Topical nepafenac formulations
View Patent ↗Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.
1. A method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient a composition consisting of
a) 0.1% (w/v) nepafenac;
b) 0.5% (w/v) carbomer;
c) 0.01% (w/v) tyloxapol;
d) 0.4% (w/v) sodium chloride;
e) 2.4% (w/v) mannitol;
f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7;
g) 0.005% (w/v) benzalkonium chloride;
h) 0.01% edetate disodium; and
i) purified water.
2. In a method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient an aqueous suspension composition comprising nepafenac, the improvement wherein the composition consists of
a) 0.1% (w/v) nepafenac;
b) 0.5% (w/v) carbomer;
c) 0.01% (w/v) tyloxapol;
d) 0.4% (w/v) sodium chloride;
e) 2.4% (w/v) mannitol;
f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7;
g) 0.005% (w/v) benzalkonium chloride;
h) 0.01% edetate disodium; and
i) purified water.