IP Library Granted Patent US 7,979,134
Granted Patent B2
US 7,979,134 · App. 11/293,871 · Granted Jul 12, 2011

Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment

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Quick Facts
Patent No.
US 7,979,134
App. No.
11/293,871
Granted
Jul 12, 2011
Kind
B2
Abstract

An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space.

Claims (56)

1. An artificial retina device comprising:

an electrical source;

a stimulating electrode unit configured to be located adjacent to a neuroretina in an eye of a patient and having at least one stimulating electrode which receives current from the electrical source for electrical stimulation of neuroretinal cells; and

a ground return electrode connected with the at least one stimulating electrode;

an elongate extension that extends away from the stimulating electrode unit;

wherein the ground return electrode is provided on the elongate extension spaced from the stimulating electrode unit, such that the ground return electrode is configured to be located at an extended location spaced from the neuroretina and is configured to be separated from the stimulating electrode unit by a layer of tissue and/or by vitreous fluid.

2. The device of claim 1 , wherein the stimulating electrode unit is configured to be positioned epiretinally.

3. The device of claim 1 , wherein the stimulating electrode unit is configured to be positioned subretinally.

4. The device of claim 1 , wherein the stimulating electrode and ground electrode are configured to direct an electrical field through the neuroretina.

5. The device of claim 4 , wherein the stimulating electrode and the ground electrode are configured to direct the electrical field substantially perpendicular to the neuroretina.

6. The device of claim 1 , wherein the stimulating electrode and the ground return electrode are configured to be disposed on opposite sides of the neuroretina.

7. The device of claim 1 , wherein a distance between the stimulating electrode and the ground return electrode at the extended location is less than or equal to a diameter of the eye.

8. The device of claim 1 , wherein a distance between the stimulating electrode and the ground return electrode at the extended location is less than or equal to a diameter of a vitreous cavity of the eye.

9. The device of claim 1 , wherein the elongate extension comprises an insulated electrical conductor.

10. The device of claim 9 , wherein the insulating electrical conductor is configured to extend through the layer of tissue.

11. The device of claim 9 , wherein the insulated electrical conductor comprises a cable.

12. The device of claim 1 , further comprising a coil which forms part of the electrical source, wherein the coil is in communication with the at least one stimulating electrode and the ground return electrode.

13. The device of claim 12 , wherein the electrical source transmits a wireless signal to the at least one stimulating electrode via the coil.

14. The device of claim 1 , wherein the ground return electrode is configured to be positioned outside of a vitreous cavity of the eye.

15. The device of claim 1 , wherein the ground return electrode is configured to be positioned outside of the eye.

16. The device of claim 1 , wherein the ground return electrode is configured to be positioned outside of a sclera of the eye.

17. The device of claim 1 , wherein the ground return electrode is configured to be positioned on a sclera surface on an outside of the eye.

18. A method of using an artificial retina device, wherein the artificial retina device comprises an electrical source, a stimulating electrode unit having at least one stimulating electrode for electrical stimulation of neuroretinal cells in an eye of a patient, and a ground return electrode connected with the stimulating electrode unit via an elongate extension, the method comprising:

positioning the stimulating electrode unit adjacent to a neuroretina; and

positioning the ground return electrode at an extended location which is spaced from the neuroretina and separated from the stimulating electrode unit by at least one layer of tissue and/or by vitreous fluid.

19. The method of claim 18 , wherein the ground return electrode is positioned in a vitreous cavity of the eye.

20. The method of claim 18 , wherein the ground return electrode is positioned outside of a vitreous cavity of the eye.

21. The method of claim 18 , wherein the ground return electrode is positioned outside of the eye.

22. The method of claim 18 , wherein the ground return electrode is positioned outside of a sclera of the eye.

23. The method of claim 18 , wherein the ground return electrode is positioned on a sclera surface outside of the eye.

24. An artificial retina device for electrically stimulating a neuroretina in an eye of a patient to produce artificial vision, the artificial retina device comprising:

an electrical source;

a stimulating electrode unit configured to be located adjacent a first side of the neuroretina and having at least one stimulating electrode configured to receive current from the electrical source for electrical stimulation of the neuroretina;

an elongate extension; and

a ground return electrode connected with the at least one stimulating electrode via the elongate extension from the stimulating electrode unit, wherein the ground return electrode is configured to be located at an extended location spaced from a second side of the neuroretina and wherein the ground electrode is configured to be separated from the stimulating electrode unit by a layer of tissue and/or by vitreous fluid.

25. The device of claim 24 , wherein the stimulating electrode unit is configured to be positioned epiretinally.

26. The device of claim 24 , wherein the stimulating electrode and ground electrode are configured to direct an electrical field through the neuroretina.

27. The device of claim 24 , wherein the elongate extension comprises an insulated electrical conductor configured to extend through the layer of tissue.

28. The device of claim 24 , further comprising a coil which forms part of the electrical source, wherein the coil is in communication with the at least one stimulating electrode and the ground return electrode.

29. The device of claim 28 , wherein the electrical source transmits a wireless signal to the at least one stimulating electrode via the coil.

30. The device of claim 24 , wherein the ground return electrode is configured to be positioned outside of a vitreous cavity of the eye or outside of a sclera of the eye.

31. The device of claim 24 , wherein the at least one stimulating electrode includes multiple stimulating electrodes.

32. An artificial retina device for electrically stimulating a neuroretina in an eye of a patient to produce artificial vision, the artificial retina device comprising:

an electrical source;

a stimulating electrode unit configured to be located adjacent the neuroretina and having at least one stimulating electrode configured to receive a signal from the electrical source for electrical stimulation of the neuroretina;

an elongate extension connected to and extending out from the stimulating electrode unit; and

a ground return electrode provided on the elongate extension at a position remote from the stimulating electrode unit and connected with the at least one stimulating electrode via the elongate extension.

33. The device of claim 32 , wherein the stimulating electrode unit is configured to be positioned epiretinally.

34. The device of claim 32 , wherein the stimulating electrode and ground electrode are configured to direct an electrical field through the neuroretina.

35. The device of claim 32 , wherein a distance between the stimulating electrode and the ground return electrode at the extended location is less than or equal to a diameter of the eye.

36. The device of claim 32 , wherein the elongate extension comprises an insulated electrical conductor configured to extend through the layer of tissue.

37. The device of claim 36 , wherein the insulated electrical conductor comprises a cable.

38. The device of claim 32 , further comprising a coil which forms part of the electrical source, wherein the coil is in communication with the at least one stimulating electrode and the ground return electrode.

39. The device of claim 38 , wherein the electrical source transmits a wireless signal to the at least one stimulating electrode via the coil.

40. The device of claim 32 , wherein the ground return electrode is configured to be positioned outside of a vitreous cavity of the eye or outside of the eye.

41. The device of claim 32 , wherein the at least one stimulating electrode includes multiple stimulating electrodes.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 25, 2013
From: IMI INTELLIGENT MEDICAL IMPLANTS AG
To: PIXIUM VISION SA
Reel/Frame 031719/0914 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 15, 2008
From: OPTOBIONICS CORPORATION
To: IMI INTELLIGENT MEDICAL IMPLANTS AG
Reel/Frame 020507/0679 →
SECURITY AGREEMENT Recorded Apr 23, 2007
From: OPTOBIONICS CORPORATION
To: ARCH VENTURE FUND III, L.P.; ARCH VENTURE FUND V, L.P.; ARCH V ENTREPRENEURS FUND, L.P.; POLARIS VENTURE PARTNERS, L.P.; POLARIS VENTURE PARTNERS FOUNDERS' FUND, L.P.; POLARIS VENTURE PARTNERS III, L.P.; POLARIS VENTURE PARTNERS ENTREPRENEURS' FUND III, L.P.; POLARIS VENTURE PARTNERS FOUNDERS' FUND III, L.P.; ADVANCED TECHNOLOGY VENTURES V, L.P.; ATV ENTREPRENEURS V, L.P.; MEDTRONIC INTERNATIONAL, LTD.; CHO, ALAN
Reel/Frame 019181/0882 →