The present invention relates to the use of GABA B receptor agonists for the treatment as well as the prevention of cough.
1. A method for inhibiting or treating cough, comprising administering to a subject in need thereof a pharmaceutically and pharmacologically effective amount of a compound of formula (I)
as well as a pharmaceutically acceptable salt, a solvate or an optical isomer thereof, wherein
R 1 represents a hydroxy group, a halogen or an oxo group.
2. The method according to claim 1 , wherein said halogen is fluorine.
3. The method according to claim 1 , wherein the cough is chronic cough.
4. A method for inhibiting or treating cough, comprising administering to a subject in need thereof a pharmaceutically and pharmacologically effective amount of a compound of formula (II)
as well as a pharmaceutically acceptable salt, a solvate or an optical isomer thereof, wherein
R 2 represents hydrogen, a hydroxy group, C 1 -C 7 alkyl, C 1 -C 7 alkoxy or halogen;
R 3 represents hydrogen, C 1 -C 7 alkyl (optionally substituted with hydroxy, mercapto, C 1 -C 7 alkoxy, C 1 -C 7 thioalkoxy, aryl or heteroaryl), aryl or heteroaryl;
with the proviso that R 2 and R 3 are not hydrogen at the same time.
5. The method according to claim 4 , wherein the cough is chronic cough.
6. A method for inhibiting or treating cough, comprising administering to a subject in need thereof a pharmaceutically and pharmacologically effective amount of a compound of formula (III)
as well as a pharmaceutically acceptable salt, a solvate or an optical isomer thereof, wherein
R 4 represents hydrogen, hydroxy group or halogen;
R 5 represents hydrogen, hydroxy group, mercapto, halogen, or an oxo group;
R 6 represents hydrogen or C 1 -C 7 alkyl (optionally substituted with hydroxy, mercapto, C 1 -C 7 alkoxy, C 1 -C 7 thioalkoxy, aryl or heteroaryl), aryl or heteroaryl.
7. The method according to claim 6 , wherein the cough is chronic chough.