IP Library Granted Patent US 7,834,059
Granted Patent B2
US 7,834,059 · App. 11/292,484 · Granted Nov 16, 2010

Topical nepafenac formulations

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Quick Facts
Patent No.
US 7,834,059
App. No.
11/292,484
Granted
Nov 16, 2010
Kind
B2
Abstract

Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.

Claims (20)

1. A method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient a composition consisting of

a) 0.1% (w/v) nepafenac;

b) 0.5% (w/v) carbomer;

c) 0.01% (w/v) tyloxapol;

d) 0.4% (w/v) sodium chloride;

e) 2.4% (w/v) mannitol;

f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7;

g) 0.005% (w/v) benzalkonium chloride;

h) 0.01% edetate disodium; and

i) purified water.

2. In a method of treating ophthalmic inflammatory disorders in a human patient comprising topically administering to the patient an aqueous suspension composition comprising nepafenac, the improvement wherein the composition consists of

a) 0.1% (w/v) nepafenac;

b) 0.5% (w/v) carbomer;

c) 0.01% (w/v) tyloxapol;

d) 0.4% (w/v) sodium chloride;

e) 2.4% (w/v) mannitol;

f) a pH-adjusting agent in an amount sufficient to cause the composition to have a pH of 7.3-7.7;

g) 0.005% (w/v) benzalkonium chloride;

h) 0.01% edetate disodium; and

i) purified water.

Assignments (8)
SECURITY INTEREST Recorded Sep 26, 2025
From: HARROW, INC.; HARROW IP, LLC
To: FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 072384/0781 →
RELEASE OF SECURITY INTEREST Recorded Sep 18, 2025
From: OAKTREE FUND ADMINISTRATION, LLC, AS ADMINISTRATIVE AGENT
To: HARROW IP, LLC
Reel/Frame 072299/0911 →
PATENT SECURITY AGREEMENT Recorded Mar 30, 2023
From: HARROW IP, LLC
To: OAKTREE FUND ADMINISTRATION, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 063205/0708 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 62452/0106 Recorded Mar 30, 2023
From: B. RILEY COMMERCIAL CAPITAL, LLC, AS ADMINISTRATIVE AGENT
To: HARROW HEALTH, INC.; HARROW EYE, LLC; HARROW IP, LLC; IMPRIMISRX, LLC; IMPRIMIS NJOF, LLC; IMPRIMISRX NJ, LLC; VISIONOLOGY EQUITY, LLC; VISIONOLOGY, INC.; VISIONOLOGY MSO, INC.
Reel/Frame 063206/0156 →
SECURITY INTEREST Recorded Jan 23, 2023
From: HARROW HEALTH, INC.; HARROW IP, LLC; IMPRIMISRX, LLC; HARROW EYE, LLC; IMPRIMIS NJOF, LLC; IMPRIMISRX NJ, LLC; VISIONOLOGY EQUITY, LLC; VISIONOLOGY, INC.; VISIONOLOGY MSO, INC.
To: B. RILEY COMMERCIAL CAPITAL, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 062452/0106 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2023
From: NOVARTIS AG
To: HARROW IP, LLC
Reel/Frame 062442/0255 →
MERGER Recorded May 31, 2011
From: ALCON, INC.
To: NOVARTIS AG
Reel/Frame 026376/0076 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 2, 2005
From: WONG, WARREN
To: ALCON, INC.
Reel/Frame 017285/0095 →