Compounds for the treatment of inflammatory disorders
View Patent ↗This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-α or combinations thereof.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt, solution-phase solvate or ester thereof.
2. The compound of claim 1 , wherein said compound is selected from the group consisting of
or a pharmaceutically acceptable salt, solution-phase solvate or ester thereof.
3. A pharmaceutical composition comprising as an active ingredient at least one compound of claim 1 or a pharmaceutically acceptable salt, solution-phase solvate or ester thereof.
4. The pharmaceutical composition of claim 3 , additionally comprising at least one pharmaceutically acceptable carrier.
5. A compound of claim 1 or a pharmaceutically acceptable salt, solution-phase solvate or ester thereof in purified form.