Method for treating neuropathic pain and associated syndromes

1. A method of treating a mammalian subject suffering from existing neuropathic pain, said method comprising:

selecting a mammalian subject experiencing existing neuropathic pain, wherein said subject does not have multiple sclerosis; and

administering to said subject an initial therapeutic dosage of 60-100 mg/day of ibudilast, whereby as a result of said administering, the subject experiences relief of said neuropathic pain, wherein no ibudilast is administered prior to the onset of neuropathic pain symptoms.

2. The method of claim 1 , wherein said selecting step comprises selecting a mammalian subject suffering from postherpatic neuralgia, trigeminal neuralgia, and neuropathic pain associated with a condition selected from the group consisting of herpes, HIV, traumatic nerve injury, stroke, post-ischemia, fibromyalgia, reflex sympathetic dystrophy, complex regional pain syndrome, spinal cord injury, sciatica, phantom limb pain, diabetic neuropathy, and cancer chemotherapeutic-induced neuropathic pain.

3. The method of claim 1 , wherein said administering step comprises systemically administering ibudilast.

4. The method of claim 3 , wherein said ibudilast is administered by a route selected from oral, intravenous, subcutaneous, intramuscular, intraperitoneal, intranasal, and sublingual.

5. The method of claim 1 , wherein said administering step comprises centrally administering ibudilast by a route selected from intrathecal, intraspinal and intranasal.

6. The method of claim 1 , wherein said administering comprises once daily dosing.

7. The method of claim 1 , wherein said administering comprises twice or thrice daily dosing.

8. The method of claim 1 , wherein said administering is over a time course of at least about a week.

9. The method of claim 1 , wherein said administering is over a time course ranging from about one week to 50 weeks.

10. The method of claim 1 , wherein said administering step is not accompanied by administration of an anti-emetic.

11. The method of claim 1 , whereby said subject is experiencing allodynia, and said administering is effective to relieve allodynia experienced by said subject.

12. The method of claim 1 , wherein said administering is effective to attenuate neuropathic pain experienced by said subject for up to at least 16 hours post ibudilast administration.

13. The method of claim 1 , wherein said administering step comprises administering ibudilast in combination with an additional agent effective for treating neuropathic pain.

14. The method of claim 13 , wherein said additional agent possesses a mechanism of action different from ibudilast.

15. The method of claim 14 , wherein said additional agent is selected from the group consisting of gabapentin, memantine, pregabalin, morphine and related opiates, cannabinoids, tramadol, lamotrigine, lidocaine, carbamazepine, duloxetine, milnacipran, and tricyclic antidepressants.