Treatment of pain with 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone or salt thereof
Therapeutic methods are provided for treating pain and fibromyalgia by administration of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone or a prodrug or salt thereof.
1 . A method of treating pain in an individual in need of such treatment, comprising administering to the individual an effective amount of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone, a prodrug thereof, or a pharmaceutically acceptable salt thereof.
2 . The method according to claim 2 , wherein the pharmaceutically acceptable salt is 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone monomethanesulfonate.
3 . The method of claim 1 , wherein said pain is nociceptive pain.
4 . The method of claim 1 , wherein said pain is pain associated with fibromyalgia.
5 . The method of claim 1 , wherein said pain is neuropathic pain.
6 . The method of claim 5 , wherein said pain is associated with a metabolic insult other than diabetes.
7 . The method of claim 6 wherein said pain is associated with a systemic disorder.
8 . The method of claim 5 wherein said pain is associated with a physical or chemical injury.
9 . The method of claim 8 wherein said pain is associated with an injury comprising nerve root compression.
10 . A method of treating fibromyalgia in an individual in need of such treatment, comprising administering to the individual an effective amount of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone, a prodrug thereof, or a pharmaceutically acceptable salt thereof.
11 . The method according to claim 10 , wherein the pharmaceutically acceptable salt is 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone monomethanesulfonate.