Amide derivative
Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or R1 and R2 may in combination form a ring, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.
1. An amide compound represented by the formula (X):
wherein:
A is any of an aryl group, a heteroaryl group, and a cycloalkyl group;
X is a nitrogen atom or CR17;
Y is —NH— or —NH—CH 2 —;
R8 is an alkyl group optionally having one or more substituents, a halogen atom, a nitro group, or a cyano group; and
R12, R13, R14, R15, R16, and R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, an alkyl group optionally having one or more substituents, an alkenyl group optionally having one or more substituents, or —ZR18, wherein:
Z is —NR19-, —NHC(═O)—, —O—, —C(═O)—, —NH—, —NHS(O) 2 —, —C(═O)O—, or —S—; and
R18 and R19 may be the same or different and each is a hydrogen atom, an alkyl group optionally having one or more substituents, or an aryl group optionally having one or more substituents,
a pharmaceutically acceptable salt thereof, or a hydrate thereof.
2. The amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 , wherein, in formula (X), A is an aryl group or a heteroaryl group.
3. The amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 , wherein, in formula (X),
A is any of a phenyl group, an isoquinolyl group, a pyridyl group, an indazolyl group, a benzothiazolyl group, and a cycloalkyl group;
X is a nitrogen atom or CH;
R8 is a trifluoromethyl group, a chlorine atom, a nitro group, or a cyano group; and
R12, R13, R14, R15, and R16 may be the same or different and each is a hydrogen atom, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a methyl group, an ethyl group, a vinyl group, an isopropyl group, a trifluoromethyl group, a t-butyl group, an n-pentyl group, an n-octyl group, a methoxy group, an amino group, a cyano group, a nitro group, a hydroxyl group, a thiol group, a methoxycarbonyl group, a hydroxymethyl group, a methanesulfonylamino group, an aminoethoxy group, or a benzoyl group.
4. The amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 3 , wherein, in formula (X), A is any of a phenyl group, an isoquinolyl group, a pyridyl group, an indazolyl group, and a benzothiazolyl group.
5. A compound, a pharmaceutically acceptable salt thereof, or hydrate thereof, wherein said compound is selected from the group consisting of:
6. A pharmaceutical composition, comprising an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 , and one or more pharmaceutically acceptable carriers.
7. A method of treating inflammation, comprising administering an effective amount of an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 to a subject in need thereof.
8. A method of treating pain, comprising administering an effective amount of an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof claim 1 to a subject in need thereof.
9. A method of treating inflammatory bowel disease, comprising administering an effective amount of an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 to a subject in need thereof.
10. A method of treating frequent urination or incontinence, comprising administering an effective amount of an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 to a subject in need thereof.
11. A method of treating asthma, comprising administering an effective amount of an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 to a subject in need thereof.
12. A package comprising a pharmaceutical composition, said pharmaceutical composition comprising an amide compound, pharmaceutically acceptable salt thereof, or hydrate thereof of claim 1 and one or more pharmaceutically acceptable carriers, and a written matter wherein said written matter explains use of said pharmaceutical composition.