Nootropic effect enhancer
The invention is to provide an antidementic and/or antiamnesic potency enhancer that comprises an aminopiperazine or aminopiperidine derivative of a formula: (wherein R 1 is a lower alkyl, etc.; R 2 is hydrogen, etc.; R 3 is an aryl, etc.; A is —CO—, etc.; X is N or CH; Y is —CO—, etc.), for attaining higher antidementic and/or antiamnesic potency.
1 - 3 . (canceled)
4 . A composition comprising:
donepedil or a pharmaceutically acceptable salt thereof, and
an aminopiperazine or aminopiperidine compound having the following formula:
wherein R 1 represents a lower alkyl; R 2 represents hydrogen; R 3 represents phenyl that may be substituted with a halogen; A represents —CO—; X represents N or CH; and Y represents —CO—.
5 . The composition of claim 4 , wherein said antidementic or antiamnesic drug comprises donepedil hydrochloride.
6 . The composition of claim 4 , comprising a compound of formula (I) where R 1 is methyl.
7 . The composition of claim 4 , comprising a compound of formula (I) where R 3 is unsubstituted phenyl.
8 . The composition of claim 4 , comprising a compound of formula (I) where R 3 is halogen-substituted phenyl.
9 . The composition of claim 4 , comprising a compound of formula (I) where R 3 is fluorine-substituted phenyl.
10 . The composition of claim 4 , comprising a compound of formula (I) where X is N.
11 . The composition of claim 4 , comprising a compound of formula (I) where X is CH.
12 . The composition of claim 4 , comprising a compound of formula (I) where R 1 is methyl, R 3 is p-fluorine-substituted phenyl, and X is CH—.
13 . The composition of claim 4 , comprising a compound of formula (I) where R 1 is methyl, R 3 is p-fluorine-substituted phenyl, and X is N.
14 . The composition of claim 4 , comprising donepedil hydrochloride.
15 . The composition of claim 4 , which comprises donepedil hydrochloride and FK960.
16 . A method for treating dementia or amnesia comprising administering to a subject in need thereof:
donepedil or a pharmaceutically acceptable salt thereof, and
an aminopiperazine or aminopiperidine compound having the following formula:
wherein R 1 represents a lower alkyl, R 2 represents hydrogen; R 3 represents phenyl that may be substituted with a halogen; A represents —CO—; X represents N or CH; Y represents —CO—.
17 . The method of claim 16 , wherein the dosage of the compound of formula (I) ranges from 0.1 to 200 mg/adult.
18 . The method of claim 16 , wherein the ratio of the donepedil or a pharmaceutically acceptable salt thereof to the compound of formula (I) ranges from 1:100 to 100:1.
19 . The method of claim 16 , wherein the ratio of the donepedil or a pharmaceutically acceptable salt thereof to the compound of formula (I) ranges from 1:10 to 10:1.
20 . The method of claim 16 , which comprises administering to said subject donepedil hydrochloride.
21 . The method of claim 20 , wherein the ratio of donepedil hydrochloride to the compound of formula (I) ranges from 1:10 to 10:1.
22 . The method of claim 20 , comprising administering to a subject in need thereof an effective amount of donepedil hydrochloride and FK960.