparation of Desflurane comprising:
a) forming a mixture comprising CF 3 CHClOCHF 2 , and antimony pentafluoride; and hydrogen fluoride; and
b) adding hydrogen fluoride to the mixture at a rate approximately equal to or less than the rate at which the hydrogen fluoride reacts with the CF 3 CHClOCHF 2 to form Desflurane.
13 . A process as in claim 12 wherein the temperature of the reaction is in the range of from about −10 to 30° C.
14 . A process as in claim 12 wherein the temperature of the reaction is in the range of from about 15 to 25° C.
15 . A process as in claim 12 wherein the hydrogen fluoride is added at a rate in the range of from about 0.10 to 0.30 moles per hour per mole isoflurane charged to the reaction vessel.
16 . A process as in claim 12 wherein the HF is added at a rate in the range of from about 0.15 to 0.25 moles per hour per mole isoflurane charged to the reaction vessel.
17 . A process as in claim 12 , wherein the yield of Desflurane is 60% or greater.
18 . A process as in claim 12 , wherein the reaction conversion is 60% or greater.
19 . A process as in claim 12 wherein both yield and conversion are above 70%
20 . Desflurane formed by the process of claim 11.