Attenuated vaccine useful for immunizations against
View Patent ↗A Coccidioides spp. fungus that is attenuated by the loss of endosporulation potential of the fungus wherein said fungus does not replicate when transformed into the parasitic phase.
1. A Coccidioides posadasii fungus comprising a polynucleotide with the sequence of SEQ ID NO:13 and a polynucleotide with the sequence of SEQ ID NO:14.
2. A composition comprising the fungus of claim 1 in combination with a pharmaceutically acceptable carrier.
3. A live, attenuated Coccidioides posadasii vaccine comprising the fungus of claim 1 .
4. A method of eliciting an immune response in a mammal comprising the step of administering to the mammal a composition comprising the fungus of claim 1 in an amount sufficient to elicit an immune response.
5. The method of claim 4 , wherein said mammal is a human.
6. The method of claim 4 , wherein said mammal is a domestic animal selected from the group consisting of dog, cat, horse, and bovine.
7. The method of claim 4 , wherein the recombinant fungus is administered to the mammal by subcutaneous injection or by intramuscular injection.